Synthesis
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3,5-Difluoroaniline

Synthesis
Product Name
3,5-Difluoroaniline
CAS No.
372-39-4
Chemical Name
3,5-Difluoroaniline
Synonyms
3,5-DIFLUOROBENZENAMINE;NSC 81289;5-Difluoroaniline;3,5-Difluoranilin;3,5-DIFLUOROANILINE;3, 5-2 fluoro aniline;3,5-Difluoroaniline>3,5-Difluoroaniline,98%;3,5-Difluorophenylamine;3,5-Difluoroaniline 98%
CBNumber
CB2339018
Molecular Formula
C6H5F2N
Formula Weight
129.11
MOL File
372-39-4.mol
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3,5-Difluoroaniline Property

Melting point:
37-41 °C (lit.)
Boiling point:
80°C 20mm
Density 
1,295 g/cm3
refractive index 
1,512-1,514
Flash point:
167 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
Water Solubility 
Insoluble in water
form 
Low Melting Solid
pka
2.57±0.10(Predicted)
color 
White to yellow
BRN 
2802286
InChI
InChI=1S/C6H5F2N/c7-4-1-5(8)3-6(9)2-4/h1-3H,9H2
InChIKey
KQOIBXZRCYFZSO-UHFFFAOYSA-N
SMILES
C1(N)=CC(F)=CC(F)=C1
CAS DataBase Reference
372-39-4(CAS DataBase Reference)
EPA Substance Registry System
3,5-Difluoroaniline (372-39-4)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
28-36/37/39-26-36
RIDADR 
UN 1325 4.1/PG 2
WGK Germany 
3
F 
8-10-23
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29214200
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
D2665
Product name
3,5-Difluoroaniline
Purity
>98.0%(GC)
Packaging
5g
Price
$40
Updated
2025/07/31
TCI Chemical
Product number
D2665
Product name
3,5-Difluoroaniline
Purity
>98.0%(GC)
Packaging
25g
Price
$196
Updated
2025/07/31
TRC
Product number
D442325
Product name
3,5-Difluoroaniline
Packaging
5g
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD64333
Product name
3,5-Difluoroaniline
Packaging
500g
Price
$75
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK410839
Product name
3,5-Difluoroaniline
Purity
98%
Packaging
5g
Price
$76
Updated
2021/12/16
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3,5-Difluoroaniline Chemical Properties,Usage,Production

Synthesis

Work on halogenated benzenes has also demonstrated the versatility of this technique and a variety of fluoro-chloro and -bromo benzenes may be de-brominated and de-chlorinated. Two patents describe removal of chlorine from 2,6-dichloro-3,5- difluoronitrobenzene giving 3,5-difluoroaniline.

Chemical Properties

white to yellowish low melting solid

Uses

3,5-Difluoroaniline has been used in the preparation of 3,5-difluorodimethylaniline.

General Description

In vitro nephrotoxic effects of 3,5-difluoroaniline has been investigated in renal cortical slices obtained from the kidneys of untreated, male Fischer 344 rats.

References

[1] Patent: CN108314624, 2018, A. Location in patent: Paragraph 0054; 0055; 0056; 0057

3,5-Difluoroaniline Preparation Products And Raw materials

Raw materials

Preparation Products

2-AMINO-4,6-DIFLUOROBENZOIC ACID 4-AMINO-2,6-DIFLUORO-BENZALDEHYDE
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3,5-Difluoroaniline Suppliers

Americas 1 Belgium 4 China 354 Europe 3 France 3 Germany 9 India 18 Indonesia 1 Italy 1 Japan 4 Jordan 1 Slovakia 1 South Africa 1 Switzerland 2 Ukraine 2 United Kingdom 20 United States 46 Global 471
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
ecochem international chemical broker
Tel
--
Fax
--
Email
export@ecochem.dk
Country
Europe
ProdList
6371
Advantage
66
kemikalieimport
Tel
--
Fax
--
Email
Sales@kemikalieimport.dk
Country
Europe
ProdList
6685
Advantage
47
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View Lastest Price from 3,5-Difluoroaniline manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
3,5-Difluoroaniline 372-39-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-31
Hebei Yanxi Chemical Co., Ltd.
Product
3,5-Difluoroaniline 372-39-4
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-09-13
Shaanxi Dideu New Materials Co. Ltd
Product
3,5-Difluoroaniline 372-39-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-02-27

372-39-4, 3,5-DifluoroanilineRelated Search:

Diphenylamine 4-(Trifluoromethoxy)aniline 4-Fluoroaniline N,N-Dimethylaniline 2-Fluoroaniline 3-Fluoroaniline Sodium diphenylamine-4-sulfonate 2-Aminobenzotrifluoride N,N-Dimethyl-1,4-phenylenediamine 2,4-Difluoroaniline97% 2,3,4,5-Tetrafluoronitrobenzene 3,5-Difluoronitrobenzene 4-AMINO-2,3,5,6-TETRAFLUOROBENZOIC ACID 4-AMINO-2,3,5,6-TETRAFLUOROBENZAMIDE 2,6-Difluoroaniline 2,5-Difluoroaniline 4,4'-Diaminooctafluorobiphenyl 2,3,5,6-TETRAFLUOROPHENYLHYDRAZINE

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  • C2 to C6
  • Amines
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