Description References
ChemicalBook > CAS DataBase List > Vanillic acid

Vanillic acid

Description References
Product Name
Vanillic acid
CAS No.
121-34-6
Chemical Name
Vanillic acid
Synonyms
VA;4-HYDROXY-3-METHOXYBENZOIC ACID;vanillic;3-Methoxy-4-Hydroxybenzoic acid;Benzoic acid, 4-hydroxy-3-methoxy-;Vanillate;Magnolioside;Vanilic acid;Vanilloid;Vallinic acid
CBNumber
CB2449434
Molecular Formula
C8H8O4
Formula Weight
168.15
MOL File
121-34-6.mol
More
Less

Vanillic acid Property

Melting point:
208-210 °C(lit.)
Boiling point:
257.07°C (rough estimate)
Density 
1.3037 (rough estimate)
refractive index 
1.5090 (estimate)
FEMA 
3988 | 4-HYDROXY-3-METHOXYBENZOIC ACID
storage temp. 
Store below +30°C.
solubility 
Acetonitrile (Slightly), Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly）
pka
pKa 4.53(H2O t = 25 c = 0.016–0.001) (Uncertain)
form 
Liquid
color 
Clear colorless to brown, may darken during storage
Odor
at 100.00 %. dairy milky custard creamy powdery vanilla bean
Odor Type
creamy
Water Solubility 
Soluble in water, alcohol and ether.
Merck 
14,9931
JECFA Number
959
BRN 
2208364
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
WKOLLVMJNQIZCI-UHFFFAOYSA-N
LogP
1.30
CAS DataBase Reference
121-34-6(CAS DataBase Reference)
NIST Chemistry Reference
Benzoic acid, 4-hydroxy-3-methoxy-(121-34-6)
EPA Substance Registry System
Vanillic acid (121-34-6)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
37/39-26-36
WGK Germany 
1
RTECS 
YW5300000
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29189090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W398802
Product name
Vanillic acid
Purity
≥97%, FG
Packaging
1kg
Price
$559
Updated
2024/03/01
Sigma-Aldrich
Product number
W398802
Product name
Vanillic acid
Purity
≥97%, FG
Packaging
10Kg
Price
$3940
Updated
2024/03/01
Sigma-Aldrich
Product number
94770
Product name
Vanillic acid
Purity
purum, ≥97.0% (HPLC)
Packaging
10g
Price
$26
Updated
2024/03/01
Sigma-Aldrich
Product number
8.41025
Product name
Vanillic acid
Purity
for synthesis
Packaging
50g
Price
$108
Updated
2024/03/01
Sigma-Aldrich
Product number
68654
Product name
Vanillic acid
Purity
certified reference material, TraceCERT
Packaging
50mg
Price
$128
Updated
2024/03/01
More
Less

Vanillic acid Chemical Properties,Usage,Production

Description

Vanillic acid is a dihydroxybenzoic acid that can be used as a flavoring agent. As an oxidized form of vanillin, it is the intermediate product during the two-step bioconversion process from ferulic acid to vanillin. It exists in high amount in the root of Angelica sinenisis, which is a plant used in traditional Chinese medicine. It also exists in acal oil, argan oil as well as wine and vinegar. It can be used in the synthesis of the analeptic drug etamivan, modecainide, brovanexine, vanitiolide, and vanyldisulfamide. It can be manufactured through the oxidation of vanillin to the carboxylic acid.

References

https://en.wikipedia.org/wiki/Vanillic_acid
https://pubchem.ncbi.nlm.nih.gov/compound/Vanillic_acid#section=Top

Chemical Properties

4-Hydroxy-3-methoxybenzoic acid has a vanilla-like odor and taste.

Chemical Properties

white odourless crystals or powder

Occurrence

Reported found in guava, grape, brandy, rum, whiskey, sherry, red and white wines, Scotch and Canadian whiskey, pork (fried), cocoa, peanuts (raw), mushrooms, guava fruit, mangos (fresh), wort, vanilla and black chokeberries.

Uses

Vanillic acid is used as a flavoring agent in food. It acts as an intermediate in the production of vanillin from ferulic acid. Further, it is used in wine and vinegar.

Uses

Vanillin, a compound widely used in foods, beverages, cosmetics and drugs, has been reported to exhibit multifunctional effects such as antimutagenic, antiangiogenetic, anti-colitis, anti-sickling, an d antianalgesic effects. However, results of studies on the antioxidant activity of vanillin are not consistent.

Uses

A flavoring agent.

Definition

ChEBI: A monohydroxybenzoic acid that is 4-hydroxybenzoic acid substituted by a methoxy group at position 3.

Preparation

Prepared by bioconversion of ferulic acid by means of a vanillate-negative mutant of Pseudomonas fluorescens strain BS13. Also prepared by whole-cell bioconversion of vanillin to vanillic acid by Streptomyces viridosporus

Aroma threshold values

Aroma at 5.0%: weak vanilla, creamy, milky.

Taste threshold values

Taste characteristics at 100 ppm: weak sweet resinous vanilla, creamy with a smooth sweetness and body, slightly chocolate-like with a spicy vanitrop nuance

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 429, 1946 DOI: 10.1021/ja01207a025
Organic Syntheses, Coll. Vol. 4, p. 972, 1963

General Description

Vanillic acid is one of the key aromatic volatile compounds of vanilla beans.

Biochem/physiol Actions

Taste at 100 ppm

Vanillic acid Preparation Products And Raw materials

Raw materials

Valeric acid Phosphorus trichloride 1-Pentanol butene Thionyl chloride

Preparation Products

More
Less

Vanillic acid Suppliers

Belgium 1 Canada 1 China 488 Europe 3 France 5 Germany 8 India 35 Japan 4 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 9 United States 58 USA 1 Global 619
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
Frinton Laboratories Inc.,
Tel
--
Fax
--
Country
United States
ProdList
355
Advantage
58
Leonid Chemicals Private Limited
Tel
--
Fax
--
Email
careers@leonidchemicals.com
Country
United States
ProdList
1700
Advantage
43
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Pyrazine Specialties, Inc.
Tel
--
Fax
--
Country
United States
ProdList
1265
Advantage
30
WholeChem, LLC
Tel
--
Fax
--
Email
info@wholechem.com
Country
United States
ProdList
814
Advantage
58
M&U International LLC
Tel
--
Fax
--
Email
sales@mu-intel.com
Country
United States
ProdList
2011
Advantage
58
Prodasynth
Tel
--
Fax
--
Email
info@prodasynth.com
Country
United States
ProdList
423
Advantage
58
Penta International Corporation
Tel
--
Fax
--
Email
lisaa@pentamfg.com
Country
United States
ProdList
5042
Advantage
58
Lluch Essence S.L.
Tel
--
Fax
--
Email
web@lluche.com
Country
United States
ProdList
2352
Advantage
58
Beijing Lys Chemicals Co, LTD.
Tel
--
Fax
--
Email
jiayanyong@lyschem.com
Country
United States
ProdList
710
Advantage
58
Qingdao Free Trade Zone United International Co Ltd
Tel
--
Fax
--
Email
info@unitedint.com
Country
United States
ProdList
604
Advantage
58
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Wilshire Chemical Company Inc.
Tel
--
Fax
--
Email
WilshrChem@AOL.COM
Country
United States
ProdList
3498
Advantage
58
Anvia Chemicals, LLC
Tel
--
Fax
--
Email
sales@anviachem.com
Country
United States
ProdList
3933
Advantage
0
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
ChemService Inc.
Tel
--
Fax
--
Country
United States
ProdList
6379
Advantage
68
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
Penta Manufacturing Company
Tel
--
Fax
--
Email
sales@pentamfg.com
Country
United States
ProdList
5076
Advantage
65
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
City Chemical LLC
Tel
--
Fax
--
Email
sales@citychemical.com
Country
United States
ProdList
6708
Advantage
72
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
SRS Aromatics Ltd
Tel
--
Fax
--
Email
info@srsaromatics.co.uk
Country
United States
ProdList
2315
Advantage
46
Chemiplus Corporation
Tel
--
Fax
--
Email
okazaki@chemiplus.com
Country
United States
ProdList
3198
Advantage
38
Medical Isotopes
Tel
--
Fax
--
Email
stohler@medicalisotopes.com
Country
United States
ProdList
6181
Advantage
68
Advanced Synthesis Technologies
Tel
--
Fax
--
Email
sales@advancedsynthesis.com
Country
United States
ProdList
4775
Advantage
61
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
Fontarome Chemical, Inc.
Tel
--
Fax
--
Email
cindy_sonsthagen@fontaromechemical.com
Country
United States
ProdList
268
Advantage
38
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
Sinova Inc.
Tel
--
Fax
--
Email
sales@sinovainc.com
Country
United States
ProdList
4009
Advantage
58
ChromaDex
Tel
--
Fax
--
Email
sales@chromadex.com
Country
United States
ProdList
2501
Advantage
76
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
More
Less

View Lastest Price from Vanillic acid manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Vanillic Acid 121-34-6
Price
US $200.00-95.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-04-24
Shandong Deshang Chemical Co., Ltd.
Product
Vanillic acid 121-34-6
Price
US $6.00-3.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 tons
Release date
2024-08-15
Hebei Chuanghai Biotechnology Co,.LTD
Product
Vanillic acid 121-34-6
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-21

121-34-6, Vanillic acid Related Search:

Nonivamide CHLOROPHOSPHONAZO III Salicylic acid 2,3,4-Trihydroxybenzoic acid Citric acid Folic acid 3-Hydroxybenzoic acid Stearic acid Homovanillic acid 2'-Hydroxy-3-phenylpropiophenone 2,6-Dimethoxybenzoic acid 3,4-Dimethoxybenzoic acid Ethyl 2-(Chlorosulfonyl)acetate Hyaluronic acid 4-Methoxybenzoic acid 4-Hydroxybenzoic acid VANILLIC ACID ETHYL ESTER,VANILLIC ACID ETHYL ESTER 97+% Methylparaben

  • PROTOCATECHUIC ACID 3-METHYL ETHER
  • TIMTEC-BB SBB008280
  • RARECHEM AL BO 0061
  • VANILLIC ACID
  • VENILLIC ACID
  • 4-HYDROXY-3-METHOXYBENZOIC ACID
  • AKOS BBS-00003785
  • FEMA 3988
  • 3-Methoxy-4-Hydroxybenzoic acid
  • 3-methoxy-4-hydroxybenzoicacid
  • vanillic
  • VANILLIC ACID 97+%
  • VanillinAcid
  • VanillicAcid99%
  • Vanillic Acid (4-Hydroxy-3-methoxybenzoic acid)
  • Vanillic Acid 99%
  • 4-Hydroxy-3-methoxybenzoic acid, 98.5+%
  • Benzoic acid, 4-hydroxy-3-methoxy-
  • VANILLIC ACID(RG)
  • 3-METHOXY-4-HYDROXYBENZOICACID(VANILLICACID)
  • Vanillinsure
  • Benzoicacid,4-hydroxy-3-m
  • 4-HYDROXY-3-METHOXYBENZOIC ACID 99+%
  • 4-Vanillic acid
  • VANILLIC ACID, TECH. GRADE
  • 2-Methoxy-4-carboxyphenol
  • Magnolioside
  • Vanilic acid
  • 4-Hydroxy-3-Methoxybenzoic Acid 3-Methoxy-4-Hydroxybenzoic Acid
  • all-trans-Retinol ,3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
  • Vanillate
  • Vallinic acid
  • 4-Hydroxy-3-methoxybenzoic acid (vanillic acid)
  • 4-hydroxy-3-methoxy-benzoicaci
  • 4-hydroxy-m-anisicaci
  • Acide vanillique
  • acidevanillique
  • m-Anisic acid, 4-hydroxy-
  • Protocatechuic acid, 3-methyl ester
  • protocatechuicacid,3-methylester
  • p-Vanillic acid
  • p-vanillicacid
  • VA
  • Vanillic acid puruM, >=97.0% (HPLC)
  • Vanilloid
  • 4-Hydroxy-3-Methoxybenzoic acid, 98.5+% 25GR
  • Vanillic acid Vetec(TM) reagent grade, 97%
  • Vanillic Acid, Reagent
  • Vanillic acid, 99%, for synthesis
  • VANILLIC ACID FOR SYNTHESIS 50 G
  • Opicapone Impurity 10
  • Opicapone Impurity 9
  • para-vanillic acid
  • 4-Hydroxy-3-Methoxy benzoic acid (Vanillic acid 98%)
  • 2-Hydroxy-4-Methoxy benzoic acid -98%
  • Factory Price Sell 4-Hydroxy-3-Methoxybenzoic Acid Powder Vanillic Acid?121-34-6
  • Vanillic Acid D3
  • Vanillic Acid extrapure, 99%