DBCO-PEG4-NH-Boc
- Product Name
- DBCO-PEG4-NH-Boc
- CAS No.
- 1255942-12-1
- Chemical Name
- DBCO-PEG4-NH-Boc
- Synonyms
- DBCO-PEG4-NH-Boc;DBCO-NHCO-PEG4-NH-Boc;DBCO-NHCO-PEG4-t-Boc Amine;5,8,11,14-Tetraoxa-2,18-diazaheneicosanoic acid, 21-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-17,21-dioxo-, 1,1-dimethylethyl ester;5,8,11,14-Tetraoxa-2,18-diazaheneicosanoic acid, 21-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-17,21-dioxo-, 1,1-dimethylethyl ester (ACI)
- CBNumber
- CB23373604
- Molecular Formula
- C34H45N3O8
- Formula Weight
- 623.74
- MOL File
- 1255942-12-1.mol
DBCO-PEG4-NH-Boc Property
- Boiling point:
- 840.5±65.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- solubility
- Soluble in DMSO, DCM, DMF
- form
- Viscous Liquid
- pka
- 12.23±0.46(Predicted)
- color
- Colorless to yellow
N-Bromosuccinimide Price
- Product number
- BP-23623
- Product name
- DBCO-NHCO-PEG4-NH-Boc
- Purity
- 98%
- Packaging
- 50mg
- Price
- $280
- Updated
- 2021/12/16
DBCO-PEG4-NH-Boc Chemical Properties,Usage,Production
Description
DBCO-NHCO-PEG4-NH-Boc is a click chemistry reagent. it can undergo copper-free Click Chemistry reactions with azides. The Boc protecting group can be removed under acidic conditions.
Biological Activity
DBCO-NHCO-PEG4-NH-Boc is a PROTAC linker that belongs to the PEG class and the Alkyl/ether class. It can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| PEGs
| Alkyl/ether
|
DBCO-PEG4-NH-Boc Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from DBCO-PEG4-NH-Boc manufacturers
- Product
- DBCO-NHCO-PEG4-NHBoc 1255942-12-1
- Price
- US $0.00/mg
- Min. Order
- 50mg
- Purity
- >95.00%
- Supply Ability
- 250mg
- Release date
- 2024-03-20