ChemicalBook > CAS DataBase List > PNU 100480

PNU 100480

Product Name
PNU 100480
CAS No.
168828-58-8
Chemical Name
PNU 100480
Synonyms
CS-2604;U-100480;Sutezolid;PNU 100480;PF-02341272;Sutezolid 13C4;Sutezolid (PNU-100480);Sutezolid >=98% (HPLC);Sutezolid, 10 mM in DMSO;PNU-100480; U-100480; PF-02341272
CBNumber
CB32628274
Molecular Formula
C16H20FN3O3S
Formula Weight
353.41
MOL File
168828-58-8.mol
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PNU 100480 Property

Melting point:
186-187°C
Boiling point:
609.0±55.0 °C(Predicted)
Density 
1.321±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
pka
15.53±0.46(Predicted)
color 
white to beige
optical activity
[α]/D -8 to -12°, c = 1 in chloroform-d
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
45
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0035
Product name
Sutezolid
Purity
≥98% (HPLC)
Packaging
5mg
Price
$118
Updated
2024/03/01
Sigma-Aldrich
Product number
PZ0035
Product name
Sutezolid
Purity
≥98% (HPLC)
Packaging
25mg
Price
$483
Updated
2024/03/01
Cayman Chemical
Product number
28395
Product name
PNU 100480
Packaging
5mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
28395
Product name
PNU 100480
Packaging
50mg
Price
$546
Updated
2024/03/01
Cayman Chemical
Product number
28395
Product name
PNU 100480
Packaging
10mg
Price
$152
Updated
2024/03/01
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PNU 100480 Chemical Properties,Usage,Production

Description

PNU 100480 is an oxazolidinone antibiotic that is active against multidrug resistant tuberculosis. It inhibits the growth of M. tuberculosis replicating and nonreplicating strains (MIC = ~400 ng/ml for both) and of clinical isolates that are susceptible or resistant to a combination of isoniazid , rifampin (rifampicin; ), ethambutol , and streptomycin (; MICs = ≤0.0625-0.5 mg/L). It also inhibits the growth of P. insidiosum and P. aphanidermatum clinical isolates (MICs = 4-64 μg/ml). PNU 100480 (100 mg/kg per day) decreases the number of colony forming units (CFU) in the lung in a mouse model of systemic nonreplicating M. tuberculosis infection.

Uses

Sutezolid is an oxazolidinone antibacterial agent analog. Sutezolid is a promising antimycobacterial agent (tuberculostatic).

Biochem/physiol Actions

Sutezolid (PNU 100480) is an oxazolidinone antimicrobial. Sutezolid inhibits protein synthesis by inhibiting bacterial mRNA translation. Sutezolid is being investigated for the treatment of multiple drug–resistant and extensively drug-resistant tuberculosis. The compound is a less toxic and more potent derivative of linezolid.

PNU 100480 Preparation Products And Raw materials

Raw materials

Preparation Products

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PNU 100480 Suppliers

China 63 India 4 United States 11 Global 78
UHN Shanghai Research & Development Co., Ltd.
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168828-58-8, PNU 100480Related Search:

PF-06700841-TsOH PF-06700841 tosylate PF-06282999 PF 4618433 PF-06650833 PF-6260933 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- PF-01247324 PF 04995274 PF 05175157 PF-06281355 PF06869206

  • PNU 100480
  • (S)-N-[[3-[3-Fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide
  • Sutezolid
  • (S)-N-((3-(3-fluoro-4-thiomorpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
  • (S)-N-((3-(3-fluoro-4-thiomorpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide(WXC06631)
  • PF-02341272
  • Sutezolid (PNU-100480, PF-02341272)
  • PNU-100480; U-100480; PF-02341272
  • U-100480
  • PNU 100480 - PF 02341272 | U 100480 | Sutezolid
  • CS-2604
  • Sutezolid (PNU-100480)
  • Acetamide, N-[[(5S)-3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-
  • Sutezolid >=98% (HPLC)
  • N-[[(5S)-3-(3-fluoro-4-thiomorpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
  • Sutezolid 13C4
  • U 100480,oxazolidinone,Antibiotic,protein,Sutezolid,synthesis,Bacterial,Inhibitor,PF 02341272,inhibit,PF02341272,U100480,antimicrobial,tuberculosis,PNU 100480,PNU100480
  • N-({(5S)-3-[3-Fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-1,3- oxazolidin-5-yl}methyl)acetamide
  • Sutezolid, 10 mM in DMSO
  • 168828-58-8