ChemicalBook > CAS DataBase List > 4-(BROMOMETHYL)-2-FLUOROBENZONITRILE

4-(BROMOMETHYL)-2-FLUOROBENZONITRILE

Product Name
4-(BROMOMETHYL)-2-FLUOROBENZONITRILE
CAS No.
222978-03-2
Chemical Name
4-(BROMOMETHYL)-2-FLUOROBENZONITRILE
Synonyms
4-CYANO-3-FLUOROBENZYL BROMIDE;4-Cyano-3-fluorobenzylbromide98%;4-Cyano-3-fluorobenzyl bromide 98%;4-(BROMOMETHYL)-2-FLUOROBENZONITRILE;Benzonitrile, 4-(bromomethyl)-2-fluoro-;4-(Bromomethyl)-2-fluorobenzonitrile 98%;4-Cyano-3-fluorobenzyl bromide, alpha-Bromo-2-fluoro-p-tolunitrile
CBNumber
CB3339303
Molecular Formula
C8H5BrFN
Formula Weight
214.03
MOL File
222978-03-2.mol
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4-(BROMOMETHYL)-2-FLUOROBENZONITRILE Property

Melting point:
44-45 °C
Boiling point:
275.6±30.0 °C(Predicted)
Density 
1.59±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Methanol (Slightly)
form 
Solid
color 
Off-White
Sensitive 
Lachrymatory
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Safety

Hazard Codes 
C,Xn
Risk Statements 
20/21/22
Safety Statements 
36/37
Hazard Note 
Corrosive/Lachrymatory
HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B697158
Product name
4-(Bromomethyl)-2-fluorobenzonitrile
Packaging
1g
Price
$50
Updated
2021/12/16
TRC
Product number
B697158
Product name
4-(Bromomethyl)-2-fluorobenzonitrile
Packaging
10g
Price
$160
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC37300
Product name
4-Cyano-3-fluorobenzyl bromide
Packaging
500mg
Price
$80
Updated
2021/12/16
Apolloscientific
Product number
PC5928
Product name
4-(Bromomethyl)-2-fluorobenzonitrile
Purity
98%
Packaging
5g
Price
$124
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC37300
Product name
4-Cyano-3-fluorobenzyl bromide
Packaging
1g
Price
$125
Updated
2021/12/16
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4-(BROMOMETHYL)-2-FLUOROBENZONITRILE Chemical Properties,Usage,Production

Uses

4-(Bromomethyl)-2-fluorobenzonitrile is a useful building block for the preparation and optimization of the highly selective GLUT1 inhibitor, BAY-876.

Synthesis

85070-67-3

222978-03-2

2-Fluoro-4-methylbenzonitrile (10 g, 74.07 mmol) was used as a raw material, which was dissolved in 200 mL of chloroform, 1 g of benzoyl peroxide (BPO) was added, and stirred until completely dissolved. Subsequently, N-bromosuccinimide (NBS, 19.77 g, 11.11 mmol) was added in batches and the reaction mixture was refluxed for 12 hours. After completion of the reaction, it was cooled to room temperature and washed three times with saturated aqueous sodium bicarbonate solution, then three times with appropriate amount of water and finally three times with saturated brine. The solvent was removed by evaporation under reduced pressure and purified by column chromatography to give the light yellow liquid product 4-cyano-3-fluorobenzyl bromide (14.00 g) in 88.79% yield.

References

[1] Patent: CN106810552, 2017, A. Location in patent: Paragraph 0068; 0070; 0071
[2] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 1325 - 1344
[3] Organic and Biomolecular Chemistry, 2004, vol. 2, # 9, p. 1339 - 1352
[4] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 20, p. 2925 - 2930
[5] Journal of the American Chemical Society, 2001, vol. 123, # 9, p. 2107 - 2108

4-(BROMOMETHYL)-2-FLUOROBENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(BROMOMETHYL)-2-FLUOROBENZONITRILE Suppliers

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View Lastest Price from 4-(BROMOMETHYL)-2-FLUOROBENZONITRILE manufacturers

Henan Fengda Chemical Co., Ltd
Product
4-(BROMOMETHYL)-2-FLUOROBENZONITRILE 222978-03-2
Price
US $101.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-28

222978-03-2, 4-(BROMOMETHYL)-2-FLUOROBENZONITRILERelated Search:

6-CHLORO-1-METHYLURACIL Trelagliptin Impurity 24 2-(Bromomethyl)-6-fluorobenzonitrile 4-Fluoro-2-methylbenzonitrile N-METHYLBARBITURIC ACID Trelagliptin Impurity Y Trelagliptin Impurity 20 2-Bromo-5-fluorotoluene alpha-Cyclopentylmandelic acid Trelagliptin Impurity 18 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione 2-(DibroMoMethyl)-4-fluorobenzonitrile Trelagliptin Impurity 19 Trelagliptin Impurity 17 Dimethyl sulfate 4-(BROMOMETHYL)-3-FLUOROBENZONITRILE 4-Cyanobenzyl bromide 2-Fluoro-4-methylbenzonitrile

  • 4-Cyano-3-fluorobenzyl bromide 98%
  • 4-Cyano-3-fluorobenzylbromide98%
  • 4-CYANO-3-FLUOROBENZYL BROMIDE
  • 4-(BROMOMETHYL)-2-FLUOROBENZONITRILE
  • 4-(Bromomethyl)-2-fluorobenzonitrile 98%
  • 4-Cyano-3-fluorobenzyl bromide, alpha-Bromo-2-fluoro-p-tolunitrile
  • Benzonitrile, 4-(bromomethyl)-2-fluoro-
  • 222978-03-2
  • Fluorine series