Azadibenzocyclooctyne-PEG12-N-hydroxysuccinimidyl ester

Product Name: Azadibenzocyclooctyne-PEG12-N-hydroxysuccinimidyl ester
CAS No.: 2093934-94-0
Chemical Name: Azadibenzocyclooctyne-PEG12-N-hydroxysuccinimidyl ester
Synonyms: DBCO-PEG12-NHS Ester;DBCO-NH-PEG12-CH2CH2COONHS ester;Azadibenzocyclooctyne-PEG12-N-hydroxysuccinimidyl ester;Poly(oxy-1,2-ethanediyl), α-[2-[[4-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-1,4-dioxobutyl]amino]ethyl]-ω-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropoxy]-
CBNumber: CB33309389
Molecular Formula: (C2H4O)nC28H27N3O7
Formula Weight: 0
MOL File: 2093934-94-0.mol

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Azadibenzocyclooctyne-PEG12-N-hydroxysuccinimidyl ester Property

storage temp.: -20°C, protect from light, stored under nitrogen
solubility: Soluble in DMSO, DCM, DMF
form: Oil
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-24149
Product name: DBCO-PEG12-NHSester
Purity: 98%
Packaging: 25mg
Price: $380
Updated: 2021/12/16

BroadPharm

Product number: BP-24149
Product name: DBCO-PEG12-NHSester
Purity: 98%
Packaging: 100mg
Price: $970
Updated: 2021/12/16

purepeg

Product number: 488412
Product name: DBCO-NH-PEG12-CH2CH2COONHSester
Purity: min.95%
Packaging: 100mg
Price: $650
Updated: 2021/12/16

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Azadibenzocyclooctyne-PEG12-N-hydroxysuccinimidyl ester Chemical Properties,Usage,Production

Description

DBCO-PEG12-NHS Ester is a monodisperse PEG linker which enable free copper click chemistry with N3 group. NHS ester moiety can react specifically and efficiently with primary amines to form a covalent amide bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation.

Uses

DBCO-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG12-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Azadibenzocyclooctyne-PEG12-N-hydroxysuccinimidyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Azadibenzocyclooctyne-PEG12-N-hydroxysuccinimidyl ester Suppliers

China 20 United States 5 Global 25

Shanghai Send Pharmaceutical Technology Co., Ltd.

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View Lastest Price from Azadibenzocyclooctyne-PEG12-N-hydroxysuccinimidyl ester manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: DBCO-PEG12-NHS ester 2093934-94-0
Price: US $0.00/mg
Min. Order: 25mg
Purity: >99.00%
Supply Ability: 100mg
Release date: 2024-03-20

2093934-94-0, Azadibenzocyclooctyne-PEG12-N-hydroxysuccinimidyl esterRelated Search:

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Azadibenzocyclooctyne-PEG12-N-hydroxysuccinimidyl ester

DBCO-NH-PEG12-CH2CH2COONHS ester

DBCO-PEG12-NHS Ester

Poly(oxy-1,2-ethanediyl), α-[2-[[4-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-1,4-dioxobutyl]amino]ethyl]-ω-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropoxy]-

2093934-94-0