ChemicalBook > CAS DataBase List > N-BOC-piperidine-4-carboxylic acid

N-BOC-piperidine-4-carboxylic acid

Product Name
N-BOC-piperidine-4-carboxylic acid
CAS No.
84358-13-4
Chemical Name
N-BOC-piperidine-4-carboxylic acid
Synonyms
1-(TERT-BUTOXYCARBONYL)PIPERIDINE-4-CARBOXYLIC ACID;BOC-INP-OH;BOC-ISONIPECOTIC ACID;BOC-INP;Boc-DL-Inp-OH;BOC-PIC(4)-OH;AURORA KA-3052;BUTTPARK 99\04-45;RARECHEM AH CK 0061;Bilastine Impurity 74
CBNumber
CB3282481
Molecular Formula
C11H19NO4
Formula Weight
229.27
MOL File
84358-13-4.mol
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N-BOC-piperidine-4-carboxylic acid Property

Melting point:
148-153 °C
Boiling point:
353.2±35.0 °C(Predicted)
Density 
1.164±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
4.56±0.20(Predicted)
form 
Crystalline Powder
color 
White
Water Solubility 
Insoluble in water.
BRN 
5533442
InChI
InChI=1S/C11H19NO4/c1-11(2,3)16-10(15)12-6-4-8(5-7-12)9(13)14/h8H,4-7H2,1-3H3,(H,13,14)
InChIKey
JWOHBPPVVDQMKB-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC(C(O)=O)CC1
CAS DataBase Reference
84358-13-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39-24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
15518
Product name
Boc-Inp-OH
Purity
≥99.0% (HPLC)
Packaging
5g
Price
$193
Updated
2025/07/31
TCI Chemical
Product number
B3241
Product name
1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic Acid
Purity
>96.0%(GC)(T)
Packaging
5g
Price
$52
Updated
2025/07/31
TCI Chemical
Product number
B3241
Product name
1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic Acid
Purity
>96.0%(GC)(T)
Packaging
25g
Price
$150
Updated
2025/07/31
Usbiological
Product number
261874
Product name
N-Boc-isonipecotic acid
Packaging
50g
Price
$319
Updated
2021/12/16
TRC
Product number
B656728
Product name
N-Boc-IsonipecoticAcid
Packaging
100g
Price
$125
Updated
2021/12/16
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N-BOC-piperidine-4-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

It is a pharmaceutical intermediate. he camptothecin ester of isonipecotic acid is installed on a triazine dendrimer intermediate obtained through an iterative, scalable route to ultimately yield cationic and PEGylated targets with activities in cell culture comparable to free drug.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

124443-68-1

84358-13-4

General procedure for the synthesis of 1-Boc-4-piperidinecarboxylic acid from methyl 1-Boc-4-piperidinecarboxylate: 4-tert-butyl-4-methylpiperidine-1,4-dicarboxylate (4.84 g, 20 mmol) and LiOH (2.52 g, 60 mmol) were reacted with 4-tert-butyl-4-methylpiperidine-1,4-dicarboxylate (4.84 g, 20 mmol) and LiOH (2.52 g, 60 mmol) in a mixture of THF (90 mL), MeOH (90 mL) and H2O (30 mL) in a solvent, and the reaction was stirred at room temperature overnight. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was adjusted to pH 2 with aqueous 2N HCl. Subsequently, the reaction mixture was extracted with EtOAc (3 × 20 mL). The organic phases were combined, dried over anhydrous Na2SO4 and concentrated under reduced pressure to give 1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid (4.6 g, 100.0% yield).

References

[1] Patent: WO2012/34526, 2012, A1. Location in patent: Page/Page column 56
[2] Patent: US2013/190307, 2013, A1. Location in patent: Paragraph 0205; 0206
[3] Patent: US2016/102095, 2016, A1. Location in patent: Paragraph 0131
[4] Patent: CN104292233, 2016, B. Location in patent: Paragraph 0047
[5] Patent: WO2016/34134, 2016, A1. Location in patent: Paragraph 00538

N-BOC-piperidine-4-carboxylic acid Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate 1,4-Dioxane Isonipecotic acid Sodium carbonate

Preparation Products

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N-BOC-piperidine-4-carboxylic acid Suppliers

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View Lastest Price from N-BOC-piperidine-4-carboxylic acid manufacturers

Wuhan Boyuan Import & Export Co., LTD
Product
1-boc-piperidine-4-carboxylic acid 84358-13-4
Price
US $45.00-20.00/kg
Min. Order
1kg
Purity
99.60%
Supply Ability
50tons
Release date
2023-04-24
Henan Fengda Chemical Co., Ltd
Product
N-BOC-piperidine-4-carboxylic acid 84358-13-4
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-03
Anhui Zhongda Biotechnology Co., Ltd
Product
N-BOC-piperidine-4-carboxylic acid 84358-13-4
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100tons
Release date
2023-10-24

84358-13-4, N-BOC-piperidine-4-carboxylic acidRelated Search:

2,2,6,6-Tetramethyl-4-piperidinol Maleic acid PHENCYCLIDINE-D5 HYDROCHLORIDE N-BOC-PIPERIDINE-4-CARBOXYLIC ACID METHYL ESTER,N-Boc-Isonipecotic acid methyl ester DROPERIDOL Haloperidol Ethyl 2-(Chlorosulfonyl)acetate Isonipecotic acid Folic acid Ethyl 1-Boc-piperidine-2-carboxylate Ethyl 1-Boc-3-piperidinecarboxylate N-Boc-propargylamine Citric acid N-Boc-2-piperidinecarboxylic acid 1-BOC-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER,1-Boc-isonipecotic acid ethyl ester, 97+% 1-Boc-3-piperidinecarboxylic acid 1-TERT-BUTYL 2-METHYL PIPERIDINE-1,2-DICARBOXYLATE N-BOC-3-Aminopiperidine

  • 1-(TERT-BUTOXYCARBONYL)PIPERIDINE-4-CARBOXYLIC ACID
  • 1-N-BOC-PIPERIDINE-4-CARBOXYLIC ACID
  • N-BOC-PIPERIDINE-4-CARBOXYLIC ACID
  • N-BOC-DL-ISONIPECOTIC ACID
  • N-TERT-BUTYLOXYCARBONYL-PIPERIDINE-4-CARBOXYLIC ACID
  • N-TERT-BUTYLOXYCARBONYL-ISONIPECOTIC ACID
  • N-T-BUTOXYCARBONYL-PIPERIDINE-4-CARBOXYLIC ACID
  • N-T-BUTOXYCARBONYL-HEXAHYDROISONICOTINIC ACID
  • N-TERT-BUTOXYCARBONYL-4-PIPERIDINECARBOXYLIC ACID
  • PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER
  • PIPERIDINE-1,4-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER
  • PIPERIDINE-4-CARBOXYLIC ACID, BOC PROTECTED
  • RARECHEM AH CK 0061
  • 1-BOC-4-PIPERIDINECARBOXYLIC ACID
  • 1-(Tert-butoxycarbonyl)-carboxylic acid
  • 1-(tert-Butoxycarbonyl)isonipecotic acid
  • Boc-DL-Inp-OH
  • AURORA KA-3052
  • BOC-PIC(4)-OH
  • BOC-PIPERIDINE-4-CARBOXYLIC ACID
  • BOC-L-ISONIPECOTIC ACID
  • BOC-ISONICOT(HEXAHYDRO)-OH
  • BOC-ISONIPECOTIC ACID
  • BOC-INP
  • BOC-INP-OH
  • BUTTPARK 99\04-45
  • ISONIPECOTIC ACID, BOC PROTECTED
  • 1-BOC-PIPERIDINE-4-CARBOXYLIC ACID
  • 1-(1,1-DIMETHYLETHYL)1,4-PIPERIDINEDICARBOXYLIC ACID
  • Isonipecotic acid, N-BOC protected, 1-(tert-Butoxycarbonyl)-piperidine-4-carboxylic acid, 1-(tert-Butoxycarbonyl)-4-carboxypiperidine
  • 1-Boc-isonipecotic acid, 98+%
  • 1-Boc-isonipecotic Acid 1-(tert-Butoxycarbonyl)isonipecotic Acid 1-Boc-4-piperidinecarboxylic Acid
  • Boc-piperidine-4-carboxylic acid, Boc-Inp-OH
  • N-BOC-Piperidin-4-carboxylic acid
  • Boc-isonipecotic acid (Boc-piperidine-4-carboxylic acid
  • N-Boc-Piperidine-4-carboxylic acid or N-BOC-isonipecotic acid
  • 1-Boc-isonipecotic acid/1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid
  • N - bok - 4 - piperidine forMic acid
  • Boc-Inp-OH >=99.0% (HPLC)
  • 1-(tert-butoxy-oxomethyl)-4-piperidinecarboxylic acid
  • 1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-4-carboxylic acid
  • (Tert-Butoxy)Carbonyl Inp-OH
  • 1-(t-butoxycarbonyl)-4-(carboxy)piperidine
  • Boc-isonipecotic acid≥ 99% (Assay)
  • New N-BOC-piperidine-4-carboxylic acid
  • N-BOC-4-Piperidinecarboxylic acid
  • 1-Boc-4-piperdinecarboxylic acid
  • Isonipecotic acid, N-BOC protected
  • Piperidine-4-carboxylic acid, N-BOC protected
  • N-Butoxycarbonyl isonipecotic acid
  • 1-(tert-Butoxycarbonyl)piperidine-4-carboxylic acid, tech
  • Piperidine-4-carboxylic acid, N-BOC protected 98%
  • 1-N-Boc-4-piperidinecarboxylicacid
  • N-T-BUTYLOXYCARBONYL-ISONIPECOTIC ACID, N-T-BUTYLOXYCARBONYL-PIPERIDINE-4-CARBOXYLIC ACID
  • N-Boc-Piperidine-4-carboxlic Acid
  • 1-BENZYL-4-PIPERIDINE CARBOXYLIC ACIDN-BENZYL-ISONIPECOTIC ACID
  • 1,4-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester
  • 1-Boc-4-piperidinecarboxylic acid ,98%