ZK 756326
- Product Name
- ZK 756326
- CAS No.
- 874911-96-3
- Chemical Name
- ZK 756326
- Synonyms
- CS-2219;ZK 756326;ZK756326 2HCl;2-(2-(4-(3-Phenoxybenzyl)piperazin-1-yl)ethoxy)ethan-1-ol;2-[2-[4-[(3-Phenoxyphenyl)methyl]-1-piperazinyl]ethoxy]ethanol;2-[2-[4-[(3-Phenoxyphenyl)methyl]piperazin-1-yl]-ethoxy]-ethanol;Ethanol, 2-[2-[4-[(3-phenoxyphenyl)methyl]-1-piperazinyl]ethoxy]-;2-(2-(4-(3-phenoxybenzyl)piperazin-1-yl)ethoxy)ethanoldihydrochloride;2-[2-[4-[(3-phenoxyphenyl)methyl]-1-piperazinyl]ethoxy]ethanoldihydrochloride
- CBNumber
- CB2785596
- Molecular Formula
- C21H28N2O3
- Formula Weight
- 356.46
- MOL File
- 874911-96-3.mol
ZK 756326 Property
- storage temp.
- Desiccate at RT
- form
- White solid.
- Water Solubility
- Soluble to 100 mM in water
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 2565
- Product name
- ZK756326
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $170
- Updated
- 2021/12/16
- Product number
- 2565
- Product name
- ZK756326
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $710
- Updated
- 2021/12/16
- Product number
- P301395
- Product name
- 2-[2-[4-[(3-Phenoxyphenyl)methyl]-1-piperazinyl]ethoxy]-ethanol
- Packaging
- 0.5mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 257171
- Product name
- ZK 756326
- Packaging
- 10mg
- Price
- $438
- Updated
- 2021/12/16
- Product number
- B7109
- Product name
- ZK756326
- Packaging
- 5mg
- Price
- $125
- Updated
- 2021/12/16
ZK 756326 Chemical Properties,Usage,Production
Uses
2-?[2-?[4-?[(3-?Phenoxyphenyl)?methyl]?-?1-?piperazinyl]?ethoxy]?-ethanol is a nonpeptide CCR8 chemokine receptor agonist that inhibits the binding of the CCR8 ligand I-309 (CCL1), with an IC(50) value of 1.8 muM (1). It is a useful compound to investigate the physiological role of CCR8 in HIV infection.
Biological Activity
Selective, non-peptide CCR8 chemokine receptor agonist (IC 50 values are 1.8 and 2.6 μ M for human and mouse receptors respectively). Displays no activity at CCR4, CXCR3, CXCR4 and CCR5 and shows > 28-fold selectivity over 26 other GPCRs (less selective at α 2A and 5-HT receptors). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion.
ZK 756326 Preparation Products And Raw materials
Raw materials
Preparation Products
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