3-Amino-2-bromopyridine
- Product Name
- 3-Amino-2-bromopyridine
- CAS No.
- 39856-58-1
- Chemical Name
- 3-Amino-2-bromopyridine
- Synonyms
- TIMTEC-BB SBB005539;3-Amino-2-bromopyrid;2-BROMO-PYRIDINEAMINE;2-bromopyridin-3-amine;2-Bromo-3-pyridinamine;2-BROMO-3-PYRIDINEAMINE;2-BROMOPYRIDINE-3-AMINE;2-BROMO-3-AMINOPYRIDINE;3-AMINO-2-BROMOPYRIDINE;3-Pyridinamine, 2-bromo-
- CBNumber
- CB2730581
- Molecular Formula
- C5H5BrN2
- Formula Weight
- 173.01
- MOL File
- 39856-58-1.mol
3-Amino-2-bromopyridine Property
- Melting point:
- 76-80 °C
- Boiling point:
- 292.5±20.0 °C(Predicted)
- Density
- 1.710±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Crystalline Powder
- pka
- 1.72±0.10(Predicted)
- color
- Beige to dark brown
- Water Solubility
- Slightly soluble in water.
- BRN
- 109830
- InChIKey
- HKDVVTLISGIPFE-UHFFFAOYSA-N
- CAS DataBase Reference
- 39856-58-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-37/38-41-36/37/38
- Safety Statements
- 26-36/39-37/39
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- HazardClass
- IRRITANT
- PackingGroup
- III
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 661228
- Product name
- 3-Amino-2-bromopyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $33.47
- Updated
- 2025/07/31
- Product number
- A1898
- Product name
- 3-Amino-2-bromopyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $33
- Updated
- 2025/07/31
- Product number
- A1898
- Product name
- 3-Amino-2-bromopyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $102
- Updated
- 2025/07/31
- Product number
- A602123
- Product name
- 3-Amino-2-bromopyridine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- A602123
- Product name
- 3-Amino-2-bromopyridine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
3-Amino-2-bromopyridine Chemical Properties,Usage,Production
Chemical Properties
Light yellow Cryst
Uses
Used in a palladium-catalyzed synthesis of indole systems containing fused medium- and large-ring heterocycles. pyrrole derivatives ahs been prepared using 3-Amino-2-bromopyridine. Used in P-C coupling reaction.
Synthesis
19755-53-4
39856-58-1
Preparation of Example S-1: 2-Bromo-3-nitropyridine (3 g, 15 mmol) was dissolved in a solvent mixture of tetrahydrofuran (15 mL) and water (5 mL), followed by the addition of iron powder (1 g, 18 mmol) and ammonium chloride (2 g, 37 mmol). The reaction mixture was stirred at 60°C to 70°C for 5 hours. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad and the filtrate was washed with brine and extracted with ethyl acetate. The organic layers were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=1:4) to afford 2-bromo-3-aminopyridine (2.6 g, 15 mmol, quantitative yield).1H-NMR (DMSO-d6) δ (ppm): 5.47 (2H, brs), 7.07-7.09 (2H, m), 7.54 (1H, dd, J=). 2.0,3.6Hz).
References
[1] Patent: EP1782811, 2007, A1. Location in patent: Page/Page column 63
[2] Patent: EP1669348, 2006, A1. Location in patent: Page/Page column 71
[3] Bulletin de la Societe Chimique de France, 1992, # 1, p. 79 - 84
[4] Journal of the Chemical Society, 1952, p. 2042,2044
[5] Tetrahedron, 2002, vol. 58, # 17, p. 3323 - 3328
3-Amino-2-bromopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Amino-2-bromopyridine manufacturers
- Product
- 3-Amino-2-bromopyridine 39856-58-1
- Price
- US $21.00/KG
- Min. Order
- 1KG
- Purity
- 99.0% min
- Supply Ability
- 100 tons
- Release date
- 2021-04-16
- Product
- 3-Amino-2-bromopyridine 39856-58-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-04-30
- Product
- 3-Amino-2-bromopyridine 39856-58-1
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-24