DBCO-PEG4-NH-Boc

Product Name: DBCO-PEG4-NH-Boc
CAS No.: 2353410-17-8
Chemical Name: DBCO-PEG4-NH-Boc
Synonyms: DBCO-PEG4-Boc Amine;DBCO-PEG4-t-Bu Amine;5,8,11,14-Tetraoxa-2,17-diazaheneicosanoic acid, 21-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-18,21-dioxo-, 1,1-dimethylethyl ester
CBNumber: CB58054699
Molecular Formula: C34H45N3O8
Formula Weight: 623.74
MOL File: 2353410-17-8.mol

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DBCO-PEG4-NH-Boc Property

Boiling point:: 840.5±65.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
solubility: Soluble in DMSO, DCM, DMF
pka: 12.23±0.46(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-24105
Product name: DBCO-PEG4-NH-Boc
Purity: 98%
Packaging: 250mg
Price: $850
Updated: 2021/12/16

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DBCO-PEG4-NH-Boc Chemical Properties,Usage,Production

Description

DBCO-PEG4-NH-Boc is a PEG linker with a DBCO group and a Boc-protected amine. The DBCO can undergo copper-free Click Chemistry reactions with azides. The Boc protecting group can be removed under acidic conditions to further react. The hydrophilic PEG linker increases the water solubility of the compound.

Uses

DBCO-PEG4-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG4-NH-Boc is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

DBCO-PEG4-NH-Boc Preparation Products And Raw materials

Raw materials

Preparation Products

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DBCO-PEG4-NH-Boc Suppliers

China 16 United States 2 Global 18

TargetMol Chemicals Inc.

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2353410-17-8, DBCO-PEG4-NH-BocRelated Search:

DBCO-PEG4-amine DBCO-PEG1-acid DBCO-PEG6-amine,DBCO-PEG6-NH2 DBCO-PEG4-NH-Boc Azadibenzocyclooctyne-PEG12-N-hydroxysuccinimidyl ester DBCO-PEG2-amine DBCO-Acid Azadibenzocyclooctyne-Biotin conjugate DBCO-PEG1 DBCO-PEG12-acid

DBCO-PEG4-t-Bu Amine

5,8,11,14-Tetraoxa-2,17-diazaheneicosanoic acid, 21-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-18,21-dioxo-, 1,1-dimethylethyl ester

DBCO-PEG4-Boc Amine

2353410-17-8