DBCO-PEG2-amine

Product Name: DBCO-PEG2-amine
CAS No.: 2250216-96-5
Chemical Name: DBCO-PEG2-amine
Synonyms: DBCO-PEG2-amine
CBNumber: CB44849575
Molecular Formula: C25H29N3O4
Formula Weight: 435.52
MOL File: 2250216-96-5.mol

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DBCO-PEG2-amine Property

Boiling point:: 748.9±60.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
solubility: Soluble in DMSO, DCM, DMF
pka: 15.14±0.46(Predicted)
InChI: InChI=1S/C25H29N3O4/c26-13-15-31-17-18-32-16-14-27-24(29)11-12-25(30)28-19-22-7-2-1-5-20(22)9-10-21-6-3-4-8-23(21)28/h1-8H,11-19,26H2,(H,27,29)
InChIKey: ILEXOUGGKQHBOX-UHFFFAOYSA-N
SMILES: C(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)(=O)CCC(=O)NCCOCCOCCN

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-24152
Product name: DBCO-PEG2-amineTFAsalt
Purity: 98%
Packaging: 50mg
Price: $350
Updated: 2021/12/16

BroadPharm

Product number: BP-24152
Product name: DBCO-PEG2-amineTFAsalt
Purity: 98%
Packaging: 100mg
Price: $560
Updated: 2021/12/16

BroadPharm

Product number: BP-24152
Product name: DBCO-PEG2-amineTFAsalt
Purity: 98%
Packaging: 250mg
Price: $890
Updated: 2021/12/16

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DBCO-PEG2-amine Chemical Properties,Usage,Production

Description

DBCO-PEG2-amine is a PEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases the water solubility of the compound.

Uses

DBCO-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG2-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

DBCO-PEG2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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DBCO-PEG2-amine Suppliers

China 22 United States 3 Global 25

Suzhou Derivative Biotechnology Co., Ltd.

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Shanghai Macklin Biochemical Co.,Ltd.

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Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

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TargetMol Chemicals Inc.

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Shaanxi Xinyan Bomei Biotechnology Co., Ltd.

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Shanghai Minhan Pharmaceutical Technology Co., Ltd.

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Guangzhou Younan Technology Co., Ltd

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Zhende Chemical Technology (Shanghai) Co., Ltd.

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Zhengzhou Akem Chemical Co., Ltd

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2250216-96-5, DBCO-PEG2-amineRelated Search:

DBCO-PEG9-amine N-DBCO-N-bis(PEG2-acid) m-PEG4-DBCO DBCO-PEG6-amine,DBCO-PEG6-NH2 DBCO-PEG3-OH DBCO-PEG4-triethoxysilane Propanoic acid, 3-[2-[2-[[4-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-1,4-dioxobutyl]amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester 4,7,10,13,16,19,22,25-Octaoxa-28-azadotricosanoic acid, 32-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-29,32-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester DBCO-C6-acid DBCO-PEG4-maleimide DBCO-PEG3-Mal 4,7,10-Trioxa-13-azaheptadecanoic acid, 17-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-14,17-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester DBCO-Acid DBCO-PEG1 DBCO-PEG4-biotin DBCO-NHCO-PEG2-Biotin Ambient temperature 1H-Pyrrole-1-propanamide, N-[2-[2-[3-[[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]amino]-3-oxopropoxy]ethoxy]ethyl]-2,5-dihydro-2,5-dioxo-

DBCO-PEG2-amine

2250216-96-5