3-Fluoro-2-hydroxybenzaldehyde
- Product Name
- 3-Fluoro-2-hydroxybenzaldehyde
- CAS No.
- 394-50-3
- Chemical Name
- 3-Fluoro-2-hydroxybenzaldehyde
- Synonyms
- 3-FLUOROSALICYLALDEHYDE;3-Fluoro-2-hydroxybe;3-fluorosalicyldadehyde;1-Fluoro-6-formylphenol;3-Fluorosalicylaldehyde>3-Fluorosalicylaldehyde,98%;3-Fluorosalicylaldehyde ,99%;5-Fluoro-3-nitroacetophenone;3-FLUORO-2-HYDROXYBENZALDEHYDE;2-Hydroxy-3-fluorobenzaldehyde
- CBNumber
- CB1367319
- Molecular Formula
- C7H5FO2
- Formula Weight
- 140.11
- MOL File
- 394-50-3.mol
3-Fluoro-2-hydroxybenzaldehyde Property
- Melting point:
- 68-70 °C(lit.)
- Boiling point:
- 176.2±20.0 °C(Predicted)
- Density
- 1.350±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, stored under nitrogen
- Water Solubility
- Insoluble in water
- pka
- 6.91±0.10(Predicted)
- form
- Crystalline Powder
- color
- White to light yellow
- Sensitive
- Air Sensitive
- BRN
- 1932806
- InChI
- InChI=1S/C7H5FO2/c8-6-3-1-2-5(4-9)7(6)10/h1-4,10H
- InChIKey
- NWDHTEIVMDYWQJ-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC=CC(F)=C1O
- CAS DataBase Reference
- 394-50-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 319805
- Product name
- 3-Fluorosalicylaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $94.7
- Updated
- 2022/05/15
- Product number
- 319805
- Product name
- 3-Fluorosalicylaldehyde
- Purity
- 97%
- Packaging
- 250mg
- Price
- $95.5
- Updated
- 2022/05/15
- Product number
- F0625
- Product name
- 3-Fluorosalicylaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $70
- Updated
- 2025/07/31
- Product number
- F0625
- Product name
- 3-Fluorosalicylaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $204
- Updated
- 2025/07/31
- Product number
- F598025
- Product name
- 3-Fluoro-2-hydroxybenzaldehyde
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
3-Fluoro-2-hydroxybenzaldehyde Chemical Properties,Usage,Production
Chemical Properties
White to light yellow crystalline powder
Synthesis Reference(s)
Journal of the American Chemical Society, 68, p. 2502, 1946 DOI: 10.1021/ja01216a020
Synthesis
109-72-8
98015-07-7
394-50-3
A hexane solution of n-butyllithium (17.07 mL, 1.42 M, 25.1 mmol) was slowly added dropwise to a stirred solution of 2-(2-bromo-5-methoxyphenyl)-1,3-dioxolane (5.00 g, 19.3 mmol) dissolved in dry tetrahydrofuran (60 mL) at -78°C. The reaction mixture was stirred continuously at -78 °C for 30 min before being quenched by the addition of iodomethane (2.40 mL, 38.6 mmol). After quenching, the solution was continued stirring at -78 °C for 20 min, followed by termination of the reaction with saturated aqueous ammonium chloride solution (60 mL). The organic phase was separated, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast column chromatography using hexane:ethyl acetate (10:1) as eluent to afford the light yellow oily target product 3-fluoro-2-hydroxybenzaldehyde (3.07 g, 82% yield). Thin layer chromatography showed an Rf value of 0.40 (Expanding agent: hexane:ethyl acetate, 10:1). The NMR hydrogen spectrum (300 MHz, CDCl3) data were as follows: δ 7.20-6.99 (2H, m, Ar-H), 6.75 (1H, dd, Ar-H), 5.92 (1H, s, CH), 4.20-4.01 (4H, m, 2 × CH2), 3.80 (3H, s, OCH3), 2.32 (3H, s, CH3) .
References
[1] Patent: WO2004/43903, 2004, A1. Location in patent: Page 31
3-Fluoro-2-hydroxybenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
3-Fluoro-2-hydroxybenzaldehyde Suppliers
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- Country
- Ukraine
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View Lastest Price from 3-Fluoro-2-hydroxybenzaldehyde manufacturers
- Product
- 3-Fluoro-2-hydroxybenzaldehyde 394-50-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-15
- Product
- 3-Fluorosalicylaldehyde 394-50-3
- Price
- US $430.00/g
- Min. Order
- 1g
- Purity
- 97
- Supply Ability
- 500 Kg
- Release date
- 2024-02-14
- Product
- 3-Fluoro-2-hydroxybenzaldehyde 394-50-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.1%
- Supply Ability
- 100 tons
- Release date
- 2022-02-21