DBCO-PEG4-SE
- Product Name
- DBCO-PEG4-SE
- CAS No.
- 1427004-19-0
- Chemical Name
- DBCO-PEG4-SE
- Synonyms
- DBCO-PEG4-SE;DBCO-PEG4-NHS;DBCO-PEG4-SPA;DBCO-PEG4-NHS easer;DBCO-PEG4-NHS ester;DBCO-CONH-PEG4-NHS ester;DBCO-PEG4-succinimidyl ester;Dibenzocyclooctyne-PEG4-N-hydroxysuccinimidyl ester;inhibit,Inhibitor,DBCO PEG4 NHS ester,DBCOPEG4NHS ester,DBCO-PEG-4-NHS ester,PROTAC Linkers;2,5-Dioxo-1-pyrrolidinyl 20-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-17,20-dioxo-4,7,10,13-tetraoxa-16-azaeicosanoate
- CBNumber
- CB22984375
- Molecular Formula
- C34H39N3O10
- Formula Weight
- 649.69
- MOL File
- 1427004-19-0.mol
DBCO-PEG4-SE Property
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO, DCM, DMF
- pka
- 15.14±0.46(Predicted)
- form
- gel or oil
- color
- Colourless to yellow
- InChI
- InChI=1S/C34H39N3O10/c38-30(11-12-31(39)36-25-28-7-2-1-5-26(28)9-10-27-6-3-4-8-29(27)36)35-16-18-44-20-22-46-24-23-45-21-19-43-17-15-34(42)47-37-32(40)13-14-33(37)41/h1-8H,11-25H2,(H,35,38)
- InChIKey
- RRCXYKNJTKJNTD-UHFFFAOYSA-N
- SMILES
- C(ON1C(=O)CCC1=O)(=O)CCOCCOCCOCCOCCNC(=O)CCC(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)=O
Safety
- WGK Germany
- 3
- HS Code
- 2942000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 764019
- Product name
- Dibenzocyclooctyne-PEG4-N-hydroxysuccinimidyl ester
- Purity
- 95%
- Packaging
- 1MG
- Price
- $37
- Updated
- 2023/06/20
- Product number
- 764019
- Product name
- Dibenzocyclooctyne-PEG4-N-hydroxysuccinimidyl ester
- Purity
- 95%
- Packaging
- 5MG
- Price
- $118
- Updated
- 2023/06/20
- Product number
- 764019
- Product name
- Dibenzocyclooctyne-PEG4-N-hydroxysuccinimidyl ester
- Purity
- 95%
- Packaging
- 50MG
- Price
- $510
- Updated
- 2023/06/20
- Product number
- D195020
- Product name
- DBCO-PEG4-NHSEster
- Packaging
- 1mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 35051
- Product name
- DBCO-PEG4-NHSester,95%
- Purity
- 95%
- Packaging
- 5MG
- Price
- $56
- Updated
- 2021/12/16
DBCO-PEG4-SE Chemical Properties,Usage,Production
Description
DBCO-PEG4-NHS Ester is a click chemistry PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions.
Uses
Succinimidyl ester (NHS, amine reactive) functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into amine containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free click chemistry cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.
Applications Include:
- Protein-peptide conjugates
- Antibody-enzyme or antibody-drug conjugates
- Protein or peptide-oligonucleotide conjugates
- Surface modification
DBCO-PEG4-SE Preparation Products And Raw materials
Raw materials
Preparation Products
DBCO-PEG4-SE Suppliers
- Tel
- --
- Fax
- --
- sales@apolloscientific.co.uk
- Country
- United Kingdom
- ProdList
- 6084
- Advantage
- 88
View Lastest Price from DBCO-PEG4-SE manufacturers
- Product
- DBCO-PEG4-NHS ester 1427004-19-0
- Price
- US $0.00/mg
- Min. Order
- 50mg
- Purity
- >99.00%
- Supply Ability
- 250
- Release date
- 2024-03-20