DIHYDROMETHYSTICIN

Product Name: DIHYDROMETHYSTICIN
CAS No.: 19902-91-1
Chemical Name: DIHYDROMETHYSTICIN
Synonyms: dhm;Nsc112159;PseudoMethysticin;DIHYDROMETHYSTICIN;DIHYDROMETHYLSTICIN;Dihydromethysticin-RM;7,8-dihydromethysticin;7,8-DIHYDROMETHYLSTICIN;Methysticin, 7,8-dihydro-;Dihydroanesthetic capsicin
CBNumber: CB3307966
Molecular Formula: C15H16O5
Formula Weight: 276.28
MOL File: 19902-91-1.mol

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DIHYDROMETHYSTICIN Property

storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly), Pyridine (Slightly)
Boiling point:: 476.1±45.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
Melting point:: 117-118 °C
form: Solid
color: White to Off-White
BRN: 91699
Stability:: Hygroscopic
InChIKey: RSIWXFIBHXYNFM-NSHDSACASA-N
LogP: 1.810 (est)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 52007
Product name: (+)-Dihydromethysticin
Purity: analytical standard
Packaging: 5mg
Price: $539
Updated: 2022/05/15

Cayman Chemical

Product number: 27644
Product name: Dihydromethysticin
Packaging: 5mg
Price: $238
Updated: 2024/03/01

TRC

Product number: B203530
Product name: (6S)-6-[2-(1,3-Benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one
Packaging: 10mg
Price: $375
Updated: 2021/12/16

ChemScene

Product number: CS-4245
Product name: Dihydromethysticin
Packaging: 10mg
Price: $420
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HBL0000233
Product name: (+)-DIHYDROMETHYSTICIN
Purity: 95.00%
Packaging: 5MG
Price: $933.26
Updated: 2021/12/16

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DIHYDROMETHYSTICIN Chemical Properties,Usage,Production

Description

Dihydromethysticin is a kavalactone originally isolated from P. methysticum (kava-kava) that has diverse biological activities, including efflux transporter inhibitory, antinociceptive, and neuroprotective properties. Dihydromethysticin is a P-glycoprotein (P-gp) inhibitor that increases uptake of the P-gp substrate calcein AM by 50% in P388 mouse leukemia cancer cells overexpressing P-gp when used at a concentration of 54.6 μM. Dihydromethysticin (275 mg/kg) has analgesic activity, increasing the latency to tail withdrawal in the tail-flick assay in mice. It also decreases the infarct size in a mouse model of ischemia induced by microbipolar coagulation of the left middle cerebral artery (MCA) when administered at a dose of 10 mg/kg.

Uses

(6S)-6-[2-(1,3-Benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one, is used in toxicity studies through in vitro analysis. This complex is found in the roots of kava plant.

Definition

ChEBI: Dihydromethysticin is a member of 2-pyranones and an aromatic ether.

DIHYDROMETHYSTICIN Preparation Products And Raw materials

Raw materials

Preparation Products

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DIHYDROMETHYSTICIN Suppliers

China 111 Germany 1 United Kingdom 3 United States 13 USA 1 Global 129

MedChemexpress LLC

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Musechem

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TargetMol Chemicals Inc.

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ChromaDex

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View Lastest Price from DIHYDROMETHYSTICIN manufacturers

Career Henan Chemical Co

Product: DIHYDROMETHYSTICIN 19902-91-1
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-10

19902-91-1, DIHYDROMETHYSTICINRelated Search:

DIHYDROKAVAIN YANGONIN FLAVOKAWAINC FLAVOKAVAIN A(P) L-KAWAIN Kavain METHYSTICIN DIHYDROMETHYSTICIN DIHYDROMETHYSTICIN(P) Dihydrokawain DIHYDROMETHYSTICIN 5,6-DIHYDRO-2H-PYRAN-2-ONE 5,6-DIHYDRO-4-METHOXY-2H-PYRAN 3-BENZO[1,3]DIOXOL-5-YL-PROPAN-1-OL 1-PHENYL-HEX-5-EN-3-OL 5,6-DIHYDRO-4-HYDROXY-6-METHYL-2H-PYRAN-2-ONE DIHYDROMETHYSTICIN SNAP-N-SHOOT 0.1mg/mL(P) PARASORBICACID

6-(2-(1,3-benzodioxol-5-yl)ethyl)-5,6-dihydro-4-methoxy-2h-pyran-2-on(s)

6-dihydro-4-methoxy-6-(3,4-(methylenedioxy)phenethyl)-(s)-2h-pyran-2-on

7,8-dihydromethysticin

dhm

DIHYDROMETHYLSTICIN

7,8-DIHYDROMETHYLSTICIN

5,6-Dihydro-4-methoxy-6-[2-(1,3-benzodioxol-5-yl)ethyl]-2H-pyran-2-one

6-[2-(1,3-Benzodioxol-5-yl)ethyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one

2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-[3,4-(methylenedioxy)phenethyl]-, (S)-

2H-Pyran-2-one, 6-[2-(1,3-benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-, (S)-

Methysticin, 7,8-dihydro-

Nsc112159

PseudoMethysticin

Dihydromethysticin ((+)-Dihydromethysticin)

(6S)-6-[2-(1,3-Benzodioxol-5-yl)ethyl]-5,6-dihydro-4-Methoxy-2H-pyran-2-one

DIHYDROMETHYSTICIN

2H-Pyran-2-one, 6-[2-(1,3-benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-, (6S)-

Dihydromethysticin,Inhibitor,inhibit,CYPs,Cytochrome P450

(S)-6-(2-(Benzo[d][1,3]dioxol-5-yl)ethyl)-4-methoxy-5,6-dihydro-2H-pyran-2-one

Dihydroanesthetic capsicin

Dihydromethysticin-RM

19902-91-1

Coumarins