ChemicalBook > CAS DataBase List > D-Proline

D-Proline

Product Name
D-Proline
CAS No.
344-25-2
Chemical Name
D-Proline
Synonyms
Proline;H-D-PRO-OH;D-PRO;D-Pro-OH;(R)-PYRROLIDINE-2-CARBOXYLIC ACID;(2R)-Pyrrolidine-2-carboxylic acid;D-PYRROLIDINE-2-CARBOXYLIC ACID;D-PyrroL;D-PROLINE;D(+)-PROLINE
CBNumber
CB2754303
Molecular Formula
C5H9NO2
Formula Weight
115.13
MOL File
344-25-2.mol
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D-Proline Property

Melting point:
223 °C (dec.) (lit.)
alpha 
84.75 º (c=4, H2O)
Boiling point:
215.41°C (rough estimate)
Density 
1.36
refractive index 
85 ° (C=4, H2O)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Methanol (Slightly), Water (Sparingly)
form 
Powder
pka
1.952(at 25℃)
color 
White to yellow to pale brown
optical activity
[α]22/D +85.0°, c = 4 in H2O
Water Solubility 
soluble >1000 g/L (20 ºC)
Sensitive 
Hygroscopic
BRN 
80811
InChIKey
ONIBWKKTOPOVIA-SCSAIBSYSA-N
LogP
-0.060 (est)
CAS DataBase Reference
344-25-2(CAS DataBase Reference)
EPA Substance Registry System
D-Proline (344-25-2)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22-36/37/38
Safety Statements 
22-24/25-36/37/39-26
WGK Germany 
3
F 
3-10
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29339990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
858919
Product name
D-Proline
Purity
ReagentPlus , ≥99%
Packaging
500mg
Price
$46.7
Updated
2024/03/01
Sigma-Aldrich
Product number
858919
Product name
D-Proline
Purity
ReagentPlus , ≥99%
Packaging
5g
Price
$114
Updated
2024/03/01
TCI Chemical
Product number
P0994
Product name
D-Proline
Purity
>98.0%(T)
Packaging
5g
Price
$76
Updated
2024/03/01
TCI Chemical
Product number
P0994
Product name
D-Proline
Purity
>98.0%(T)
Packaging
25g
Price
$242
Updated
2024/03/01
Alfa Aesar
Product number
A10682
Product name
D-Proline, 99%
Packaging
1g
Price
$42.65
Updated
2024/03/01
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D-Proline Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Occurrence

D-proline is an isomer of the naturally occurring amino acid, L-Proline. D-amino acids have been found in relatively high abundance in human plasma and saliva. These amino acids may be of bacterial origin, but there is also evidence that they are endogenously produced through amino acid racemase activity.

Uses

Used in the synthesis of (R)-(+)-N-Boc-Pipecolic Acid, (S)-(-)-Coniine, (S)-(+)-Pelletierine, (+)-.beta.-Conhydrine, and (S)-(-)-Ropivacaine and formal synthesis of (-)-Lasubine II and (+)-Cermizine C.

Uses

Labelled D-Proline Lasubine II and (+)-Cermizine C.

Uses

proline is a skin-conditioning agent. An amino acid found in the collagen molecule.

Definition

ChEBI: D-proline is the D-enantiomer of proline. It has a role as a mouse metabolite. It is a D-alpha-amino acid and a proline. It is a conjugate base of a D-prolinium. It is a conjugate acid of a D-prolinate. It is an enantiomer of a L-proline. It is a tautomer of a D-proline zwitterion.

Synthesis Reference(s)

Journal of the American Chemical Society, 71, p. 2818, 1949 DOI: 10.1021/ja01176a065
Tetrahedron Letters, 28, p. 6469, 1987 DOI: 10.1016/S0040-4039(00)96890-4

D-Proline Preparation Products And Raw materials

Raw materials

L-Proline

Preparation Products

N-Boc-D-proline (1R,2R)-N-BOC-1-AMINO-2-PHENYLCYCLOPROPANECARBOXYLIC ACID
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D-Proline Suppliers

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View Lastest Price from D-Proline manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
D-Proline 344-25-2
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-12-06
Hubei Lidu New Material Technology Co., Ltd
Product
D-Proline 344-25-2
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20t
Release date
2024-12-11
WUHAN FORTUNA CHEMICAL CO., LTD
Product
D-Proline 344-25-2
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98.5%-101%
Supply Ability
500kg
Release date
2021-06-02

344-25-2, D-ProlineRelated Search:

D-Tartaric acid D-Alanine D-Proline trans-4-Hydroxy-D-proline N-Benzyloxycarbonyl-D-proline cis-4-Hydroxy-D-proline Fmoc-D-proline BOC-D-PRO-OSU AC-D-PRO-OH (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid Z-D-PYR-OH Methyl pyrrolidine-2-carboxylate hydrochloride D-Pyroglutamic acid Ethyl D-(-)-pyroglutamate Oxaceprol trans-4-Cyclohexyl-L-proline 1-(4-HYDROXY-PHENYL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID,1-(4-HYDROXY-PHENYL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID H-D-PRO-OTBU

  • D-Pro-OH
  • D-Proline≥ 99% (Assay)
  • D-Proline,99%e.e.
  • (R)-(+)-PROLINE
  • (R)-PYRROLIDINE-2-CARBOXYLIC ACID
  • D-2-PYRROLIDINECARBOXYLIC ACID
  • D-PYRROLIDINE-2-CARBOXYLIC ACID
  • D(+)-PROLINE
  • D-PROLINE
  • D-PRO
  • H-D-PYRD(2)-OH
  • H-D-PRO-OH
  • D-Proline,99%
  • H-D-PRO-OH UPS24 (IN BULK QUANTITY)
  • D-(+)-Prolin
  • Proline
  • Glycinate Fumasuan Salt
  • (2R)-Pyrrolidine-2-carboxylic acid
  • D-PROLINE, 99+% (98% EE/GLC)
  • D-PyrroL
  • idine-2-carboxyL
  • Captopril Impurity 32
  • D-(+)-PROLINE ((R)-(+)-PROLINE)
  • D-PROLINE extrapure
  • D-Proline-d3
  • D-Proline, (2R)-2-Carboxypyrrolidine
  • D-Proline ReagentPlus(R), >=99%
  • D-Proline Vetec(TM) reagent grade, 98%
  • D-Proline&gt
  • D-Proline，98%
  • D-Proline USP/EP/BP
  • dextro-(+)-proline
  • D-Proline CAS No. 344-25-2
  • D-Proline extrapure CHR, 99%
  • D-Proline (9CI, ACI)
  • Captopril Impurity 38
  • (2R)-pyrrolidin-1-ium-2-carboxylate
  • 344-25-2
  • 24344-25-2
  • 145-85-3
  • 344-25-5
  • C5H9NO2
  • CARBOXYLIC ACID
  • Amino Acid Derivatives
  • Proline
  • Peptide Synthesis
  • Specialty Synthesis
  • Amino Acids and Derivatives
  • Proline [Pro, P]
  • Amino Acids and Derivatives
  • alpha-Amino Acids
  • Amino Acids
  • Biochemistry
  • Amino Acids & Derivatives
  • Heterocycles
  • Isotope Labelled Compounds
  • 206-452-7
  • Amino ACIDS SERIES