ChemicalBook > CAS DataBase List > 2-Furoic acid

2-Furoic acid

Product Name
2-Furoic acid
CAS No.
88-14-2
Chemical Name
2-Furoic acid
Synonyms
Furan-2-carboxylic acid;2-Furancarboxylic acid;FURAN-2-CARBONYL CHLORIDE;Furoica;FUROYL CHLORIDE;2-furancarboxylate;2-Furancarbosylicacid;2-FURANCARBONYL CHLORIDE;2-Furoic;Furoic aci
CBNumber
CB2189363
Molecular Formula
C5H4O3
Formula Weight
112.08
MOL File
88-14-2.mol
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2-Furoic acid Property

Melting point:
−2 °C(lit.)
Boiling point:
173-174 °C(lit.)
Density 
1.324 g/mL at 25 °C(lit.)
vapor pressure 
13.732Pa at 25℃
refractive index 
n20/D 1.531(lit.)
Flash point:
185 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
37g/l
form 
Fine Crystalline Powder
pka
3.16(at 25℃)
color 
Off-white to beige
Odor
odorless
Odor Type
odorless
Water Solubility 
36 g/L (20 ºC)
Merck 
14,4307
BRN 
110149
InChIKey
SMNDYUVBFMFKNZ-UHFFFAOYSA-N
LogP
0.628 at 25℃
CAS DataBase Reference
88-14-2(CAS DataBase Reference)
NIST Chemistry Reference
2-Furancarboxylic acid(88-14-2)
EPA Substance Registry System
2-Furancarboxylic acid (88-14-2)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
34-36/37/38
Safety Statements 
26-36/37/39-45-36-37/39
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
RTECS 
LV1763000
F 
10-19-21
TSCA 
Yes
HS Code 
29321900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F20505
Product name
2-Furoic acid
Purity
98%
Packaging
5g
Price
$36.2
Updated
2024/03/01
Sigma-Aldrich
Product number
57552
Product name
2-Furoic acid
Purity
analytical standard
Packaging
100mg
Price
$82.2
Updated
2024/03/01
TCI Chemical
Product number
F0081
Product name
2-Furancarboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$19
Updated
2024/03/01
TCI Chemical
Product number
F0081
Product name
2-Furancarboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
500g
Price
$104
Updated
2024/03/01
Alfa Aesar
Product number
A11454
Product name
2-Furoic acid, 98%
Packaging
100g
Price
$37.6
Updated
2024/03/01
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2-Furoic acid Chemical Properties,Usage,Production

Description

2-Furoic acid is an organic compound, consisting of a furan ring and a carboxylic acid side-group. Along with other furans, its name is derived from the Latin word furfur, meaning bran, from which these compounds were first produced. The salts and esters of furoic acids are known as furoates. 2-Furoic acid is most widely encountered in food products as a preservative and a flavouring agent, where it imparts a sweet, earthy flavour.

Chemical Properties

white to light yellow crystal powder. 1g is dissolved in 26ml cold water or 4ml boiling water, easily soluble in ethanol and ether. Sublimation at 130-140°C (6.65-8kPa).

Uses

2-Furoic acid is an heterocyclic carboxylic acid that is widely used in food products as a preservative and flavouring agent. It is also used in the synthesis of methylfuran, furoamide and furoic acid esters and salts. In the plastics industry, it can be used as plasticizer, thermosetting resin, etc. substitute for chloropicrin in disinfecting grain elevators.

Preparation

2-furoic acid can be synthesized by the oxidation of furfural. The reaction was carried out at 45°C with vigorous stirring. The reactant is filtered to recover the catalyst copper oxide, the filtrate is acidified with 50% sulfuric acid to pH 3-2.5, suction filtered, washed with water, and dried to obtain 2-furoic acid.

Application

2-Furoic acid (FA) is a preservative, acting as a bactericide and fungicide. Some of the applications of 2-furoic acid include:
Synthesis of a single-molecule magnet, Mn11Gd2 based high-nuclearity heterometallic complex.
Synthesis of orally active antidiabetic vanadyl complex, bis(α-furancarboxylato)oxovanadium(IV).
As a ligand in the synthesis of luminescent 4f-3d heterometallic one-dimensional coordination polymers.
Synthesis of biocompatible multifunctional dextran furoate nanospheres.
FA is often used as a starting material for the production of furoate esters.
FA and its derivatives are also used in the production of nylons principally applied in biomedical researches.

Definition

ChEBI: 2-furoic acid is a furoic acid having the carboxylic acid group located at position 2. It has a role as an inhibitor, a human xenobiotic metabolite, a Saccharomyces cerevisiae metabolite, a plant metabolite and a bacterial xenobiotic metabolite. It is a conjugate acid of a 2-furoate.

Biological Functions

2-Furoic acid was shown to effectively lower serum cholesterol and serum triglyceride levels significantly in rats with an elevation of HDL cholesterol level at 20 mg/kg/day orally. 2-furoic acid appears to interfere directly with the activity of intracellular enzymes rather than affecting high affinity-mediated lipoprotein membrane receptors. In vivo, treatment with 2-furoic acid led to a reduction in the liver and small intestine ATP-dependent citrate lyase, acetyl CoA synthetase, acyl CoA cholesterol acyl transferase, sn-glycerol 3-phosphate acyl transferase, phosphatidylate phosphohydrolase, and heparin induced lipoprotein lipase activities. 2-Furoic acid reduced biliary cholesterol levels, but the agent increased bile salts, which are lithogenic. Acute toxicity studies in mice suggest that the agent has some hepatic toxicity effects. The LD50 was relatively low at 250 mg/kg IP in mice[1].

Hazard

Strong irritant to eyes and skin.

Flammability and Explosibility

Not classified

Solubility in organics

Soluble in alcohol, miscible with oils.

Purification Methods

Crystallise the acid from hot water (charcoal), dry it at 120o for 2hours, then recrystallise it from CHCl3, and again dry it at 120o for 2hours. For use as a standard in volumetric analysis, good quality commercial acid should be crystallised from CHCl3 and dried as above or sublimed at 130-140o/50-60mm or less. [Beilstein 18 I 438, 18 II 265, 18 III/IV 3914, 18/6 V 102.]

References

[1] Iris H. Hall. “Hypolipidemic Effects of 2-Furoic Acid in Sprague-Dawley Rats.” Archiv der Pharmazie 326 1 (1993): 15–23.

2-Furoic acid Preparation Products And Raw materials

Raw materials

Uraldehyde Cupric oxide Sodium chlorate hypochlorous acid

Preparation Products

2-BROMO-5-NITROFURAN 6-METHOXY-1-NAPHTHOIC ACID METHYL 5-(CHLOROMETHYL)-2-FUROATE 6-Hydroxy-1-naphthoic acid 2-Amino-5-chlorobenzophenone Terazosin Methyl 2-furoate Ethyl 2-furoate 1-(2-Furoyl)piperazine (Z)-alpha-(methoxyimino)furan-2-acetic acid 5-Bromofuroic acid L-Lysine hydrochloride 5-Chloro-2-(methylamino)benzophenone Ethyl maltol Monosodium glutamate Ascorbic Acid D-ARABINONIC ACID L-(+)Sodium glutamate Lactic acid 2-Furoyl chloride 3-Methylfuran Mucobromic acid Furan
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View Lastest Price from 2-Furoic acid manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
2-Furoic acid 88-14-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 mt
Release date
2024-11-04
Hebei Weibang Biotechnology Co., Ltd
Product
2-Furoic acid 88-14-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-30
Qingdao RENAS Polymer Material Co., Ltd.
Product
2-Furoic acid 88-14-2
Price
US $0.00/kg
Min. Order
20kg
Purity
99%
Supply Ability
20 tons
Release date
2024-09-29

88-14-2, 2-Furoic acidRelated Search:

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  • Ceftiofur Impurity 2
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  • 2-FURANCARBOXYLIC ACID CHLORIDE
  • AKOS BBS-00003923
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