2-Bromo-4-methoxypyridine
- Product Name
- 2-Bromo-4-methoxypyridine
- CAS No.
- 89488-29-9
- Chemical Name
- 2-Bromo-4-methoxypyridine
- Synonyms
- bromo-4-methoxypyridine;2-Bromo-4-methoxypyridine;Pyridine,2-bromo-4-methoxy-;2-Bromo-4-methoxypyridine 98%;2-Bromo-4-methoxypyridine ISO 9001：2015 REACH
- CBNumber
- CB1971743
- Molecular Formula
- C6H6BrNO
- Formula Weight
- 188.02
- MOL File
- 89488-29-9.mol
2-Bromo-4-methoxypyridine Property
- Boiling point:
- 120-121 °C(Press: 10 Torr)
- Density
- 1.530±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 2.10±0.10(Predicted)
- form
- solid
- color
- Yellow
Safety
- HS Code
- 2933399990
N-Bromosuccinimide Price
- Product number
- OR61413
- Product name
- 2-Bromo-4-methoxypyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $37
- Updated
- 2021/12/16
- Product number
- 4H56-9-Z8
- Product name
- 2-Bromo-4-methoxypyridine
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- J90714
- Product name
- 2-Bromo-4-methoxypyridine
- Packaging
- 5g
- Price
- $124
- Updated
- 2021/12/16
- Product number
- OR61413
- Product name
- 2-Bromo-4-methoxypyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- FB55589
- Product name
- 2-Bromo-4-methoxypyridine
- Packaging
- 1g
- Price
- $125
- Updated
- 2021/12/16
2-Bromo-4-methoxypyridine Chemical Properties,Usage,Production
Uses
2-Bromo-4-methoxypyridine acts as a reagent for the synthesis of biarylsulfonamide CCR9 inhibitors for inflammatory bowel diseases.
Synthesis
124-41-4
22918-01-0
89488-29-9
The general procedure for the synthesis of 2-bromo-4-methoxypyridine from sodium methanol and 2-bromo-4-chloropyridine was as follows: sodium methanol (0.35 g, 6.48 mmol) was added to a solution of 2-bromo-4-chloropyridine (1.0 g, 5.2 mmol) in dimethyl sulfoxide (DMSO, 10 mL). After the addition was completed, the reaction mixture was stirred at 120 °C for 24 hours. After completion of the reaction, the mixture was cooled to room temperature and extracted with ethyl acetate (EtOAc). The organic layers were combined and dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure. Purification of the residue by preparative high performance liquid chromatography (HPLC) gave 2-bromo-4-methoxypyridine (0.25 g, 25% yield) as a colorless oil. The mass spectrometry (MS) electrospray ionization (ESI) calculated value was 189 for C6H6BrNO [M + H]+ and the measured value was 189.
References
[1] Patent: WO2014/74422, 2014, A1. Location in patent: Paragraph 00162
2-Bromo-4-methoxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Bromo-4-methoxypyridine Suppliers
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
View Lastest Price from 2-Bromo-4-methoxypyridine manufacturers
- Product
- 2-Bromo-4-methoxypyridine 89488-29-9
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 tons
- Release date
- 2024-11-27
- Product
- 2-Bromo-4-methoxypyridine 89488-29-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-27
- Product
- 2-Bromo-4-methoxypyridine 89488-29-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000kgs
- Release date
- 2020-01-02