ChemicalBook > CAS DataBase List > 3-Fluoro-2-hydroxybenzaldehyde

3-Fluoro-2-hydroxybenzaldehyde

Product Name: 3-Fluoro-2-hydroxybenzaldehyde
CAS No.: 394-50-3
Chemical Name: 3-Fluoro-2-hydroxybenzaldehyde
Synonyms: 3-FLUOROSALICYLALDEHYDE;3-Fluoro-2-hydroxybe;3-fluorosalicyldadehyde;1-Fluoro-6-formylphenol;3-Fluorosalicylaldehyde>3-Fluorosalicylaldehyde,98%;3-Fluorosalicylaldehyde ,99%;5-Fluoro-3-nitroacetophenone;3-FLUORO-2-HYDROXYBENZALDEHYDE;2-Hydroxy-3-fluorobenzaldehyde
CBNumber: CB1367319
Molecular Formula: C7H5FO2
Formula Weight: 140.11
MOL File: 394-50-3.mol

Less

3-Fluoro-2-hydroxybenzaldehyde Property

Melting point:: 68-70 °C(lit.)
Boiling point:: 176.2±20.0 °C(Predicted)
Density: 1.350±0.06 g/cm3(Predicted)
storage temp.: 2-8°C, stored under nitrogen
Water Solubility: Insoluble in water
pka: 6.91±0.10(Predicted)
form: Crystalline Powder
color: White to light yellow
Sensitive: Air Sensitive
BRN: 1932806
InChI: InChI=1S/C7H5FO2/c8-6-3-1-2-5(4-9)7(6)10/h1-4,10H
InChIKey: NWDHTEIVMDYWQJ-UHFFFAOYSA-N
SMILES: C(=O)C1=CC=CC(F)=C1O
CAS DataBase Reference: 394-50-3(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29124990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 319805
Product name: 3-Fluorosalicylaldehyde
Purity: 97%
Packaging: 1g
Price: $94.7
Updated: 2022/05/15

Sigma-Aldrich

Product number: 319805
Product name: 3-Fluorosalicylaldehyde
Purity: 97%
Packaging: 250mg
Price: $95.5
Updated: 2022/05/15

TCI Chemical

Product number: F0625
Product name: 3-Fluorosalicylaldehyde
Purity: >98.0%(GC)
Packaging: 1g
Price: $70
Updated: 2025/07/31

TCI Chemical

Product number: F0625
Product name: 3-Fluorosalicylaldehyde
Purity: >98.0%(GC)
Packaging: 5g
Price: $204
Updated: 2025/07/31

TRC

Product number: F598025
Product name: 3-Fluoro-2-hydroxybenzaldehyde
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Less

3-Fluoro-2-hydroxybenzaldehyde Chemical Properties,Usage,Production

Chemical Properties

White to light yellow crystalline powder

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 2502, 1946 DOI: 10.1021/ja01216a020

Synthesis

109-72-8

98015-07-7

394-50-3

A hexane solution of n-butyllithium (17.07 mL, 1.42 M, 25.1 mmol) was slowly added dropwise to a stirred solution of 2-(2-bromo-5-methoxyphenyl)-1,3-dioxolane (5.00 g, 19.3 mmol) dissolved in dry tetrahydrofuran (60 mL) at -78°C. The reaction mixture was stirred continuously at -78 °C for 30 min before being quenched by the addition of iodomethane (2.40 mL, 38.6 mmol). After quenching, the solution was continued stirring at -78 °C for 20 min, followed by termination of the reaction with saturated aqueous ammonium chloride solution (60 mL). The organic phase was separated, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast column chromatography using hexane:ethyl acetate (10:1) as eluent to afford the light yellow oily target product 3-fluoro-2-hydroxybenzaldehyde (3.07 g, 82% yield). Thin layer chromatography showed an Rf value of 0.40 (Expanding agent: hexane:ethyl acetate, 10:1). The NMR hydrogen spectrum (300 MHz, CDCl3) data were as follows: δ 7.20-6.99 (2H, m, Ar-H), 6.75 (1H, dd, Ar-H), 5.92 (1H, s, CH), 4.20-4.01 (4H, m, 2 × CH2), 3.80 (3H, s, OCH3), 2.32 (3H, s, CH3) .

References

[1] Patent: WO2004/43903, 2004, A1. Location in patent: Page 31

3-Fluoro-2-hydroxybenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

Less

3-Fluoro-2-hydroxybenzaldehyde Suppliers

Americas 1 Canada 1 China 213 Europe 3 France 1 Germany 3 India 8 Italy 1 Japan 1 Switzerland 1 Ukraine 1 United Kingdom 16 United States 44 Global 294

Tianjin Wizard Science and Technology Co., Ltd.

Tel: 22-22-58620773 18102163693
Fax: 86-22-58620773
Email: tjchemwizard@163.com
Country: China
ProdList: 94
Advantage: 55

Hubei Deli Pharmaceutical Technology Co., Ltd

Tel: 13372285931
Email: 52519240@qq.com
Country: China
ProdList: 95
Advantage: 58

Shaanxi Renheng Yide Biotechnology Co., Ltd

Tel: 15319940549
Email: 241757027@qq.com
Country: China
ProdList: 113
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16075
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Beijing Eternalchem Co,. Ltd.

Tel: 010-59484199 18611897322
Email: sales@eternalchem.com
Country: China
ProdList: 4383
Advantage: 60

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

PSN Pharmaceutical Technology Co., Ltd.

Tel: 86-25-57062118
Fax: 86-25-57065896
Email: sales@jspsn.com
Country: China
ProdList: 496
Advantage: 57

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Wuhan Arike Technology Co., Ltd.

Tel: 027- 51832457 94518350
Fax: E-Mail Inquiry
Country: China
ProdList: 746
Advantage: 62

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Nanjing Vital Chemical Co., Ltd.

Tel: Please Send Email 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 4378
Advantage: 65

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

ZhengZhou HuaWen Chemical Co.Ltd

Tel: 0370-2785118 17550508557
Fax: QQ：3470079902
Email: 675141927@qq.com
Country: China
ProdList: 3199
Advantage: 55

Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.

Tel: 022-60116533 13207668525
Fax: 022-60979672
Email: saleskc@scipharmacn.com
Country: China
ProdList: 603
Advantage: 58

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

Tianjin Ji Ping Jia Chemical Co., Ltd.

Tel: 18622448868
Fax: 022-58620773
Email: jpjchem@163.com
Country: China
ProdList: 490
Advantage: 62

Shanghai Chainpharm Bio-medical Technology Co., Ltd.

Tel: +86-021-61727342 13611721451
Fax: 021-61294107
Email: chainpharm@163.com
Country: China
ProdList: 980
Advantage: 58

Huainan Kedi Chemical Factory

Tel: 0554-2106669
Fax: 0554-2666215
Email: sales1@kedichem.com
Country: China
ProdList: 4924
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

ShangHai KenEn Chemical Technology Co., Ltd.

Tel: 13120367189
Fax: 021-50315529
Email: mychess007@163.com
Country: China
ProdList: 1994
Advantage: 55

Credit-Chem Co., Ltd.

Tel: 400-821-5857 021-64326257
Fax: 021-64393586 QQ;2798200800
Email: credit-chem@foxmail.com
Country: China
ProdList: 5219
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Tianjin Anhao Biological Technology Co., Ltd.

Tel
Email: sales@ahpharmatech.com
Country: China
ProdList: 5734
Advantage: 55

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 14912
Advantage: 59

Shanghai Synteam Biochem CO.,ltd

Tel: +86-021-58380978 13482386415
Fax: 021-58380978
Email: info@systeambc.com
Country: China
ProdList: 896
Advantage: 50

Shanghai Tombiopharma Chemical Co. Ltd.

Tel: 13391076197
Email: tombiopharma@163.com
Country: China
ProdList: 4987
Advantage: 55

Less

View Lastest Price from 3-Fluoro-2-hydroxybenzaldehyde manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3-Fluoro-2-hydroxybenzaldehyde 394-50-3
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-15

R&D Scientific Inc.

Product: 3-Fluorosalicylaldehyde 394-50-3
Price: US $430.00/g
Min. Order: 1g
Purity: 97
Supply Ability: 500 Kg
Release date: 2024-02-14

Honest Joy Holdings Limited

Product: 3-Fluoro-2-hydroxybenzaldehyde 394-50-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.1%
Supply Ability: 100 tons
Release date: 2022-02-21

394-50-3, 3-Fluoro-2-hydroxybenzaldehydeRelated Search:

3-Fluoro-2-hydroxybenzaldehyde 3,4-Difluoro-2-methoxybenzoic acid 3,5-DIFLUORO-2-METHOXYBENZOIC ACID 3,4-DIFLUORO-2-HYDROXYBENZOIC ACID 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE 3-FLUORO-2-METHOXYBENZALDEHYDE 3,5-DIFLUORO-2-METHOXYBENZALDEHYDE 3-FLUORO-2-METHOXYBENZOIC ACID 3-FLUORO-2-HYDROXYBENZOIC ACID 3,5-Difluoro-4-hydroxybenzaldehyde 5-Fluorosalicylaldehyde 4-FLUORO-2-HYDROXYBENZALDEHYDE,4-FLUOROSALICYLALDEHYDE (4-FLUORO-2-HYDROXYBENZALDEHYDE) 2,6-DIFLUORO-4-HYDROXYBENZALDEHYDE 2-FLUORO-6-HYDROXYBENZALDEHYDE,2-Fluoro-6-hydroxybenzaldehyde 98% 3-FLUORO-4-HYDROXYBENZALDEHYDE 2-FLUORO-4-HYDROXYBENZALDEHYDE 2-FLUORO-5-HYDROXYBENZALDEHYDE Salicylaldehyde

3-FLUOROSALICYLALDEHYDE

3-FLUORO-2-HYDROXYBENZALDEHYDE

3-Fluoro-2-Hydroxybenzaldehyde 3-Fluoro Salicylaldehyde

3-Fluorosalicylaldehyde,98%

1-Fluoro-6-formylphenol

3-Fluoro-2-hydroxybenzaldehyde ,99%

2-Hydroxy-3-fluorobenzaldehyde

3-fluorosalicyldadehyde

3-Fluorosalicylaldehyde ,99%

3-Fluoro-2-hydroxybe

3-Fluorosalicylaldehyde, 2-Fluoro-6-formylphenol

3-Fluorosalicylaldehyde&gt

Benzaldehyde, 3-fluoro-2-hydroxy-

5-Fluoro-3-nitroacetophenone

3-Fluoro-2-hydroxybenzaldehyde1

394-50-3

94-50-3

FC6H32OHCHO

ALDEHYDE

Carbonyl Compounds

Building Blocks

Aldehydes

Organic Building Blocks

Aldehydes

Carbonyl Compounds

Aryl

Hydroxy

Organohalides

Benzenes

Fluorobenzene

Aromatic Aldehydes & Derivatives (substituted)