ChemicalBook > CAS DataBase List > 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one

Product Name
7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
CAS No.
199327-61-2
Chemical Name
7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
Synonyms
Gefitinib-8;quinazolin-4(3H);Gefitinib iMpurity F;Gefitinib Impurity 14;Gefitinib Impurity 17;Gefintinib Impurity 5;Getitinib interMediate;Gefitinib impurities132;Gefitinib impurities135;InterMediate of Gefitinib
CBNumber
CB21477111
Molecular Formula
C16H21N3O4
Formula Weight
319.36
MOL File
199327-61-2.mol
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7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one Property

Melting point:
233-236 °C
Boiling point:
519.5±60.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
7.10±0.10(Predicted)
color 
White to Off-White
CAS DataBase Reference
199327-61-2(CAS DataBase Reference)
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

TRC
Product number
M264670
Product name
7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
Packaging
100mg
Price
$95
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0167548
Product name
7-METHOXY-6-(3-MORPHOLIN-4-YL-PROPOXY)-3H-QUINAZOLIN-4-ONE
Purity
95.00%
Packaging
1G
Price
$918.23
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0167548
Product name
7-METHOXY-6-(3-MORPHOLIN-4-YL-PROPOXY)-3H-QUINAZOLIN-4-ONE
Purity
95.00%
Packaging
10G
Price
$4030.95
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0167548
Product name
7-METHOXY-6-(3-MORPHOLIN-4-YL-PROPOXY)-3H-QUINAZOLIN-4-ONE
Purity
95.00%
Packaging
100G
Price
$12647.25
Updated
2021/12/16
AK Scientific
Product number
X2633
Product name
7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
Packaging
1g
Price
$94
Updated
2021/12/16
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7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one Chemical Properties,Usage,Production

Description

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one is a pharmaceutical intermediate used in the preparation of gefitinib, an orally active selective inhibitor of the epidermal growth factor receptor tyrosine kinase, an enzyme that regulates intracellular signalling pathways that associated with the proliferation and survival of cancer cells.

Chemical Properties

White Solid

Uses

Gefitinib intermediate.

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one Suppliers

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View Lastest Price from 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one manufacturers

Nanjing Fred Technology Co., Ltd
Product
7-methoxy-6-(3-morpholin-4-yl-propoxy）quinazolin-4(3H)-one 199327-61-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%(HPLC)
Supply Ability
2tons
Release date
2023-12-13
Zibo Hangyu Biotechnology Development Co., Ltd
Product
7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one 199327-61-2
Price
US $110.00-560.00/g
Min. Order
5g
Purity
99%
Supply Ability
50
Release date
2024-07-12
Hebei shuoxi biotechnology co. LTD
Product
7-methoxy-6-(3-morpholin-4-ylpropoxy)-1H-quinazolin-4-one 199327-61-2
Price
US $50.00/g
Min. Order
10g
Purity
99.8%
Supply Ability
10tons
Release date
2020-04-17

199327-61-2, 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-oneRelated Search:

Methoxydiethylborane m-Anisyl alcohol p-Anisidine POLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATE 4-Methoxybenzoic acid p-Anisaldehyde Anisole Methoxyacetic acid (Trifluoromethoxy)benzene Gefitinib-d6 Gefitinib 6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate 4-(3-Chloropropyl)morpholine Gefitinib Impurity 11 6,7-Dimethoxy-3,4-dihydroquinazoline-4-one

  • 7-Methoxy-6-(3-Morpholin-4-ylpropoxy) Quinazolin- 4-(3H)-One Gefitinib HCL InterMediates G5
  • Getitinib interMediate
  • Gefitinib iMpurity F
  • 7-METHOXY-6-(3-MORPHOLINOPROPOXY)QUINAZOLIN-4(3H)-ONE
  • 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
  • 7-Methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
  • 7-Methoxy-6-[3-(4-morpholinyl)propoxy]-4(3H)-quinazolinone
  • Gefitinib Impurity 14
  • 7-methoxy-6-(3-morpholin-4-ylpropoxy)-1H-quinazolin-4-one
  • 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quainazolin-4(3H)-one
  • 6-(3-morpholinopropoxy)-7-methoxyquinazolin-4(3H)-one
  • 7-Methoxy-6-(3-morpholinopropoxy)
  • quinazolin-4(3H)
  • 7-Methoxy-6-(3-morpholin-4-yl-propoxy)-3H-quinazolin-4-one
  • 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin
  • 7-Methoxy-6-[3-(Morpholin-4-yl)propoxy]-3,4-dihydroquinazolin-4-one
  • Gefitinib Impurity 17
  • InterMediate of Gefitinib
  • 7-Methoxy-6-(3-Morpholin-4-yl-propoxy) -4-(3H)-quinazolinone
  • Gefintinib Impurity 5
  • Gefitinib-8
  • 4(3H)-Quinazolinone, 7-methoxy-6-[3-(4-morpholinyl)propoxy]-
  • 7-METHOXY-6-(MORPHOLIN-4-YL PROPY L)QUINAZOLIN-4-(3H)-ONE
  • Gefitinib impurities132
  • Gefitinib impurities135
  • TIANFU-CHEM - 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
  • 7-Methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4(1H)-one
  • 7-methoxy-6- (3-morpholine-4-ylpropyloxy) quinazoline-4 (3H) - one
  • 7-Methoxy-6-(3-morpholinopropoxy)quizolin-4(3H)-one
  • 7-methoxy-6-(4-morpholinobutyl) quinazolin-4(3H)-one
  • [containing < 0.5 % formamide (EC No 200-842-0)]
  • [containing ≥ 0.5 % formamide (EC No 200-842-0) ]
  • 199327-61-2
  • 31936
  • Gefitinib INTERMEDIATES
  • Heterocycles
  • Intermediates
  • Intermediates & Fine Chemicals
  • Pharmaceuticals