SR 0987
- Product Name
- SR 0987
- CAS No.
- 303126-97-8
- Chemical Name
- SR 0987
- Synonyms
- SR 0987;SR0987 >=98% (HPLC);SR 0987;SR-0987;SR0987;303126-97-8;SR0987,ROR,SR-0987,Inhibitor,SR 0987,inhibit,RAR-related orphan receptor;2-chloro-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide;2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide;Benzamide, 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-
- CBNumber
- CB13152747
- Molecular Formula
- C16H10ClF6NO2
- Formula Weight
- 397.7
- MOL File
- 303126-97-8.mol
SR 0987 Property
- Boiling point:
- 378.8±42.0 °C(Predicted)
- Density
- 1.525±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Soluble in DMSO (up to at least 25 mg/ml) and Ethanol (up to at least 25 mg/ml)
- pka
- 9.22±0.15(Predicted)
- form
- solid
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 19503
- Product name
- SR 0987
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $27
- Updated
- 2024/03/01
- Product number
- 19503
- Product name
- SR 0987
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 19503
- Product name
- SR 0987
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $122
- Updated
- 2024/03/01
- Product number
- 19503
- Product name
- SR 0987
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $236
- Updated
- 2024/03/01
- Product number
- 5868
- Product name
- SR0987
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $704
- Updated
- 2021/12/16
SR 0987 Chemical Properties,Usage,Production
Description
SR 0987 is an agonist of the T cell-specific isoform of RORγ (RORγt, retinoic acid receptor-related orphan receptor-γt), inducing reporter gene expression with an EC50 value of ~800 nM. Stimulation of mouse EL4 T lymphocytes with SR 0987, following activation with PMA and ionomycin , increases expression of the RORγt target IL-17, while expression of the programmed cell death protein PD-1 is decreased and granzyme B is unchanged. Decreased cell surface PD-1 protein, assessed by flow cytometry, is observed in a variety of T cells treated with SR 0987.
Uses
SR 0987 is a RORγt agonist.
storage
Store at +4°C
References
1) Chang?et al.?(2016),?Synthetic RORγt Agonists Enhance Protective Immunity;?ACS Chem. Biol.?11?1012
SR 0987 Preparation Products And Raw materials
Raw materials
Preparation Products
SR 0987 Suppliers
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6393
- Advantage
- 58
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57511
- Advantage
- 58
- Tel
- +1-781-999-5354
- support@targetmol.com
- Country
- United States
- ProdList
- 19973
- Advantage
- 58