ChemicalBook > CAS DataBase List > 4-Methylthiazole-5-carboxylic acid

4-Methylthiazole-5-carboxylic acid

Product Name
4-Methylthiazole-5-carboxylic acid
CAS No.
20485-41-0
Chemical Name
4-Methylthiazole-5-carboxylic acid
Synonyms
TIMTEC-BB SBB010167;CHEMBRDG-BB 4402151;IFLAB-BB F2124-0222;4-METHYLTHIAZOLE-5-CARBOXYLATE;isoquinolin-5-yl-5-boronic acid;5-Carboxy-4-methyl-1,3-thiazole;4-methyl-5-thiazolecarboxylicaci;4-methyl-5-thiazolecarboxylicacid;4-METHYLTHIAZOLE-5-CARBOXYLIC ACID;4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC
CBNumber
CB1770874
Molecular Formula
C5H5NO2S
Formula Weight
143.16
MOL File
20485-41-0.mol
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4-Methylthiazole-5-carboxylic acid Property

Melting point:
287 °C (dec.) (lit.)
Boiling point:
303.6±22.0 °C(Predicted)
Density 
1.338 (estimate)
refractive index 
1.5480 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO
form 
solid
pka
1.16±0.31(Predicted)
color 
Off-White
InChIKey
ZGWGSEUMABQEMD-UHFFFAOYSA-N
CAS DataBase Reference
20485-41-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
43-36/37/38
Safety Statements 
37/39-26
WGK Germany 
3
RTECS 
XJ3680000
HazardClass 
IRRITANT
HS Code 
29341000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
633666
Product name
4-Methylthiazole-5-carboxylic acid
Purity
97%
Packaging
1g
Price
$68.5
Updated
2023/06/20
Sigma-Aldrich
Product number
633666
Product name
4-Methylthiazole-5-carboxylic acid
Purity
97%
Packaging
10g
Price
$498
Updated
2023/06/20
TCI Chemical
Product number
M2235
Product name
4-Methylthiazole-5-carboxylic Acid
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$80
Updated
2025/07/31
TRC
Product number
M330310
Product name
4-Methylthiazole-5-carboxylic Acid
Packaging
1g
Price
$65
Updated
2021/12/16
Apolloscientific
Product number
OR11384
Product name
4-Methyl-1,3-thiazole-5-carboxylicacid
Purity
95%
Packaging
100g
Price
$215
Updated
2021/12/16
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4-Methylthiazole-5-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

4-Methylthiazole-5-carboxylic acid is used as a reagent to synthesize thiazolylimidazolidinone compounds that act as Stearoyl-CoA desaturase-1 (SCD1) inhibitors. These SCD1 inhibitors are used in the treatment of metabolic diseases. 4-Methylthiazole-5-carboxylic acid is also used as a reagent to synthesize 4-Methyl-5-formylthiazole, an important intermediate in the synthesis of Cefditoren pivoxil (C242700).

Definition

ChEBI: 4-Methyl-thiazole-5-carboxylic acid is an aromatic carboxylic acid and a member of thiazoles.

Synthesis

77287-34-4

609-15-4

20485-41-0

A mechanical stirrer, thermometer and constant pressure dropping funnel were assembled in a 10 L glass reactor and 1 mole of phosphorus pentasulfide (P4S10) and 6 kg of ethylene glycol dimethyl ether were added as solvent under nitrogen protection. Under stirring conditions, 5 moles of formamide was slowly added dropwise and the reaction lasted for 2 hours. Subsequently, 5 moles of ethyl 2-chloroacetoacetate was added dropwise and the reaction was carried out at room temperature for 608 hours. Upon completion of the reaction, the reaction mixture was cooled to 10 °C and the white solid product was collected by filtration. The solid product was dissolved in 4 times its weight in water and the pH was adjusted to 7-8 with 20% sodium hydroxide solution. filtration at 0-5 °C gave ethyl 4-methylthiazole-5-carboxylate as a white solid with 99% purity and 95.8% molar yield.

References

[1] Patent: CN105130924, 2017, B. Location in patent: Paragraph 0021; 0022

4-Methylthiazole-5-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Methylthiazole-5-carboxylic acid manufacturers

Watson Biotechnology Co.,Ltd
Product
4-Methylthiazole-5-carboxylic Acid 20485-41-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20MT
Release date
2024-08-16
Henan Aochuang Chemical Co.,Ltd.
Product
4-Methylthiazole-5-carboxylic acid 20485-41-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-10
Hebei Chuanghai Biotechnology Co,.LTD
Product
4-Methyl-5-Thiazolecarboxylic Acid 20485-41-0
Price
US $9.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-21

20485-41-0, 4-Methylthiazole-5-carboxylic acidRelated Search:

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