NVP-BEP800

Product Name: NVP-BEP800
CAS No.: 847559-80-2
Chemical Name: NVP-BEP800
Synonyms: CS-1973;VER82576;VER-82576;NVP-BEP800;NVP-BEP800 BEP-800;NVP-BEP800 USP/EP/BP;VER-82576 (NVP-BEP800);VER-82576;NVP BEP800;VER82576;2-Amino-4-(2,4-dichloro-5-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-ethylthieno[2,3-d]pyrimidine-6-;2-Amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide
CBNumber: CB22506238
Molecular Formula: C21H23Cl2N5O2S
Formula Weight: 480.41
MOL File: 847559-80-2.mol

More

Less

NVP-BEP800 Property

Density: 1.396
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥16 mg/mL in EtOH with gentle warming; ≥24.7 mg/mL in DMSO with gentle warming and ultrasonic
form: Powder
pka: 13.25±0.46(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 18383
Product name: NVP-BEP800
Purity: ≥98%
Packaging: 500μg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18383
Product name: NVP-BEP800
Purity: ≥98%
Packaging: 1mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 18383
Product name: NVP-BEP800
Purity: ≥98%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 18383
Product name: NVP-BEP800
Purity: ≥98%
Packaging: 10mg
Price: $281
Updated: 2024/03/01

Usbiological

Product number: 461049
Product name: NVP-BEP 800
Packaging: 1mg
Price: $333
Updated: 2021/12/16

More

Less

NVP-BEP800 Chemical Properties,Usage,Production

Uses

NVP-BEP 800 is a Hsp90 inhibitor which ehibits anti-proliferative effects against cancer cell lines with high expression level of Hsp90.

Biological Activity

nvp-bep800 is a fully synthetic, orally bioavailable inhibitor of hsp90 with ic50 value of 58nm [1].nvp-bep800 binds to the n-terminal atp-binding pocket of hsp90. in a competitive binding fluorescence polarization assay, nvp-bep800 inhibits hsp90β with ic50 value of 58nm. and to other 20 protein kinases, nvp-bep800 shows a ic50 of >10μm. in bt-474 cells and a375 cells, nvp-bep800 causes the hsp90-p23 dissociation and client protein degradation (erbb2) as well as the reduction of client protein phosphorylation (phospho-akt). degradation of these oncogenic client proteins results in tumor cell growth arrest and death. nvp-bep800 inhibits proliferation of tumor cells with an average gi50 of 245nm. and in 46 primary human tumors including small cell lung, mammary cancer and melanoma, the mean ic50 is 750nm. additionally, treatment of nvp-bep800 induces apoptosis in human breast cancer cell lines. the antitumor efficacy of nvp-bep800 is also observed with a dose of 15 or 30 mg/kg/d in a375 xenograft-bearing mice as well as in bt-474 breast cancer xenografts [1].

target

Hsp90β

References

[1] massey aj, schoepfer j, brough pa, brueggen j, chène p, drysdale mj, pfaar u, radimerski t, ruetz s, schweitzer a, wood m, garcia-echeverria c, jensen mr. preclinical antitumor activity of the orally available heat shock protein 90 inhibitor nvp-bep800. mol cancer ther. 2010 apr;9(4):906-19.

NVP-BEP800 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

NVP-BEP800 Suppliers

China 73 China Hong Kong 1 United States 18 Global 92

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

ApexBio Technology LLC

Tel: +1-832-696-8203
Fax: +1-832-641-3177
Email: info@apexbt.com
Country: United States
ProdList: 477
Advantage: 60

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

More

Less

View Lastest Price from NVP-BEP800 manufacturers

Career Henan Chemical Co

Product: NVP-BEP800 847559-80-2
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: customise
Release date: 2018-08-09

847559-80-2, NVP-BEP800Related Search:

Butyl stearate Bromothymol Blue NVP-BAW2881 BEZ235 (Tosylate) NVP-AAM077 Infigratinib NVP-LDE225 NVP-TNKS656 TAE226 (NVP-TAE226) NVP-ADW742 NVP-CGM097 NVP-TAE684 NVP-BEZ 235 UMI-77 PU-H71 BI-97C1 Talazoparib (BMN 673) NVP-HSP990(HSP990)

NVP-BEP800

2-amino-4-(2,4-dichloro-5-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide

NVP-BEP800;2-AMINO-4-(2,4-DICHLORO-5-(2-(PYRROLIDIN-1-YL)ETHOXY)PHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE

2-Amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide

VER82576

VER-82576

2-Amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide NVP-BEP 800

NVP-BEP 800 2-Amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide

2-Amino-4-(2,4-dichloro-5-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-ethylthieno[2,3-d]pyrimidine-6-

CS-1973

VER-82576 (NVP-BEP800)

VER-82576;NVP BEP800;VER82576

NVP-BEP800 USP/EP/BP

NVP-BEP800 BEP-800

Thieno[2,3-d]pyrimidine-6-carboxamide, 2-amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethyl-

847559-80-2

C21H23Cl2N5O2S

Inhibitor

apis

Inhibitors