Fleroxacin

Product Name: Fleroxacin
CAS No.: 79660-72-3
Chemical Name: Fleroxacin
Synonyms: AM-833;QUINODIS;MEGALONE;MEGALOCIN;RO-23-6240;FLEROXACIN;ro23-6240/000;Fleroxacin>Erlotinib-d12 HCl;Fleroxacin, >=99%
CBNumber: CB1331989
Molecular Formula: C17H18F3N3O3
Formula Weight: 369.34
MOL File: 79660-72-3.mol

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Fleroxacin Property

Melting point:: 264-266°C
Boiling point:: 535.3±50.0 °C(Predicted)
Density: 1.409±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: 0.1 M NaOH: soluble10mg/mL
form: solid
pka: -0.54±0.20(Predicted)
color: white to off-white
Merck: 14,4099
CAS DataBase Reference: 79660-72-3(CAS DataBase Reference)

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Safety

WGK Germany: 2
RTECS: VB1999050
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H371May cause damage to organs

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: F6807
Product name: Fleroxacin
Purity: ≥98% (HPLC)
Packaging: 1g
Price: $631
Updated: 2023/06/20

Sigma-Aldrich

Product number: 33930
Product name: Fleroxacin
Purity: VETRANAL?, analytical standard
Packaging: 100MG
Price: $122
Updated: 2022/05/15

TCI Chemical

Product number: F0646
Product name: Fleroxacin
Purity: >98.0%(T)
Packaging: 5g
Price: $147
Updated: 2024/03/01

TCI Chemical

Product number: F0646
Product name: Fleroxacin
Purity: >98.0%(T)
Packaging: 25g
Price: $574
Updated: 2024/03/01

Cayman Chemical

Product number: 24173
Product name: Fleroxacin
Purity: ≥98%
Packaging: 1g
Price: $57
Updated: 2024/03/01

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Fleroxacin Chemical Properties,Usage,Production

Description

Fleroxacin is a new, once daily trifluoroquinolone antibacterial structurally related to norfloxacin. Available in both oral and IV formulations, it is reportedly useful in the treatment of gonorrhea, bacterial enteritis, chronic bronchitis and urinary tract infections. Fleroxacin has a longer serum half-life (9-12 hours) than other drugs of this class, such as ciprofloxacin, enoxacin and norfloxacin.

Chemical Properties

White Needle-Like Crystals

Originator

Kyorin (Japan)

Uses

An antibacterial.

Uses

antibiotic

Definition

ChEBI: A fluoroquinolone antibiotic that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6, 7 and 8 by 2-fluoroethyl, carboxy, fluoro, 4-methylpiperazin-1-yl and fluoro groups, respectively. It is active against many Gram-positive and Gram-n gative bacteria.

Manufacturing Process

6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4- oxoquinoline-3-carboxylic acid hydrochloride:
A mixed solution of 1-methylpiperazine (0.34 g) and pyridine (3 ml) was added to 6,7,8-trifluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxoquinoline-3- carboxylic acid (0.12 g) and heated to reflux for 6 hours. After the solvent evaporated and cooled, the residue was adjusted to pH 1 with aqueous hydrochloric acid. The cooled mixture was filtered off and the solid recrystallized from water to give 6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7- (4-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride (0.08 g), melting point 269-271°C (decomp.).

brand name

Quinodis

Therapeutic Function

Antibacterial

Fleroxacin Preparation Products And Raw materials

Raw materials

Fluorobromoethane 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester QUINOLINE-3-CARBOXYLIC ACID Ethanol 2,3,4-Trifluorobenzenamine Acetic anhydride Diethyl ethoxymethylenemalonate Potassium carbonate

Preparation Products

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Fleroxacin Suppliers

Americas 1 Canada 1 China 241 Europe 3 Germany 2 India 3 Japan 1 Switzerland 1 United Kingdom 9 United States 27 Global 289

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View Lastest Price from Fleroxacin manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Fleroxacin 79660-72-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-18

Hebei Chuanghai Biotechnology Co,.LTD

Product: Fleroxacin 79660-72-3
Price: US $1.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 ton
Release date: 2024-08-20

Henan Fengda Chemical Co., Ltd

Product: Fleroxacin 79660-72-3
Price: US $36.00-1.20/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-16

79660-72-3, FleroxacinRelated Search:

(2-Methoxyethyl)benzene 1-Methylpiperazine DL-α-Tocopherol N-Aminoethylpiperazine Diphenolic acid 4-(Diethylamino)salicylaldehyde 5-Chlorovaleric acid Pralmorelin Methyl 2-hydroxyethyl cellulose Dihydromyrcenol 2-Butanone 4-AMINO-3,5-DIFLUOROACETOPHENONE 3-(4-Methylpiperazin-1-yl)aniline Pefloxacin FLEROXACINLACTATE Norfloxacin 8-FLUORO-4(1H)-QUINOLINONE Benzenamine, 3-(1-piperazinyl)- (9CI)

Erlotinib-d12 HCl

6,8-difluoro-1-(2-fluoroethyl)-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid

AM-833, Ro-23-6240, Megalocin, Megalone, Quinodis, 6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid

AM-833, Megalocin, Megalone, 6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methylpiperazino)-4-oxo-3-quinolinecarboxylic acid, 6,8-Difluoro-1-(2-fluoroethyl)1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid

6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-7-(4-methyl-1-piperazinyl)quinoline-3-carboxylic acid

6,8-difluoro-1-(2-fluoroethyl)-4-keto-7-(4-methylpiperazin-1-yl)quinoline-3-carboxylic acid

6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic acid

6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid

6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylicacid

6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid Megalone

Fleroxacin Solution, 100ppm

RO-23-6240

QUINODIS

3-quinolinecarboxylicacid,1,4-dihydro-6,8-difluoro-1-(2-fluoroethyl)-7-(4-met

hyl-1-piperazinyl)-4-oxo-

ro23-6240/000

Fleroxacin solution,1000ppm

Fleroxacin, >=99%

FLEROXACIN

MEGALOCIN

MEGALONE

AM-833

6,8-DIFLUORO-1-(2-FLUOROETHYL)-1,4-DIHYDRO-7-(4-METHYL-1-PIPERAZINYL)-4-OXO-3-QUINOLINECARBOXYLIC ACID

6,8-DIFLUORO-1-(2-FLUOROETHYL)-1,4-DIHYDRO-7-(4-METHYLPIPERAZINO)-4-OXO-3-QUINOLINECARBOXYLIC ACID

Fleroxacin&gt

Fleroxacin Fleroxacin

Fleroxacin, 98%, for analysis

3-Quinolinecarboxylic acid, 6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-

Fleroxacin USP/EP/BP

6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-4-ium-1-yl)-4-oxoquinoline-3-carboxylate

6,8-Difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Fluorine Rosa star

6,8-Difluoro-1-(2-fluoroethyl)-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid

C13658000 Fleroxacin

Fleroxacin in Methanol

79660-72-3

79960-72-3

79660-72-7

C17H18F3NC3H6O3

C17H18F3N3O3

Quinodis, Megalocin

Antibiotics for Research and Experimental Use

Biochemistry

Quinolones (Antibiotics for Research and Experimental Use)

Intermediates & Fine Chemicals

Pharmaceuticals