ChemicalBook > CAS DataBase List > Fmoc-Lys(Boc)-OH

Fmoc-Lys(Boc)-OH

Product Name
Fmoc-Lys(Boc)-OH
CAS No.
71989-26-9
Chemical Name
Fmoc-Lys(Boc)-OH
Synonyms
FMOC-LYS(BOC)-OH;FMOC-LYS(BOC);FMOC-L-LYS(BOC)-OH;FMOC-D-LYS(BOC);fmoc-lys(boc)-o;FMOC-L-LYS(BOC);Fmoc-L-Lysine(Boc)-OH;Nα-Fmoc-Nε-Boc-L-lysine;Nα-Fmoc-Nε-Boc-L-lysine;N6-(TERT-BUTOXYCARBONYL)-N2-((9H-FLUOREN-9-YLMETHOXY)CARBONYL)-L-LYSINE
CBNumber
CB1451227
Molecular Formula
C26H32N2O6
Formula Weight
468.54
MOL File
71989-26-9.mol
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Fmoc-Lys(Boc)-OH Property

Melting point:
130-135 °C (dec.)
alpha 
-12 º (c=2,DMF 24 ºC)
Boiling point:
570.69°C (rough estimate)
Density 
1.2301 (rough estimate)
refractive index 
-12 ° (C=1, DMF)
storage temp. 
Store below +30°C.
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka
3.88±0.21(Predicted)
form 
Powder
color 
White
optical activity
[α]20/D 12±1°, c = 1% in DMF
Water Solubility 
Slightly soluble in water.
BRN 
4217767
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
UMRUUWFGLGNQLI-QFIPXVFZSA-N
CAS DataBase Reference
71989-26-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Safety Statements 
24/25-36/37/39-27-26
WGK Germany 
3
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.52012
Product name
Fmoc-Lys(Boc)-OH
Purity
Novabiochem?
Packaging
25g
Price
$72.8
Updated
2024/03/01
Sigma-Aldrich
Product number
8.52012
Product name
Fmoc-Lys(Boc)-OH
Purity
Novabiochem?
Packaging
100g
Price
$183
Updated
2024/03/01
Sigma-Aldrich
Product number
8.52012
Product name
Fmoc-Lys(Boc)-OH
Purity
Novabiochem?
Packaging
250g
Price
$365
Updated
2024/03/01
Sigma-Aldrich
Product number
8.52012
Product name
Fmoc-Lys(Boc)-OH
Purity
Novabiochem?
Packaging
1kg
Price
$1370
Updated
2024/03/01
Sigma-Aldrich
Product number
47624
Product name
Fmoc-Lys(Boc)-OH
Purity
≥98.0% (HPLC)
Packaging
1G
Price
$28.5
Updated
2024/03/01
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Fmoc-Lys(Boc)-OH Chemical Properties,Usage,Production

Description

Fmoc-Lys(Boc)-OH (Na-Fmoc-Ne-Boc-L-lysine) has emerged as the standard Fmoc-Lys derivative used in peptide synthesis. The Boc group on the side chain is stable under basic conditions and remains in place even through many Fmoc deprotection cycles. The Boc group of Fmoc-Lys(Boc)-OH is readily removed with trifluoroacetic acid (TFA) during cleavage of the peptide product from Wang resin or Rink amide resin. It could self-assemble to sphere like morphology in all conditions irrespective of concentration and heating. To prepare the FAPI-04 dimer complex, this compound could used as a linker to conjugate two FAPI-04 structures by an amide reaction. After further modification, the product can perform cancer theranostics[1-2].

Chemical Properties

white to light yellow crystal powde

Uses

It is used to prepare dimeric RGD peptide-paclitaxel conjugate as model for integrin-targeted drug delivery. It is also used to synthesize DOTA-conjugated multivalent cyclic-RGD peptide dendrimers for tumor targeting and imaging use.

Uses

Fmoc-Lys(Boc)-OH can be used for:

  • The solid-phase synthesis of pentasubstituted dihydroimidazolylbutyl dihydroimidazol-3-ium salts by coupling with p-methylbenzhydrylamine (MBHA) resin.
  • Fmoc-based peptide synthesis of bis-naphthalene diimide, a threading intercalator.
  • Synthesis of ε-Boc-ε-(3,5-bis-trifluoromethyl-benzyl)-α-Fmoc-L-Lysine to be used as 19F NMR based screening tool.

References

[1] Gour N, et al. Controlled aggregation properties of modified single amino acids. ChemRxiv, 2021; 46.
[2] Zhong X, et al. Synthesis and Preclinical Evaluation of a Novel FAPI-04 Dimer for Cancer Theranostics. Molecular Pharmaceutics, 2023; 20: 2402–2414.

Fmoc-Lys(Boc)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Fmoc-Lys(Boc)-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Fmoc-L-Lys(Boc)-OH 71989-26-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T
Release date
2023-11-29
WUHAN FORTUNA CHEMICAL CO., LTD
Product
N-alpha-FMOC-Nepsilon-BOC-L-Lysine 71989-26-9
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99.5%min
Supply Ability
500KGS
Release date
2021-06-23
Wuhan Senwayer Century Chemical Co.,Ltd
Product
Fmoc-Lys(Boc)-OH 71989-26-9
Price
US $0.00/gram
Min. Order
25gram
Purity
99% min
Supply Ability
20 tons
Release date
2023-10-16

71989-26-9, Fmoc-Lys(Boc)-OHRelated Search:

Fmoc-Aib-OH 9-Fluorenylmethyl chloroformate N-(9-Fluorenylmethoxycarbonyloxy)succinimide L-Lysine AC-HIS-OH H2O Cbz-beta-Amino-L-alanine DI-TERT-BUTYL ETHER FMOC-Ala-OH FMOC-S-trityl-L-cysteine Fmoc-Asp(OtBu)-OH FMOC-L-Valine FMOC-L-Methionine FMOC-N-METHYL-TRANEXAMIC ACID Fmoc-L-Tyr(propargyl)-OH Fmoc-Gly-OH FMOC-O-tert-Butyl-L-serine Fmoc-Asn(Trt)-OH FMOC-TRANEXAMIC ACID

  • N<sup>α</sup>-FMoc-N<sup>ε</sup>-Boc-L-lysine
  • (S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-6-((tert-butoxycarbonyl)aMino)hexanoic acid
  • N^e-Boc-N^a-FMoc-L-lysine, 98%
  • ALPHA-FMOC-EPSILON-BOC-LYSINE
  • fmoc-lys(boc)-o
  • Nα-Fmoc-Nε-Boc-L-lysine
  • L-LYSINE, N6-[(1,1-DIMETHYLETHOXY)CARBONYL]-N2-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-
  • FMOC-D-LYS(BOC)
  • FMOC-D-LYSINE(BOC)-OH
  • FMOC-L-LYS(TBOC)-OH
  • FMOC-L-LYS(BOC)
  • FMOC-L-LYS(BOC)-OH
  • FMOC-L-LYSINE(BOC)
  • FMOC-L-LYSINE (TBOC)
  • FMOC-N-EPSILON-BOC-D-LYSINE
  • FMOC-N-EPSILON-BOC-L-LYSINE
  • FMOC-LYS(BOC)-OH
  • FMOC-LYS(BOC)
  • FMOC-LYSINE(BOC)-OH
  • N<SUB>α</SUB>-Fmoc-Nε-Boc-L-lysine
  • Fmoc-(Boc)lysine
  • Fmoc-Lys(Boc)-OH (N-Alpha-Fmoc-N-Epsilon-Boc-L-Lysine)
  • N-alpha-FMOC-Nepsilo
  • Nalpha-FMOC-Nepsilon-BOC-L-Lysine,99%
  • L-LYSINE-ALPHA-N-FMOC, EPSILON-N-T-BOC
  • Nepsilon-Boc-Nalpha-Fmoc-L-lysine Fmoc-Lys(Boc)-OH
  • Fmoc-Iys(Boc)-OH
  • (9H-Fluoren-9-yl)MethOxy]Carbonyl Lys(Boc)-OH
  • Fomc-Lys(B
  • ys(Boc)-OH
  • FMoc-Lys(Boc)-OH >=98.0% (HPLC)
  • Fmoc-Lys(Boc)-OH(CAS:71989-26-9)
  • L-LYSINE-ALPHA-N-FMOC, EPSILON-N-T-BOC (13C6
  • L-LYSINE-ALPHA-N-FMOC, EPSILON-N-T-BOC (1-13C)
  • Nε-(tert-Butoxycarbonyl)-Nα-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine
  • (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid
  • Nα-Fmoc-Nε-Boc-L-lysine≥ 99.5% (HPLC, Chiral purity)
  • N-α-FMOC-N-&epsi:-BOC-L-lysine
  • N-ALPHA-FMOC-N-EPSILON-BOC-D-LYSINE
  • N-ALPHA-FMOC-N-EPSILON-BOC-L-LYSINE
  • N-ALPHA-FMOC-N-EPSILON-T-BOC-D-LYSINE
  • N-ALPHA-FMOC-N-EPSILON-T-BOC-L-LYSINE
  • N-ALPHA-FMOC-N-EPSILON-T-BUTYLOXYCARBONYL-D-LYSINE
  • N-ALPHA-FMOC-N-EPSILON-T-BUTYLOXYCARBONYL-L-LYSINE
  • N-ALPHA-FMOC-N-EPSILON-TERT-BOC-D-LYSINE
  • N-ALPHA-FMOC-N-EPSILON-TERT-BOC-L-LYSINE
  • N-ALPHA-FMOC-T-BOC-L-LYS
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-EPSILON-T-BUTYLOXYCARBONYL-L-LYSINE
  • NEPSILON-tert-Butoxycarbonyl-NALPHA-9-fluorenylmethoxycarbonyl-L- lysine
  • FMOC-N-(EPSILON)-BOC-L-LYSINE (FMOC-L-LYS(BOC)-OH)
  • FMOC-N-E-BOC-L-LYSINE
  • N-α-Fmoc-N-ε-t.-Boc-L-lysine
  • L-Lysine-UL-13C6, 15N2-α-N-FMOC, ε-N-t-BOC
  • L-Lysine-1-13C-α-N-FMOC, ε-N-t-BOC
  • N6-(TERT-BUTOXYCARBONYL)-N2-((9H-FLUOREN-9-YLMETHOXY)CARBONYL)-L-LYSINE
  • NA-FMOC-N-E-BOC-L-LYSINE
  • N-ALPHA-9-FLUORENYLMETHOXYCARBONYL-N-EPSILON-T-BUTYLOXYCARBONYL-L-LYSINE
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-EPSILON-(TERT-BUTOXYCARBONYL)-L-LYSINE