NVP-BEP800
- Product Name
- NVP-BEP800
- CAS No.
- 847559-80-2
- Chemical Name
- NVP-BEP800
- Synonyms
- CS-1973;VER82576;VER-82576;NVP-BEP800;NVP-BEP800 BEP-800;NVP-BEP800 USP/EP/BP;VER-82576 (NVP-BEP800);VER-82576;NVP BEP800;VER82576;2-Amino-4-(2,4-dichloro-5-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-ethylthieno[2,3-d]pyrimidine-6-;2-Amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide
- CBNumber
- CB22506238
- Molecular Formula
- C21H23Cl2N5O2S
- Formula Weight
- 480.41
- MOL File
- 847559-80-2.mol
NVP-BEP800 Property
- Density
- 1.396
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥16 mg/mL in EtOH with gentle warming; ≥24.7 mg/mL in DMSO with gentle warming and ultrasonic
- form
- Powder
- pka
- 13.25±0.46(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 18383
- Product name
- NVP-BEP800
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 18383
- Product name
- NVP-BEP800
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $78
- Updated
- 2024/03/01
- Product number
- 18383
- Product name
- NVP-BEP800
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 18383
- Product name
- NVP-BEP800
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $281
- Updated
- 2024/03/01
- Product number
- 461049
- Product name
- NVP-BEP 800
- Packaging
- 1mg
- Price
- $333
- Updated
- 2021/12/16
NVP-BEP800 Chemical Properties,Usage,Production
Uses
NVP-BEP 800 is a Hsp90 inhibitor which ehibits anti-proliferative effects against cancer cell lines with high expression level of Hsp90.
Biological Activity
nvp-bep800 is a fully synthetic, orally bioavailable inhibitor of hsp90 with ic50 value of 58nm [1].nvp-bep800 binds to the n-terminal atp-binding pocket of hsp90. in a competitive binding fluorescence polarization assay, nvp-bep800 inhibits hsp90β with ic50 value of 58nm. and to other 20 protein kinases, nvp-bep800 shows a ic50 of >10μm. in bt-474 cells and a375 cells, nvp-bep800 causes the hsp90-p23 dissociation and client protein degradation (erbb2) as well as the reduction of client protein phosphorylation (phospho-akt). degradation of these oncogenic client proteins results in tumor cell growth arrest and death. nvp-bep800 inhibits proliferation of tumor cells with an average gi50 of 245nm. and in 46 primary human tumors including small cell lung, mammary cancer and melanoma, the mean ic50 is 750nm. additionally, treatment of nvp-bep800 induces apoptosis in human breast cancer cell lines. the antitumor efficacy of nvp-bep800 is also observed with a dose of 15 or 30 mg/kg/d in a375 xenograft-bearing mice as well as in bt-474 breast cancer xenografts [1].
target
Hsp90β
References
[1] massey aj, schoepfer j, brough pa, brueggen j, chène p, drysdale mj, pfaar u, radimerski t, ruetz s, schweitzer a, wood m, garcia-echeverria c, jensen mr. preclinical antitumor activity of the orally available heat shock protein 90 inhibitor nvp-bep800. mol cancer ther. 2010 apr;9(4):906-19.
NVP-BEP800 Preparation Products And Raw materials
Raw materials
Preparation Products
NVP-BEP800 Suppliers
- Tel
- Country
- China Hong Kong
- ProdList
- 878
- Advantage
- 55
View Lastest Price from NVP-BEP800 manufacturers
- Product
- NVP-BEP800 847559-80-2
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- customise
- Release date
- 2018-08-09