Polyinosinic acid-polycytidylic acid

Product Name: Polyinosinic acid-polycytidylic acid
CAS No.: 24939-03-5
Chemical Name: Polyinosinic acid-polycytidylic acid
Synonyms: polyi:c;polyi-c;Poly-Na;poly(i+c);Poly I:Cr;nsc-120949;polycpolyi;poly(ri:rc);Polyinosinic;polyri:polyrc
CBNumber: CB3181814
Molecular Formula: C19H27N7O16P2
Formula Weight: 671.41
MOL File: 24939-03-5.mol

More

Less

Polyinosinic acid-polycytidylic acid Property

storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Water (Slightly)
form: Solid
color: White to Off-White
Water Solubility: Soluble to 3 mg/ml in water
Stability:: Hygroscopic
InChIKey: ACEVNMQDUCOKHT-WOQDZEJINA-N
SMILES: O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=CC(N)=NC1=O)O.O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=NC2C(NC=NC1=2)=O)O |&1:1,2,3,11,22,23,24,32,r|

More

Less

Safety

WGK Germany: 3
RTECS: TR0175000

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H402Harmful to aquatic life

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Tocris

Product number: 4287
Product name: Poly(I:C)
Packaging: 10
Price: $98
Updated: 2021/12/16

Tocris

Product number: 4287
Product name: Poly(I:C)
Packaging: 50
Price: $410
Updated: 2021/12/16

TRC

Product number: P688075
Product name: Poly(I:C)(~90%)
Packaging: 50mg
Price: $65
Updated: 2021/12/16

TRC

Product number: P688075
Product name: Poly(I:C)(~90%)
Packaging: 250mg
Price: $85
Updated: 2021/12/16

Biosynth Carbosynth

Product number: OP29952
Product name: Polyinosinic acid, homopolymer, complex with polycytidylic acid, homopolymer (1:1)
Packaging: 1g
Price: $80
Updated: 2021/12/16

More

Less

Polyinosinic acid-polycytidylic acid Chemical Properties,Usage,Production

Uses

Poly(I:C) is a toll-like receptor 3 dsRNA inflammatory stimulant.

Definition

ChEBI: A mismatched double-stranded RNA with one strand being a polymer of inosinic acid, the other a polymer of cytidylic acid.

Biological Activity

poly (i:c), a synthetic double-stranded rna (dsrna) analog, is an immunostimulant that acts as the most potent interferon (ifn) inducer. toll-like receptor- 3 (tlr3) agonist[1].mixtures that included the tlr7/8 agonists r848 or cl075, combined with the poly (i:c), yield 3-d mature dendritic cells [2].commonly used to stimulate immune system activation in vivo. also promotes maturation of hpsc-derived cardiomyocytes[3].[1]. li y g, siripanyaphinyo u, tumkosit u, et al. poly (i:c), an agonist of toll-like receptor-3, inhibits replication of the chikungunya virus in beas-2b cells. virology journal, 2012, 9(1): 114.[2]. spranger s, javorovic m, burdek m, et al. generation of th1-polarizing dendritic cells using the tlr7/8 agonist cl075. the journal of immunology, 2010, 185(1): 738-747.[3]. biermann m1, cai w2, lang d, et al. epigenetic priming of human pluripotent stem cell-derived cardiac progenitor cells accelerates cardiomyocyte maturation. stem cells, 2019, 37(7): 910-923.

in vivo

Polyinosinic-polycytidylic acid (2.5-10 mg/mL, Stereotaxic injection, single dose) induces a sustained inflammatory reaction in the substantia nigra (SN) and in the dorsolateral striatum. ^[2].
Polyinosinic-polycytidylic acid (10 μg/mouse, Intraperitoneal injection, single dose) decreases lung tumor growth in mice^[3].
Polyinosinic-polycytidylic acid (1.25 mg/kg, Intraperitoneal injection, single dose) exerts therapeutic effects against cerebral I/R injury through the downregulation of TLR4/MyD88 signaling via TLR3 in MCAO model mice^[5].

Animal Model:	lung tumor-bearing mice^[3]
Dosage:	10 μg/mouse
Administration:	Intraperitoneal injection (i.p.)
Result:	Induced a significant decrease in the growth of pulmonary metastases in tumor-bearing mice. Reduced the amount of lung foci to ≈ 40%. Significantly increased BAL fluid cell numbers. Increased the level of INF-γ and IL-17A, decreased the levels of IL-13. Increased TLR3 expression.

Animal Model:	Middle cerebral artery occlusion (MCAO) model mice^[5]
Dosage:	1.25 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Reduced focal cerebral I/R injury. Increased the expression of Bcl2, Hsp27, and Hsp70, decreased Bax expression, and reduced cellular degeneration and apoptosis. Protected against cerebral ischemia and conferred protection against cerebral I/R injury through the downregulation of TLR4 signaling via TLR3.

IC 50

Bcl-2; Bax; IL-17A; IL-13; HSP70

Polyinosinic acid-polycytidylic acid Preparation Products And Raw materials

Raw materials

Yttrium oxide sulfate, terbium-doped Carbodiimide 5'—NUCLEOTIDE Cytidine 5’-monophosphate TAQ DNA POLYMERASE 5U/UL Creatine Microcrystalline cellulose Tributylamine Ribonucleic acid Sodium nitrite Agar Anhydrous pyridine Inosinic Acid Epichlorohydrin SULFATE STANDARD POLYNUCLEOTIDE PHOSPHORYLASE FROM BACIL Morpholine Ammonium sulfate

Preparation Products

More

Less

Polyinosinic acid-polycytidylic acid Suppliers

Canada 1 China 262 Germany 1 Switzerland 1 United Kingdom 2 United States 15 Global 282

HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10648
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19552
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: sales@advtechind.com
Country: United States
ProdList: 6075
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

Creative Enzymes

Tel: 1-516-855-7709
Fax: 1-631-938-8127
Email: info@creative-enzymes.com
Country: United States
ProdList: 8748
Advantage: 58

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Beta Pharma, Inc.

Tel: --
Fax: --
Email: sales@betapharma.com
Country: United States
ProdList: 6226
Advantage: 60

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Creative Enzymes

Tel: --
Fax: --
Email: info@creative-enzymes.com
Country: United States
ProdList: 6057
Advantage: 58

MP Biomedicals, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 6561
Advantage: 81

BOSCHE SCIENTIFIC, LLC

Tel: --
Fax: --
Email: Sales@BoscheSci.com
Country: United States
ProdList: 6477
Advantage: 55

Amersham Biosciences, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 1270
Advantage: 85

More

Less

View Lastest Price from Polyinosinic acid-polycytidylic acid manufacturers

Hangzhou Meiya Pharmaceutical Co Ltd

Product: Polyinosinic-polycytidylic acid sodium salt (PIC) 24939-03-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: ≥90.0%
Supply Ability: 10 tons
Release date: 2024-02-06

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Polycytidylic Acid 24939-03-5
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-11-21

Hebei Chuanghai Biotechnology Co., Ltd

Product: Polyinosinic-polycytidylic acid sodium salt 24939-03-5
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2025-03-07

24939-03-5, Polyinosinic acid-polycytidylic acidRelated Search:

Glycine Folic acid Ethyl 2-(Chlorosulfonyl)acetate Cytidine 5’-monophosphate L-DIHYDROOROTIC ACID Cytidine-5'-triphosphate disodium salt dihydrate 5-Azacytidine Cytarabine Citric acid Ascoric Acid 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE N-BUTYLISOCYANIDE Cupric acetylacetonate TERT-BUTYL ISOCYANIDE Tosylmethyl isocyanide Aluminum acetylacetonate Inosinic Acid Ethyl isocyanoacetate

POLY(I) POLY(C)

POLYINOSINIC ACID POLYCYTIDYLIC ACID

POLYINOSINIC POLYCYTIDYLIC ACID

polyinosinic:polycytidylic acid copolymer

POLYCYTIDYLIC-INOSINIC ACID

Polyinosinic-polytidylin Acid.

POLYINOSINIC ACID . POLYCYTIDYLIC ACID, LYOPHILIZED

POLYCYTIDYLIC-INOSINIC ACID POTASSIUM

Polyinosinic

Polyinosinic Polycytidylic

POLYINOSINIC-POLYCYTIDILICACIDKSALT

Poly inosine-cytidine

5’-inosinicacid,homopolymer,complexwith5’-cytidylicacidhomopolymer(1:

5’-Inosinicacid,homopolymer,complexwith5’-cytidylicacidhomopolymer(1:1)

polyi:c

polyi-c

polyri:polyrc

Polycytidysic acid (Poly C)

Polyinosinic acid-po

nsc-120949

poly(i).poly(c)complex

poly(i+c)

poly(ri).(rc)

poly(ri).poly(rc)

poly(ri:rc)

polycpolyi

polycytidylic-polyinosinicacid

Polyinosinic-cytidylic acid disodiuM salt

Poly(I:C) (~90%)

Polyinosinic acid: polycytidylic acid (poly I:C)

Polyinosinic acid-polycytidylic acid USP/EP/BP

Poly I:Cr

Polyadenosinic acid sodium salt，Poly A

Poly-Na

Polyinosinic-polycytidylic acid sodium salt (PIC)

CID 135618150

[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate

Glycine Impurity 24

Polyinosinic acid-polycytidylic acid, homopolymer (1:1)

Double stranded polymeric muscle cells 90%

Double stranded polymeric muscle cells

24939-03-5

C10H11N4O7PnC9H12N3O7PnC38H50

C10H13N4O8PC9H14N3O8P

C19H27N7O16P2

C10H13N4O8PxC9H14N3O8Px

Nucleosides, Nucleotides, Oligonucleotides

Synthetic Oligonucleotides and Related Reagents

Biochemicals and Reagents

BioChemical

Material