PROTAC K-Ras Degrader-1

Product Name: PROTAC K-Ras Degrader-1
CAS No.: 2378258-52-5
Chemical Name: PROTAC K-Ras Degrader-1
Synonyms: K-Ras Degrader-1;PROTAC K-Ras Degrader-1;2-Piperazineacetonitrile, 4-[2-[[(2S,4R)-4-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-1-methyl-2-pyrrolidinyl]methoxy]-5,6,7,8-tetrahydro-7-(1-naphthalenyl)pyrido[3,4-d]pyrimidin-4-yl]-1-(1-oxo-2-propen-1-yl)-, (2S)-
CBNumber: CB15540584
Molecular Formula: C53H62N10O10
Formula Weight: 999.14
MOL File: 2378258-52-5.mol

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PROTAC K-Ras Degrader-1 Property

Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 33.33 mg/mL (33.36 mM)
pka: 10.74±0.40(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0106329
Product name: PROTACK-RasDegrader-1
Purity: 98.05%
Packaging: 1mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0106329
Product name: PROTACK-RasDegrader-1
Purity: 98.05%
Packaging: 5mg
Price: $1500
Updated: 2021/12/16

ChemScene

Product number: CS-0106329
Product name: PROTACK-RasDegrader-1
Purity: 98.05%
Packaging: 10mg
Price: $2500
Updated: 2021/12/16

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PROTAC K-Ras Degrader-1 Chemical Properties,Usage,Production

Description

PROTAC K-Ras Degrader-1 (Compound 518) is potent K-Ras degrader based PROTAC, exhibits ≥70% degradation efficacy in SW1573 cells[1].

References

[1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.

PROTAC K-Ras Degrader-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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PROTAC K-Ras Degrader-1 Suppliers

China 7 United States 1 Global 8

Jilin Province Woda Biotechnology Co., Ltd.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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cjbscvictory

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Changzhou Bojia Biomedical Technology Co., Ltd.

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ShenZhen Trendseen Biological Technology Co.,Ltd.

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Nantong QuanYi Biotechnology Co., Ltd

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Shanghai Hao Zhun Biological Technology Co., Ltd.

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PROTAC K-Ras Degrader-1

K-Ras Degrader-1

2-Piperazineacetonitrile, 4-[2-[[(2S,4R)-4-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-1-methyl-2-pyrrolidinyl]methoxy]-5,6,7,8-tetrahydro-7-(1-naphthalenyl)pyrido[3,4-d]pyrimidin-4-yl]-1-(1-oxo-2-propen-1-yl)-, (2S)-

2378258-52-5