5-Methyl-2-thiophenecarboxylic acid

Product Name: 5-Methyl-2-thiophenecarboxylic acid
CAS No.: 1918-79-2
Chemical Name: 5-Methyl-2-thiophenecarboxylic acid
Synonyms: 5-METHYLTHIOPHENE-2-CARBOXYLIC ACID;2-Thiophenecarboxylic acid, 5-methyl-;AKOS B000091;TIMTEC-BB SBB004146;RARECHEM AL BE 0181;5-METHYL-2-THENOIC ACID;Rivaroxaban Impurity 51;2-Carboxy-5-methylthiophene;ethyl-2-thiophenecarboxylic acid;5-Methylthiophen-2-carboxylic acid
CBNumber: CB3183843
Molecular Formula: C6H6O2S
Formula Weight: 142.18
MOL File: 1918-79-2.mol

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5-Methyl-2-thiophenecarboxylic acid Property

Melting point:: 135-138 °C(lit.)
Boiling point:: 229.75°C (rough estimate)
Density: 1.365 (estimate)
refractive index: 1.5300 (estimate)
storage temp.: 2-8°C(protect from light)
form: Liquid
pka: 3.71±0.10(Predicted)
color: Clear
BRN: 113857
InChI: InChI=1S/C6H6O2S/c1-4-2-3-5(9-4)6(7)8/h2-3H,1H3,(H,7,8)
InChIKey: VCNGNQLPFHVODE-UHFFFAOYSA-N
SMILES: C1(C(O)=O)SC(C)=CC=1
CAS DataBase Reference: 1918-79-2(CAS DataBase Reference)
NIST Chemistry Reference: 5-Methyl-2-thiophenecarboxylic acid (keto form)(1918-79-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M84429
Product name: 5-Methyl-2-thiophenecarboxylic acid
Purity: 99%
Packaging: 5g
Price: $41.1
Updated: 2023/06/20

Sigma-Aldrich

Product number: M84429
Product name: 5-Methyl-2-thiophenecarboxylic acid
Purity: 99%
Packaging: 25g
Price: $255
Updated: 2022/05/15

TCI Chemical

Product number: M1118
Product name: 5-Methyl-2-thiophenecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $49
Updated: 2025/07/31

TRC

Product number: B486023
Product name: 5-Methylthiophene-2-carboxylicAcid
Packaging: 500mg
Price: $60
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK207658
Product name: 5-Methyl-2-thiophenecarboxylic Acid
Purity: 99%
Packaging: 5g
Price: $62
Updated: 2021/12/16

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5-Methyl-2-thiophenecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

BEIGE CRYSTALLINE POWDER

Definition

ChEBI: 5-Methyl-2-thiophenecarboxylic acid is a thiophenecarboxylic acid.

Synthesis Reference(s)

Tetrahedron Letters, 15, p. 2373, 1974 DOI: 10.1016/S0040-4039(01)92259-2

Synthesis

13679-74-8

1918-79-2

GENERAL PROCEDURE: The general procedure for the synthesis of 5-methyl-2-thiophenecarboxylic acid from 2-acetyl-5-methylthiophene was as follows: Oxone (2 eq.) and trifluoroacetic acid (TFA, 2 eq.) were added to a solution of 2-acetyl-5-methylthiophene (100 mg, 1 eq.) in dioxane (5 mL). The reaction mixture was heated to reflux for 10 hours and subsequently cooled to room temperature. Water (10 mL) was added and the mixture was extracted with ethyl acetate (EtOAc, 2 x 20 mL). The organic layers were combined and washed with saturated sodium bicarbonate (NaHCO3) solution. The sodium bicarbonate solution and the aqueous layer were poured onto crushed ice and acidified with 2 M hydrochloric acid (HCl), at which point a colorless solid precipitated. The precipitate was collected by filtration, dried under vacuum and purified by column chromatography (silica gel; ethyl acetate-hexane, 1:9) to give 5-methyl-2-thiophenecarboxylic acid as a white crystalline solid. Yield: 0.096 g (95% based on 2-acetyl-5-methylthiophene); melting point: 122-123 °C.

References

[1] Synthesis (Germany), 2015, vol. 47, # 20, p. 3161 - 3168
[2] Journal of the American Chemical Society, 1947, vol. 69, p. 3096
[3] Recueil des Travaux Chimiques des Pays-Bas, 1949, vol. 68, p. 5,29

5-Methyl-2-thiophenecarboxylic acid Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from 5-Methyl-2-thiophenecarboxylic acid manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: 5-Methyl-2-thiophenecarboxylic acid 1918-79-2
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99.8%
Supply Ability: 100tons
Release date: 2024-08-15

Shanghai kingmorn biotechnology Co.,LTD.

Product: 5-Methyl-2-thiophenecarboxylic acid 1918-79-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: >100KG
Release date: 2021-07-20

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-Methyl-2-thiophenecarboxylic acid 1918-79-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

1918-79-2, 5-Methyl-2-thiophenecarboxylic acidRelated Search:

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ethyl-2-thiophenecarboxylic acid

1918-79-2

CH3C4H2SCOOH

ARYL ACID

Building Blocks

Thiophenes

Heterocyclic Building Blocks

Building Blocks

Heterocyclic Building Blocks

Thiophenes

Thiophene&Benzothiophene

Organic acids

Heterocyclic Compounds

Thiophens

Acids and Derivatives

Heterocycles