DBCO-PEG6-amine,DBCO-PEG6-NH2

Product Name: DBCO-PEG6-amine,DBCO-PEG6-NH2
CAS No.: 2353409-98-8
Chemical Name: DBCO-PEG6-amine,DBCO-PEG6-NH2
Synonyms: DBCO-PEG6-amine TFA salt;DBCO-PEG6-amine,DBCO-PEG6-NH2;Dibenz[b,f]azocine-5(6H)-butanamide, N-(20-amino-3,6,9,12,15,18-hexaoxaeicos-1-yl)-11,12-didehydro-γ-oxo-
CBNumber: CB15840394
Molecular Formula: C33H45N3O8
Formula Weight: 611.74
MOL File: 2353409-98-8.mol

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DBCO-PEG6-amine,DBCO-PEG6-NH2 Property

Boiling point:: 823.0±65.0 °C(Predicted)
Density: 1.22±0.1 g/cm3(Predicted)
solubility: Soluble in Water, DMSO, DCM, DMF
pka: 15.14±0.46(Predicted)
form: Solid-Liquid Mixture
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-24151
Product name: DBCO-PEG6-amineTFAsalt
Purity: 98%
Packaging: 50mg
Price: $350
Updated: 2021/12/16

BroadPharm

Product number: BP-24151
Product name: DBCO-PEG6-amineTFAsalt
Purity: 98%
Packaging: 100mg
Price: $560
Updated: 2021/12/16

BroadPharm

Product number: BP-24151
Product name: DBCO-PEG6-amineTFAsalt
Purity: 98%
Packaging: 250mg
Price: $890
Updated: 2021/12/16

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DBCO-PEG6-amine,DBCO-PEG6-NH2 Chemical Properties,Usage,Production

Description

DBCO-PEG6-amine is a PEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases the water solubility of the compound.

Uses

DBCO-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG6-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

DBCO-PEG6-amine,DBCO-PEG6-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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DBCO-PEG6-amine,DBCO-PEG6-NH2 Suppliers

China 16 United States 3 Global 19

Hangzhou J&H Chemical Co., Ltd.

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2353409-98-8, DBCO-PEG6-amine,DBCO-PEG6-NH2Related Search:

DBCO-PEG6-amine,DBCO-PEG6-NH2

DBCO-PEG6-amine TFA salt

Dibenz[b,f]azocine-5(6H)-butanamide, N-(20-amino-3,6,9,12,15,18-hexaoxaeicos-1-yl)-11,12-didehydro-γ-oxo-

2353409-98-8