ChemicalBook > CAS DataBase List > Bromo-PEG1-CH2CO2tBu

Bromo-PEG1-CH2CO2tBu

Product Name: Bromo-PEG1-CH2CO2tBu
CAS No.: 157759-50-7
Chemical Name: Bromo-PEG1-CH2CO2tBu
Synonyms: tert-Butyl 2-(2-bromoethoxy)acetate;CAS_157759-50-7;Br-PEG1-CH2-Boc;Bromo-PEG1-CH2-Boc;Bromo-PEG1-CH2COOtBu;Bromo-PEG1-CH2CO2tBu;t-butyl acetate-PEG1-bromide;Acetic acid, 2-(2-bromoethoxy)-, 1,1-dimethylethyl ester
CBNumber: CB33062437
Molecular Formula: C8H15BrO3
Formula Weight: 239.11
MOL File: 157759-50-7.mol

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Bromo-PEG1-CH2CO2tBu Property

Boiling point:: 268.1±15.0 °C(Predicted)
Density: 1.301±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
solubility: Soluble in DCM
form: Liquid
color: Colorless to light yellow

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Safety

HS Code: 2920907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-22283
Product name: Bromo-PEG1-CH2CO2tBu
Purity: 98%
Packaging: 100mg
Price: $250
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1338
Product name: Bromo-PEG1-CH2CO2tBu
Packaging: 100mg
Price: $623
Updated: 2021/12/16

Acrotein

Product number: B-0861
Product name: tert-Butyl2-(2-bromoethoxy)acetate
Purity: 97%
Packaging: 0.25g
Price: $183.34
Updated: 2021/12/16

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Bromo-PEG1-CH2CO2tBu Chemical Properties,Usage,Production

Description

Bromo-PEG1-CH2CO2tBu is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Bromo-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Bromo-PEG1-CH2CO2tBu Preparation Products And Raw materials

Raw materials

Preparation Products

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157759-50-7, Bromo-PEG1-CH2CO2tBuRelated Search:

Propyl acetate Tetrabutyl titanate Vinyl acetate TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA Bromo-PEG2-CH2CO2tBu H2N-PEG8-tBu Bromo-PEG4-CH2COOtBu Amino-PEG10-t-butyl ester AMINO-PEG12-T-BUTYL ESTER H2N-PEG6-tBu Amino-PEG5-t-butyl ester H2N-PEG2-tBu Bromo-PEG4-t-butyl ester Bromo-PEG2-t-butyl ester H2N-PEG4-tBu Azido-PEG1-CH2CO2tBu Hydroxy-PEG5-t-butyl acetate Hydroxy-PEG6-CH2CO2tBu

Bromo-PEG1-CH2CO2tBu

Bromo-PEG1-CH2COOtBu

tert-Butyl 2-(2-bromoethoxy)acetate

t-butyl acetate-PEG1-bromide

CAS_157759-50-7

Bromo-PEG1-CH2-Boc

Acetic acid, 2-(2-bromoethoxy)-, 1,1-dimethylethyl ester

Br-PEG1-CH2-Boc

157759-50-7