ERK Inhibitor

Product Name: ERK Inhibitor
CAS No.: 1049738-54-6
Chemical Name: ERK Inhibitor
Synonyms: ERK-IN-4;ERK Inhibitor - CAS 1049738-54-6 - Calbiochem;3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione,monohydrochloride;(5Z)-3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione:hydrochloride
CBNumber: CB13136749
Molecular Formula: C14H17ClN2O3S
Formula Weight: 328.81
MOL File: 1049738-54-6.mol

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ERK Inhibitor Property

storage temp.: +2C to +8C
solubility: DMSO: 2 mg/ml
form: Light yellow solid
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15944
Product name: ERK Inhibitor
Purity: ≥95%
Packaging: 500μg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 15944
Product name: ERK Inhibitor
Purity: ≥95%
Packaging: 1mg
Price: $50
Updated: 2024/03/01

Cayman Chemical

Product number: 15944
Product name: ERK Inhibitor
Purity: ≥95%
Packaging: 5mg
Price: $117
Updated: 2024/03/01

AK Scientific

Product number: 9473CW
Product name: ErkInhibitor
Packaging: 5mg
Price: $228
Updated: 2021/12/16

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ERK Inhibitor Chemical Properties,Usage,Production

Description

ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (K_D = 5 μM). This prevents its interaction with protein substrates without inhibiting catalytic activity. ERK inhibitor blocks ERK-specific phosphorylation of ribosomal S6 kinase-1 and ternary complex factor Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2. Presumably through its effects on ERK, ERK inhibitor completely prevents proliferation of HeLa cells (IC₅₀ = 15-20 μM), A549 lung carcinoma cells (IC₅₀ = 25 μM), Sum-159 estrogen receptor-negative breast cancer cells and HT1080 fibrosarcoma cells.

General Description

A cell-permeable and reversible thiazolidinedione compound that displays anti-proliferative properties (IC₅₀ ≤ 25 μM in HeLa, A549, and SUM-159 tumor cells). Preferentially binds to ERK2 with a K_D of ~5 μM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting little effect on ERK1/2 phosphorylation by MEK1/2.

Biochem/physiol Actions

Primary TargetERK

ERK Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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ERK Inhibitor Suppliers

China 23 United States 5 Global 28

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

1049738-54-6, ERK InhibitorRelated Search:

N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE 2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone Chk2 Inhibitor Trolox NSC 23766 TETRAHYDROCHLORIDE NSC697923 MIF Antagonist, ISO-1 GSK-3β Inhibitor XVIII Pictilisib JNJ-10198409 Motesanib C2 CERAMIDE PD 173074 Compound 28 Glycogen Phosphorylase Inhibitor Compound 23 MMP-9 INHIBITOR I 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID

(5Z)-3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione:hydrochloride

ERK Inhibitor - CAS 1049738-54-6 - Calbiochem

3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione,monohydrochloride

ERK-IN-4

1049738-54-6