The intermediate of Vitamin E Chemical Properties Uses Production method
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Trimethylhydroquinone

The intermediate of Vitamin E Chemical Properties Uses Production method
Product Name
Trimethylhydroquinone
CAS No.
700-13-0
Chemical Name
Trimethylhydroquinone
Synonyms
1,4-Benzenediol, 2,3,5-trimethyl-;tmhq;2,3,5-TRIMETHYLHYDROQUINONE;-Cumoquinol;2,3,5- trimethyl-1;psi-Cumohydroquinone;Trimethylhydroqninone;TRIMETHYLHYDROQUINONE;trimethyl-hydroquinon;2,3,5-Trimethylquinol
CBNumber
CB1403963
Molecular Formula
C9H12O2
Formula Weight
152.19
MOL File
700-13-0.mol
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Trimethylhydroquinone Property

Melting point:
169-172 °C (lit.)
Boiling point:
295 °C (759.8513 mmHg)
Density 
0.9595 (rough estimate)
vapor pressure 
0-0.017Pa at 20-50℃
refractive index 
1.4464 (estimate)
Flash point:
191 °C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
methanol: 0.1 g/mL, clear
pka
11.28±0.28(Predicted)
form 
Crystalline Powder
color 
Beige
Water Solubility 
2 g/L (20 ºC)
BRN 
1909183
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
AUFZRCJENRSRLY-UHFFFAOYSA-N
LogP
3.32 at 25℃
Dissociation constant
10.8-12.9
CAS DataBase Reference
700-13-0(CAS DataBase Reference)
NIST Chemistry Reference
Trimethylhydroquinone(700-13-0)
EPA Substance Registry System
1,4-Benzenediol, 2,3,5-trimethyl- (700-13-0)
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Safety

Hazard Codes 
Xn,N
Risk Statements 
20-37/38-41-43-50/53
Safety Statements 
24-26-37/39-60-61
RIDADR 
UN 3077 9/PG 3
WGK Germany 
2
RTECS 
MX7820000
F 
9-23
TSCA 
Yes
HazardClass 
9
PackingGroup 
III
HS Code 
29072990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H332Harmful if inhaled

H335May cause respiratory irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T76503
Product name
Trimethylhydroquinone
Purity
97%
Packaging
100g
Price
$72.7
Updated
2024/03/01
Sigma-Aldrich
Product number
T76503
Product name
Trimethylhydroquinone
Purity
97%
Packaging
500g
Price
$113
Updated
2024/03/01
TCI Chemical
Product number
T0477
Product name
Trimethylhydroquinone
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$47
Updated
2024/03/01
TCI Chemical
Product number
T0477
Product name
Trimethylhydroquinone
Purity
>98.0%(GC)(T)
Packaging
100g
Price
$134
Updated
2024/03/01
Alfa Aesar
Product number
B22819
Product name
Trimethylhydroquinone
Purity
98%
Packaging
100g
Price
$45.65
Updated
2024/03/01
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Trimethylhydroquinone Chemical Properties,Usage,Production

The intermediate of Vitamin E

Trimethylhydroquinone and isophytol are two intermediate in the synthesis of vitamin E, currently trimethylhydroquinone in world market is mainly produced by BASF and Roche, it can not meet the needs of vitamin E. The 2,3,5-trimethyl hydroquinone of China is put into operation by only a few companies, China has become the world's second largest feed production country, if the amount of vitamin E in animal feed reach the average level of foreign words, the annual consumption vitamin E is nearly 2000t. According to Chinese feed industry planning, the amount of feed demand synthetic vitamin E is about 2500t in 2005. Furthermore, the needs of vitamin E in pharmaceutical, food, cosmetics and other needs for vitamin E will grow steadily in the future. So in the last ten years, or even 20 years, the future market 2,3,5-trimethyl hydroquinone can not be not saturated. The development of this project has broad application prospects.
Vitamin E is not only used as a medicine, feed, food, cosmetic additives, but also get more and more applications in industry, such as industrial antioxidants, polyolefin non-toxic, biodegradable stabilizer. A sharp increase in domestic and international market demand for vitamin E is present. The naturally occurring vitamin E is very limited, so timely start-up and expansion of production of vitamin E will bring better economic benefits.
The above information is edited by the chemicalbook of Wang Xiaodong.

Chemical Properties

It is crystalline solid. When heated, it can sublimate, when esposed to moisture, it can turn black easily. It can be slightly soluble in water, soluble in ethyl alcohol, insoluble in petroleum ether. Melting point is 173℃.

Uses

The product is main ring of vitamin E, it can condensation with isophytol to get vitamin E.
Organic intermediates, pharmaceutical intermediates, it can be used for the synthesis of VE.

Production method

By sulfonation, nitration, reduction, oxidation 1,2,4-trimethylbenzene can get 2,3,5-trimethyl benzoquionone ([935-92-2]). 2,3,5-trimethyl benzoquionone is yellow needle crystallization, melting point is 32℃ (38-29.5℃), the boiling point is 53℃(53Pa). Said step of products are generally to obtain a solution of petroleum ether or gasoline. In 2,3,5-trimethyl gasoline solution (petroleum ether), hydrosulfite solution is added with stirring, stir at room temperature for 3h, then filter, the cake should be washed with 0.5% hydrosulfite solution, and then dry to get trimethyl hydroquinone.

Chemical Properties

off-white, tan or orange powder

Uses

Trimethylhydroquinone is used for synthesizing vitamin E and used as medical intermediate.

Uses

Trimethylhydroquinone is a key precursor for the synthesis of tocopherols (vitamin E) and (±)-madindolines.

Definition

ChEBI: 2,3,5-trimethylhydroquinone is a member of the class of hydroquinones that is hydroquinone substituted by methyl groups at positions 2, 3 and 5. It is a member of hydroquinones and a methylbenzene.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 16, p. 378, 1968 DOI: 10.1248/cpb.16.378

Safety Profile

Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Recrystallise the hydroquinone from water, under anaerobic conditions. [Beilstein 6 H 931, 6 IV 5997.]

Trimethylhydroquinone Preparation Products And Raw materials

Raw materials

1,2,4-Trimethylbenzene Sodium dithionite

Preparation Products

Tocopheryl acetate Vitamin E D-alpha-Tocopheryl acetate Vitamin E Seratrodast
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Trimethylhydroquinone Suppliers

Belgium 3 China 289 Europe 3 France 1 Germany 7 India 17 Japan 8 Russia 1 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 United Kingdom 14 United States 40 Global 388
HBCChem, Inc.
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View Lastest Price from Trimethylhydroquinone manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Trimethylhydroquinone 700-13-0
Price
US $45.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/Week
Release date
2024-05-10
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Trimethylhydroquinone 700-13-0
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-30
Hebei Weibang Biotechnology Co., Ltd
Product
Trimethylhydroquinone 700-13-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-29

700-13-0, TrimethylhydroquinoneRelated Search:

Quinhydrone 1,4-Dimethoxybenzene 2,6-DIMETHYLHYDROQUINONE VITAMIN K4 Trimethyl-pyrazine tert-Butylhydroquinone Mesitylene 2-Methylhydroquinone 2,3,5-Trimethylphenol 2,3,5-Collidine Hydroquinone Trimethyl phosphate Trimethylolpropane Trimethyl orthoacetate Trimethylamine Trimethylamine hydrochloride DL-ALPHA-TOCOPHEROL HYDROGEN SUCCINATE Vitamin E nicotinate

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  • TRIMETHYLHYDROQUINONE
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  • 2,3,5-TRIMETHYL-BENZENE-1,4-DIOL
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  • 1,4-Benzenediol, 2,3,5-trimethyl-
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  • 2,3,5-Trimethyl-1,4-benzenediol
  • 2,3,5-trimethyl-4-benzenediol
  • 2,3,5-TRIMETHYLHYDROQUINONE
  • 1,4-DIHYDROXY-2,3,5-TRIMETHYLBENZENE
  • 2,3,5-Trimethylquinol
  • Trimethylhydroquinone, 98+%
  • 1,4-Dihydroxy-2,3,5-trimethylbenzene, 3,6-Dihydroxypseudocumene
  • TriMethylhydroquinone, 97% 100GR
  • 2,3,6-Trimethylhydroquinone
  • 2,3,6-Trimethylhydrochinon
  • Trimethylhydroquinone,97%
  • Three Methyl hydroquinone
  • Trimethylhydroquinone≥99%
  • 1,4-Dihydroxy-2,3,5-trimethylbenzene 3,6-Dihydroxypseudocumene 2,3,5-Trimethylhydroquinone
  • Trimethylhydroquinone &gt
  • 2,3,5-TRIMETHYL HYDROQUINONE (TMHQ)
  • 2,3,5- trimethyl-1
  • 2,3,5-Trimethyl-p-hydroquinone
  • 700-13-0
  • CH33C6H14OH2
  • C6HCH33OH2
  • Polyols
  • Oxygen Compounds
  • Organic Building Blocks
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  • Organic Building Blocks
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