Description Referrence
ChemicalBook > CAS DataBase List > 2-Bromothiazole

2-Bromothiazole

Description Referrence
Product Name
2-Bromothiazole
CAS No.
3034-53-5
Chemical Name
2-Bromothiazole
Synonyms
2-BROMO-1,3-THIAZOLE;CL028;TZ-Br;NSC 91532;2-Bromthiazol;2-bromo-thiazol;2-BROMOTHIAZOLE;2-BROMOTHIOAZOLE;Thiazole, 2-bromo-;2-THIAZOLYL BROMIDE
CBNumber
CB1739860
Molecular Formula
C3H2BrNS
Formula Weight
164.02
MOL File
3034-53-5.mol
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2-Bromothiazole Property

Melting point:
171 C
Boiling point:
171 °C (lit.)
Density 
1.82 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.593(lit.)
Flash point:
146 °F
storage temp. 
2-8°C
solubility 
Chloroform, Dichloromethane
pka
0.84±0.10(Predicted)
form 
Liquid
color 
Clear colorless to orange-brown
Specific Gravity
1.836
Water Solubility 
insoluble
BRN 
105724
InChIKey
RXNZFHIEDZEUQM-UHFFFAOYSA-N
CAS DataBase Reference
3034-53-5(CAS DataBase Reference)
NIST Chemistry Reference
Thiazole, 2-bromo-(3034-53-5)
EPA Substance Registry System
Thiazole, 2-bromo- (3034-53-5)
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Safety

Hazard Codes 
Xi,F
Risk Statements 
36/37/38
Safety Statements 
23-24/25-36-26
RIDADR 
1993
WGK Germany 
3
TSCA 
Yes
HazardClass 
IRRITANT, FLAMMABLE
HS Code 
29341000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
160474
Product name
2-Bromothiazole
Purity
98%
Packaging
5g
Price
$54.9
Updated
2024/03/01
Sigma-Aldrich
Product number
160474
Product name
2-Bromothiazole
Purity
98%
Packaging
25g
Price
$102
Updated
2024/03/01
TCI Chemical
Product number
B1280
Product name
2-Bromothiazole
Purity
>98.0%(GC)
Packaging
25g
Price
$79
Updated
2024/03/01
TCI Chemical
Product number
B1280
Product name
2-Bromothiazole
Purity
>98.0%(GC)
Packaging
250g
Price
$464
Updated
2024/03/01
Alfa Aesar
Product number
A14838
Product name
2-Bromothiazole, 99%
Packaging
10g
Price
$59.65
Updated
2024/03/01
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2-Bromothiazole Chemical Properties,Usage,Production

Description

It is usually used as the intermediate or raw material to produce various products in the organic synthesis and pharmaceutical industry, such as 2-acetylthiazole, antibiotics, and anticholinergic drugs. Specifically, this chemical can act as the raw material to produce camalexin through reaction with indolylmagnesium iodide.1 Moreover, this substance has been selected as the reactant to prepare the thiazole Grignard reagents and thiazolyllithium compounds, which can be converted into thiazole-2-carboxylic acid via a halogen-metal exchange reaction.2, 3 In addition, 2-bromothiazole has been used to synthesize N-aryl aminothiazoles, which are found to function as the inhibitors of cyclin-dependent kinases.4 Besides, this compound may be involved in the synthesis of ethynylthiazoles that exhibits a desirable anti-inflammatory activity.5

Referrence

  1. Ayer, W. A.; Craw, P. A.; Ma, Y. T.; Miao, S. C., SYNTHESIS OF CAMALEXIN AND RELATED PHYTOALEXINS. Tetrahedron 1992, 48, 2919-2924.
  2. Kurkjy, R. P.; Brown, E. V., THE PREPARATION OF THIAZOLE GRIGNARD REAGENTS AND THIAZOLYLLITHIUM COMPOUNDS. J. Am. Chem. Soc. 1952, 74, 6260-6262.
  3. Beyerman, H. C.; Berben, P. H.; Bontekoe, J. S., THE SYNTHESIS OF THIAZOLE-2-CARBOXYLIC AND OF THIAZOLE-5-CARBOXYLIC ACID VIA A HALOGEN-METAL EXCHANGE REACTION. Recl. Trav. Chim. Pays-Bas-J. Roy. Neth. Chem. Soc. 1954, 73, 325-332.
  4. Misra, R. N.; Xiao, H. Y.; Williams, D. K.; Kim, K. S.; Lu, S. F.; Keller, K. A.; Mulheron, J. G.; Batorsky, R.; Tokarski, J. S.; Sack, J. S.; Kimball, D.; Lee, F. Y.; Webster, K. R., Synthesis and biological activity of N-aryl-2-aminothiazoles: potent pan inhibitors of cyclin-dependent kinases. Bioorg. Med. Chem. Lett. 2004, 14, 2973-2977.
  5. Geronikaki, A.; Vasilevsky, S.; Hadjipavlou-Litina, D.; Lagunin, A.; Poroikov, B. V., Synthesis and anti-inflammatory activity of ethynylthiazoles. Khim. Geterotsiklicheskikh Soedin. 2006, 769-774.

Chemical Properties

Colourless Liquid

Uses

Aryl halide used to N-arylate 5- and 7-azaindoles.1 Copper-catalyzed cyanation provides 2-cyanothiazole.2

Uses

2-Bromothiazole, is intended used for research purpose only. It is also used as Aryl halide which are used to N-arylate 5- and 7-azaindoles. Copper-catalyzed cyanation provides 2-cyanothiazole

Uses

2-Bromothiazole is a heterocyclic S compound to induce base-pair substitution and having mutagenic activity.

2-Bromothiazole Preparation Products And Raw materials

Raw materials

Phosphoric acid Nitric acid

Preparation Products

THIAZOLE-2-CARBOXYLIC ACID 2-Bromo-5-fomylthiazole 1,3-Thiazole-2-carbonyl chloride Thiazole-5-carboxylic acid 5-Bromothiazole
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View Lastest Price from 2-Bromothiazole manufacturers

JINING XINHE CHEMICAL CO., LTD
Product
2-Bromothiazole 3034-53-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
10ton
Release date
2024-07-22
Shaanxi Dideu Medichem Co. Ltd
Product
2-Bromothiazole 3034-53-5
Price
US $1.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20T
Release date
2024-07-18
Henan Fengda Chemical Co., Ltd
Product
2-Bromothiazole 3034-53-5
Price
US $32.00-1.10/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-22

3034-53-5, 2-BromothiazoleRelated Search:

2,2'-Dithiobis(benzothiazole) Thiazole Benzothiazole 2-Mercaptobenzothiazole Fosthiazate 3-Bromoanisole Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) 2-(2-Aminothiazol-4-yl)glyoxylic acid 2-BROMOCARBAZOLE 2-Bromonaphthalene 2-Bromo-1,3-benzothiazole 2,4-BROMOTHIAZOLE 2-BROMO-4-CHLOROBENZOTHIAZOLE 2-BROMOTHIAZOLE-5-METHANOL ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE 2-BROMOTHIAZOLE-4-METHANOL 2-BROMOTHIAZOLE-4-CARBALDEHYDE 2-BROMOTHIAZOLE-5-CARBOXYLIC ACID

  • 2-THIAZOLYL BROMIDE
  • 2-BROMOTHIOAZOLE
  • 2-BROMOTHIAZOLE
  • 2-BROMO-1,3-THIAZOLE
  • TIMTEC-BB SBB003918
  • 2-Bromothiazole, 98+%
  • Thiazole, 2-bromo-
  • 2-bromo-thiazol
  • 2-BROMOTHIAZOLE 99+%
  • 2-BroMothiazole, 98+% 25ML
  • 2-BroMothiazole, 98+% 5ML
  • NSC 91532
  • 2-BROMOTHIAZOLE FOR SYNTHESIS
  • 2 - broMine thiazole
  • CL028
  • TZ-Br
  • N,N'-bis(2,4-dinitrophenyl)ethane-1,2-diamine
  • 2-Bromthiazol
  • 2-Bromothiazole &gt
  • 2-bromothiazole-4,5-d2
  • 3034-53-5
  • 3430-53-5
  • C3H2BrNS
  • C3H2SNBr
  • -SCHCHNCBr
  • Thiazoles
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Building Blocks
  • alkyl bromide
  • Building Blocks
  • C3 to C7
  • Chemical Synthesis
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Sulfur & Selenium Compounds
  • Thiazoles, Isothiazoles & Benzothiazoles
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Heterocyclic Compounds
  • Thiazoles
  • Halides
  • Heterocycles
  • ThiazolesHeterocyclic Building Blocks
  • Thiazoles, Isothiazoles &Benzothiazoles
  • API intermediates
  • Organohalides
  • Thiazole
  • API