PROTAC CDK2/9 Degrader-1

Product Name: PROTAC CDK2/9 Degrader-1
CAS No.: 2408641-24-5
Chemical Name: PROTAC CDK2/9 Degrader-1
Synonyms: PROTAC CDK2;PROTAC CDK2/9 Degrader-1;4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-(4-((2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)amino)-4-oxobutanoyl)piperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide;N-{4-[(4-{3-[(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethyl)carbamoyl]propanoyl}piperazin-1-yl)methyl]phenyl}-4-({7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)-1H-pyrazole-3-carboxamide
CBNumber: CB28054502
Molecular Formula: C40H41N13O7
Formula Weight: 815.84
MOL File: Mol file

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PROTAC CDK2/9 Degrader-1 Property

Density: 1.534±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 130 mg/mL (159.34 mM; Need ultrasonic)
form: Solid
pka: 10.74±0.40(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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PROTAC CDK2/9 Degrader-1 Chemical Properties,Usage,Production

Biological Activity

PROTAC CDK2/9 Degrader-1 (Compound F3) is a potent dual degrader for CDK2 (DC50=62 nM) and CDK9 (DC50=33 nM). PROTAC CDK2/9 Degrader-1 suppresses prostate cancer PC-3 cell proliferation (IC50=0.12 μM) by effectively blocking the cell cycle in S and G2/M phases. PROTAC CDK2/9 Degrader-1 is a PROTAC by tethering CDK inhibitor with CRBN ligand[1]. PROTAC CDK2/9 Degrader-1 (0.25-3 μM; 48 hours) induces cell cycle blockage at the G2/M phase[1].PROTAC CDK2/9 Degrader-1 (500 nM; 2-24 hours) down-regulates the Mcl-1 protein level in PC-3 cells[1].PROTAC CDK2/9 Degrader-1 effectively degrades CDK2/9 in cell lines MCF-7, HCT-116 and 22Rv1, which all have high CDK2/9 expression[1].PROTAC CDK2/9 Degrader-1 inhibits both CDK2 and CDK9, with IC50 as 7.42 nM and 14.50 nM, respectively[1].

References

[1]. Zhou F, et al. Development of selective mono or dual PROTAC degrader probe of CDK isoforms. Eur J Med Chem. 2019 Dec 6;187:111952.

PROTAC CDK2/9 Degrader-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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PROTAC CDK2/9 Degrader-1 Suppliers

China 6 United States 1 Global 7

Jilin Province Woda Biotechnology Co., Ltd.

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cjbscvictory

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ShenZhen Trendseen Biological Technology Co.,Ltd.

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Email: vip@med-life.cn
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2408641-24-5, PROTAC CDK2/9 Degrader-1Related Search:

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PROTAC CDK2/9 Degrader-1

PROTAC CDK2

4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-(4-((2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)amino)-4-oxobutanoyl)piperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide

N-{4-[(4-{3-[(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethyl)carbamoyl]propanoyl}piperazin-1-yl)methyl]phenyl}-4-({7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)-1H-pyrazole-3-carboxamide

2408641-24-5