PNU 100480

ChemicalBook > CAS DataBase List > PNU 100480

Product Name: PNU 100480
CAS No.: 168828-58-8
Chemical Name: PNU 100480
Synonyms: CS-2604;U-100480;Sutezolid;PNU 100480;PF-02341272;Sutezolid 13C4;Sutezolid (PNU-100480);Sutezolid >=98% (HPLC);PNU-100480; U-100480; PF-02341272;Sutezolid (PNU-100480, PF-02341272)
CBNumber: CB32628274
Molecular Formula: C16H20FN3O3S
Formula Weight: 353.41
MOL File: 168828-58-8.mol

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PNU 100480 Property

Melting point:: 186-187°C
Boiling point:: 609.0±55.0 °C(Predicted)
Density: 1.321±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: soluble20mg/mL, clear
form: powder
pka: 15.53±0.46(Predicted)
color: white to beige
optical activity: [α]/D -8 to -12°, c = 1 in chloroform-d

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 45

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0035
Product name: Sutezolid
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0035
Product name: Sutezolid
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $483
Updated: 2024/03/01

Cayman Chemical

Product number: 28395
Product name: PNU 100480
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 28395
Product name: PNU 100480
Packaging: 50mg
Price: $546
Updated: 2024/03/01

Cayman Chemical

Product number: 28395
Product name: PNU 100480
Packaging: 10mg
Price: $152
Updated: 2024/03/01

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PNU 100480 Chemical Properties,Usage,Production

Description

PNU 100480 is an oxazolidinone antibiotic that is active against multidrug resistant tuberculosis. It inhibits the growth of M. tuberculosis replicating and nonreplicating strains (MIC = ~400 ng/ml for both) and of clinical isolates that are susceptible or resistant to a combination of isoniazid , rifampin (rifampicin; ), ethambutol , and streptomycin (; MICs = ≤0.0625-0.5 mg/L). It also inhibits the growth of P. insidiosum and P. aphanidermatum clinical isolates (MICs = 4-64 μg/ml). PNU 100480 (100 mg/kg per day) decreases the number of colony forming units (CFU) in the lung in a mouse model of systemic nonreplicating M. tuberculosis infection.

Uses

Sutezolid is an oxazolidinone antibacterial agent analog. Sutezolid is a promising antimycobacterial agent (tuberculostatic).

Biochem/physiol Actions

Sutezolid (PNU 100480) is an oxazolidinone antimicrobial. Sutezolid inhibits protein synthesis by inhibiting bacterial mRNA translation. Sutezolid is being investigated for the treatment of multiple drug–resistant and extensively drug-resistant tuberculosis. The compound is a less toxic and more potent derivative of linezolid.

PNU 100480 Preparation Products And Raw materials

Raw materials

Preparation Products

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PNU 100480 Suppliers

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168828-58-8, PNU 100480Related Search:

PF-06700841-TsOH PF-06700841 tosylate PF-06282999 PF 4618433 PF-06650833 PF-6260933 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- PF-01247324 PF 04995274 PF 05175157 PF-06281355 PF06869206

PNU 100480

(S)-N-[[3-[3-Fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide

Sutezolid

(S)-N-((3-(3-fluoro-4-thiomorpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

(S)-N-((3-(3-fluoro-4-thiomorpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide(WXC06631)

PF-02341272

Sutezolid (PNU-100480, PF-02341272)

PNU-100480; U-100480; PF-02341272

U-100480

PNU 100480 - PF 02341272 | U 100480 | Sutezolid

CS-2604

Sutezolid (PNU-100480)

Acetamide, N-[[(5S)-3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-

Sutezolid >=98% (HPLC)

N-[[(5S)-3-(3-fluoro-4-thiomorpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide

Sutezolid 13C4

U 100480,oxazolidinone,Antibiotic,protein,Sutezolid,synthesis,Bacterial,Inhibitor,PF 02341272,inhibit,PF02341272,U100480,antimicrobial,tuberculosis,PNU 100480,PNU100480

N-({(5S)-3-[3-Fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-1,3- oxazolidin-5-yl}methyl)acetamide

168828-58-8