ChemicalBook > CAS DataBase List > methyl 6-chloropyrimidine-4-carboxylate

methyl 6-chloropyrimidine-4-carboxylate

Product Name
methyl 6-chloropyrimidine-4-carboxylate
CAS No.
6627-22-1
Chemical Name
methyl 6-chloropyrimidine-4-carboxylate
Synonyms
NSC 58346;Methyl 6-chloro-4-pyrimidinecarboxylate;methyl 6-chloropyrimidine-4-carboxylate;4-Chloro-6-pyrimidinecarboxylate methyl ester;6-Chloro-4-Pyrimidinecarboxylic Acid Methyl Ester;4-PyriMidinecarboxylic acid, 6-chloro-, Methyl ester;methyl 6-chloropyrimidine-4-carboxylate ISO 9001：2015 REACH;6-Chloropyrimidin-4-carboxylic acid methyl ester (7CI 9CI aci);6-chloro-4-Pyrimidinecarboxylic acid methyl ester (7CI 9CI ACI);4-Pyrimidinecarboxylic acid, 6-chloro-, methyl ester (7CI, 9CI, ACI)
CBNumber
CB31458452
Molecular Formula
C6H5ClN2O2
Formula Weight
172.57
MOL File
6627-22-1.mol
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methyl 6-chloropyrimidine-4-carboxylate Property

Boiling point:
271℃
Density 
1.372
Flash point:
118℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-2.89±0.17(Predicted)
Appearance
Light yellow to brown Solid
InChI
InChI=1S/C6H5ClN2O2/c1-11-6(10)4-2-5(7)9-3-8-4/h2-3H,1H3
InChIKey
IAEUEOUJKNGPMO-UHFFFAOYSA-N
SMILES
C1=NC(Cl)=CC(C(OC)=O)=N1
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
M295625
Product name
Methyl6-chloropyrimidine-4-carboxylate
Packaging
25mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
7126AJ
Product name
Methyl6-chloropyrimidine-4-carboxylate
Packaging
250mg
Price
$28
Updated
2021/12/16
SynQuest Laboratories
Product number
4H21-5-0L
Product name
Methyl 6-chloropyrimidine-4-carboxylate
Packaging
1g
Price
$184
Updated
2021/12/16
SynQuest Laboratories
Product number
4H21-5-0L
Product name
Methyl 6-chloropyrimidine-4-carboxylate
Packaging
5G
Price
$472
Updated
2021/12/16
ChemBridge Corporation
Product number
BB-4066002
Product name
methyl6-chloro-4-pyrimidinecarboxylate
Purity
95%
Packaging
200μmol
Price
$63
Updated
2021/12/16
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methyl 6-chloropyrimidine-4-carboxylate Chemical Properties,Usage,Production

Synthesis

7399-93-1

6627-22-1

General procedure for the synthesis of methyl 6-chloropyrimidine-4-carboxylate from methyl 6-oxo-3,6-dihydropyrimidine-4-carboxylate: [0778] To a 2000 mL four-necked round-bottomed flask was added methyl 6-hydroxypyrimidine-4-carboxylate (115 g, 746.16 mmol, 1.00 equiv.), acetonitrile (1,200 mL), and phosphorous triclopyr (340 g, 2.22 mol, 3.00 equiv). The reaction mixture was stirred at 80 °C overnight. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under vacuum. Subsequently, the reaction mixture was diluted with 1000 mL of ethyl acetate and quenched with 1000 mL of ice water. The aqueous phase was extracted with 3 x 500 mL of ethyl acetate. The organic layers were combined, washed sequentially with 1000 mL of water and 1000 mL of saturated saline, dried over anhydrous sodium sulfate, and concentrated under vacuum. The residue was purified by silica gel column chromatography using ethyl acetate/petroleum ether (1:4) as eluent to give 76 g (59% yield) of methyl 6-chloropyrimidine-4-carboxylate as a white solid.LCMS [M + H]+ 173.

References

[1] Patent: WO2016/128529, 2016, A1. Location in patent: Paragraph 0774; 0777; 0778
[2] Patent: WO2018/15410, 2018, A1. Location in patent: Paragraph 0228; 0232-0233

methyl 6-chloropyrimidine-4-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from methyl 6-chloropyrimidine-4-carboxylate manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
methyl 6-chloropyrimidine-4-carboxylate 6627-22-1
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-12
Career Henan Chemical Co
Product
methyl 6-chloropyrimidine-4-carboxylate 6627-22-1
Price
US $1.00/KG
Min. Order
1KG
Purity
85.0-99.8%
Supply Ability
20tons
Release date
2020-01-08

6627-22-1, methyl 6-chloropyrimidine-4-carboxylateRelated Search:

Methyl 6-methylnicotinate Methyl 6-HydroxypyriMidine-4-carboxylate 2-Chloro-6-pyrazinecarboxylic acid methyl ester 6-METHYLPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER Methyl 6-bromo-2-naphthoate 6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER methyl 6-methylpyridine-2-carboxylate METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE 6-CHLORO-2-PICOLINIC ACID METHYL ESTER Methyl 6-chloronicotinate Methyl 6-bromohexanoate Methyl 6-bromoisoquinoline-1-carboxylate METHYL 6-FORMYLNICOTINATE Methyl 6-bromonicotinate METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE 6-BROMO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER Uracil PYRIMIDINE-4-CARBOXYLIC ACID METHYL ESTER

  • 4-PyriMidinecarboxylic acid, 6-chloro-, Methyl ester
  • methyl 6-chloropyrimidine-4-carboxylate
  • Methyl 6-chloro-4-pyrimidinecarboxylate
  • NSC 58346
  • methyl 6-chloropyrimidine-4-carboxylate ISO 9001：2015 REACH
  • 4-Pyrimidinecarboxylic acid, 6-chloro-, methyl ester (7CI, 9CI, ACI)
  • 6-chloro-4-Pyrimidinecarboxylic acid methyl ester (7CI 9CI ACI)
  • 6-Chloropyrimidin-4-carboxylic acid methyl ester (7CI 9CI aci)
  • 4-Chloro-6-pyrimidinecarboxylate methyl ester
  • 6-Chloro-4-Pyrimidinecarboxylic Acid Methyl Ester
  • 6627-22-1