BESTATIN HYDROCHLORIDE

Product Name: BESTATIN HYDROCHLORIDE
CAS No.: 65391-42-6
Chemical Name: BESTATIN HYDROCHLORIDE
Synonyms: BESTATIN HCL;Bestatin.HCI;Ubenimex HCl;Ubenimex-d7 HCl;BESTATIN HYDROCHLORIDE;Ubenimex hydrochloride;HYDROCHLORIDE,Ubenimex;Bestatin research grade;BESTATIN HYDROCHLORIDE USP/EP/BP;Bestatin-d7 HCl (Ubenimex-d7 HCl)
CBNumber: CB2172341
Molecular Formula: C16H25ClN2O4
Formula Weight: 344.83
MOL File: 65391-42-6.mol

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BESTATIN HYDROCHLORIDE Property

Melting point:: 216-218 °C
storage temp.: 2-8°C
solubility: H₂O: 25 mg/mL, clear, colorless
form: White to off-white powder.
color: White
Water Solubility: Soluble in water (4 mg/ml, warm), DMSO (>25 mg/ml), methanol, acetic acid, dimethyl formamide, and 100% ethanol.
BRN: 4628066
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO, distilled water, or ethanol may be stored at -20° for up to 1 month.
InChIKey: XGDFITZJGKUSDK-UDYGKFQRSA-N
CAS DataBase Reference: 65391-42-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 22-24/25-36-26
WGK Germany: 3
F: 3-10
HS Code: 29242995

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B8385
Product name: Bestatin hydrochloride
Purity: ≥98% (HPLC)
Packaging: 1mg
Price: $76.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: B8385
Product name: Bestatin hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $164
Updated: 2024/03/01

Sigma-Aldrich

Product number: 10874515001
Product name: Bestatin
Purity: [(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-L-leucinehydrochloride
Packaging: 10mg
Price: $244
Updated: 2022/05/15

TCI Chemical

Product number: B4000
Product name: N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Hydrochloride
Purity: >97.0%(HPLC)
Packaging: 25mg
Price: $194
Updated: 2024/03/01

Alfa Aesar

Product number: J60384
Product name: Bestatin hydrochloride, 98%
Packaging: 5mg
Price: $87.65
Updated: 2024/03/01

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BESTATIN HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Bestatin HCl (65391-42-6) inhibits leucine aminopeptidase and aminopeptidases B and N. Inhibits leukotriene A4 hydrolase. Displays immunostimulant activity via activation of macrophages and T lymphocytes. Displays antitumor activity.

Uses

Bestatin Hydrochloride is an inhibitor of aminopeptidases, LAP3, and leukotriene A4 hydrolase. It is the salt form of Bestatin (B319500).

Uses

competitive aminopeptidase B inhibitor

Uses

Bestatin is an inhibitor of amino peptidases and a potent, irreversible inhibitor of LTA4 hydrolase. It inhibits the amino peptidase activity of LTA4 hydrolase with a Ki value of 201 nM. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation. It does not inhibit carboxypeptidases.

Uses

Bestatin has been used as a protease inhibitor for the purification of his-tagged Tau protein.

Definition

ChEBI: Bestatin (hydrochloride) is a peptide.

General Description

Chemical structure: amino acid derivatives

Biochem/physiol Actions

A metalloprotease inhibitor selective for aminopeptidase. Bestatin is a competitive and specific inhibitor of leucine aminopeptidase, aminopeptidase B, and triamino peptidase. It inhibits aminopeptidase B at 60 nM (using arginine-β-naphthylamide as substrate) and leucine aminopeptidase at 20 nM (leucine-β-naphthylamide as substrate). It showed no inhibition of aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, or themolysin. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation.

in vivo

in a mouse dorsal air sac assay, oral administration of bestatin (100-200 mg/kg/day) showed a significant inhibitory activity against the melanoma cell-induced angiogenesis. bestatin also inhibited the tube-like formation of human umbilical vein endothelial cells (huvecs). furthermore, after the orthotopic implantation of b16-bl6 melanoma cells into mice, bestatin administration (50-100 mg/kg/day, i.p) reduced the number of vessels oriented towards the established primary tumor mass on the dorsal side of mice [1].

References

1) Orning et al. (1991), Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes; J. Biol. Chem., 266 1375 2) Wang et al. (2010), The effect of different species aminopeptidase N structure on the activity screening of aminopeptidase N inhibitor; Biol. Pharm. Bull., 33 1658

BESTATIN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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BESTATIN HYDROCHLORIDE Suppliers

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View Lastest Price from BESTATIN HYDROCHLORIDE manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: BESTATIN HYDROCHLORIDE 65391-42-6
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-05-28

Zhuozhou Wenxi import and Export Co., Ltd

Product: Bestatin hydrochloride 65391-42-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Bestatin hydrochloride 65391-42-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

65391-42-6, BESTATIN HYDROCHLORIDERelated Search:

CARBOXYPEPTIDASE A CARBOXYPEPTIDASE B CARBOXYPEPTIDASE B Trypsin Chymotrypsin N-CARBOBENZOXY-DL-LEUCINE 1,3-Diamino-2-propanol Bestatin N-(2-HYDROXYETHYL)LACTAMIDE BESTATIN HYDROCHLORIDE (R)-(-)-4-PHENYL-2-BUTANOL D(+)-Phenylalaninol H-BETA-ALA-NH2 HCL 1,3-Dimethylbutylamine L-Leucine hydrochloride DIETHANOLAMINE HYDROCHLORIDE Betaine hydrochloride N-(3-AMINOPROPYL)GLYCINE DIHYDROCHLORIDE

N-[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL]-L-LEUCINE HYDROCHLORIDE

N-(3R-AMINO-2S-HYDROXY-1-OXO-4-PHENYLBUTYL)-L-LEUCINE, MONOHYDROCHLORIDE

[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-L-LEUCINE HCL

[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-L-LEUCINE HYDROCHLORIDE

(AMINO-2-HYDROXY-4-PHENYLBUTYRYL)-L-LEUCINE HYDROCHLORIDE

BESTATIN HCL

BESTATIN HYDROCHLORIDE

N-(2S,3R-3-AMINO-2-HYDROXY-4-PHENYLBUTY- RYL)-L-LEUCINE HCL

Bestatin.HCI

N-(3-Amino-2-hydroxy-1-oxo-4-phenylbutyl)-L-leucine monohydrochloride

(S)-2-((2S,3R)-3-aMino-2-hydroxy-4-phenylbutanaMido)-4-Methylpentanoic acid hydrochloride

L-Leucine,N-[(2S,3R)-3-aMino-2-hydroxy-1-oxo-4-phenylbutyl]-, hydrochloride (1:1)

Ubenimex Hydrochloride [for Biochemical Research]

Ubenimex hydrochloride

Bestatin research grade

Bestatin-d7 HCl (Ubenimex-d7 HCl)

Ubenimex-d7 HCl

HYDROCHLORIDE,Ubenimex

Bestatin hydrochloride, ≥98% (HPLC)

N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Hydrochloride &gt

BESTATIN HYDROCHLORIDE USP/EP/BP

Ubenimex-d7 HClQ: What is Ubenimex-d7 HCl Q: What is the CAS Number of Ubenimex-d7 HCl

(4S,5R)-5-amino-4-hydroxy-2-(2-methylpropyl)-3-oxo-6-phenyl-D-norleucine hydrochloride

N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-L-leucine hydrochloride

(S)-2-((2S,3R)-3-Amino-2-hydroxy-4-phenylbutanamido)-4-methylpentanoic acid hydrochloride[Ubenimex Hydrochloride

Ubenimex HCl，Bestatin hydrochloride

Ubenimex HCl

65391-42-6

C16H24N2O4ClH

C16HH24N2O4xHCL

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Bestatin

inhibitor

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