5-Bromonicotinic acid

Product Name: 5-Bromonicotinic acid
CAS No.: 20826-04-4
Chemical Name: 5-Bromonicotinic acid
Synonyms: 5-BROMOPYRIDINE-3-CARBOXYLIC ACID;Nicergoline impurity D CRS;5-BROMO-3-PYRIDINECARBOXYLIC ACID;DF97;AURORA KA-3027;CAS:20826-04-4;AKOS BBS-00007710;5 - broMine niacin;TIMTEC-BB SBB003524;RARECHEM AL BO 0841
CBNumber: CB3375701
Molecular Formula: C6H4BrNO2
Formula Weight: 202.01
MOL File: 20826-04-4.mol

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5-Bromonicotinic acid Property

Melting point:: 178-180 °C(lit.)
Boiling point:: 259.67°C (rough estimate)
Density: 1.7477 (rough estimate)
vapor pressure: 0.01Pa at 25℃
refractive index: 1.6120 (estimate)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Powder
pka: 3.08±0.10(Predicted)
color: White to yellow-gray or light brown
BRN: 115854
InChI: InChI=1S/C6H4BrNO2/c7-5-1-4(6(9)10)2-8-3-5/h1-3H,(H,9,10)
InChIKey: FQIUCPGDKPXSLL-UHFFFAOYSA-N
SMILES: C1=NC=C(Br)C=C1C(O)=O
LogP: 1.17-1.29 at 23.5℃ and pH6.4
CAS DataBase Reference: 20826-04-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-24/25
WGK Germany: 3
RTECS: QT0868000
HazardClass: IRRITANT
HS Code: 29333999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 228435
Product name: 5-Bromopyridine-3-carboxylic acid
Purity: 98%
Packaging: 10g
Price: $40.68
Updated: 2024/03/01

Sigma-Aldrich

Product number: 228435
Product name: 5-Bromopyridine-3-carboxylic acid
Purity: 98%
Packaging: 50g
Price: $59.6
Updated: 2024/03/01

TCI Chemical

Product number: B1818
Product name: 5-Bromonicotinic Acid
Purity: >99.0%(GC)(T)
Packaging: 25g
Price: $59
Updated: 2024/03/01

Alfa Aesar

Product number: A13589
Product name: 5-Bromonicotinic acid, 98%
Packaging: 25g
Price: $72.7
Updated: 2021/12/16

Alfa Aesar

Product number: A13589
Product name: 5-Bromonicotinic acid, 98%
Packaging: 5g
Price: $26.1
Updated: 2021/12/16

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5-Bromonicotinic acid Chemical Properties,Usage,Production

Chemical Properties

Light yellow Cryst

Uses

5-Bromopyridine-3-carboxylic acid (5-bromonicotinic acid) was used in the synthesis of 3-guanidinomethyl-5-iodopyridine.

Reactions

5-Bromonicotinic acid could used as starting material to synthesize 3-guanidinomethyl-5-iodopyridine. It is also used to prepare four novel multifunctional coordination compounds with different lanthanide(III) ions (Dy, Tb, Yb, and Nd). These materials possess different structures and dimensionalities and show interesting magnetic and luminescence properties, as well as a complete absence of cytotoxicity both in cancer and non-cancer Caco-2 cells[1-2].

Synthesis Reference(s)

Journal of the American Chemical Society, 70, p. 2381, 1948 DOI: 10.1021/ja01187a020

Purification Methods

The acid is recrystallised from H2O and then from EtOH using charcoal. The amide has m 219-219.5o (from aqueous EtOH), and the methyl ester, prepared by addition of ethereal diazomethane, can be purified by sublimation in a vacuum and has m 98-99o. The acid chloride also can be sublimed in vacuo and has m 74-75o and gives the methyl ester in MeOH. [Graf J Prakt Chem 138 244 1933, Bachman & Micucci J Am Chem Soc 70 2381 1948, Garcia et al. J Am Chem Soc 82 4430 1960, Misic-Vokovic et al. J Chem Soc 34 1978, Beilstein 22/2 V 181.]

References

[1] Vaidyanathan G, et al. Iodopyridine-for-iodobenzene substitution for use with low molecular weight radiopharmaceuticals: application to m-iodobenzylguanidine. Bioconjugate Chemistry, 1998; 9: 758–764.
[2] Ruiz C, et al. Multifunctional coordination compounds based on lanthanide ions and 5-bromonicotinic acid: magnetic, luminescence and anti-cancer properties. CrystEngComm, 2019; 21: 3881-3890.

5-Bromonicotinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

5-Aminonicotinic acid Methyl 5-aminopyridine-3-carboxylate 5-Fluoronicotinic acid

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5-Bromonicotinic acid Suppliers

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View Lastest Price from 5-Bromonicotinic acid manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 5-Bromonicotinic acid 20826-04-4
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-19

Hebei Weibang Biotechnology Co., Ltd

Product: 5-Bromonicotinic acid 20826-04-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2024-12-04

Hebei Chuanghai Biotechnology Co,.LTD

Product: 5-Bromonicotinic acid 20826-04-4
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-15

20826-04-4, 5-Bromonicotinic acidRelated Search:

Citric acid Folic acid Isonicotinic acid EPA 5-Bromonicotinic acid ethyl ester 97%,Ethyl 5-Bromonicotinic acid ethyl ester,5-BROMONICOTINIC ACID ETHYL ESTER 5-Ethyl-2-(4-isopropyl-4-methyl-5-oxo-1H-imidazolin-2-yl)nicotinic acid Xanthinol nicotinate N,N-Dimethylpropionamide 2,2-Dimethylbutyryl chloride 2-Phenylbutyric acid 5-Bromophthalide 5-Bromoindole 5-Bromopyrimidine 5-Bromo-2-oxindole DIMETHYL 5-BROMOISOPHTHALATE Ascoric Acid Bromine 2-AMINO-5-BROMONICOTINIC ACID,2-Amino-5-bromonicotinic acid 95%,2-Amino-5-bromonicotinic acid ,97%

RARECHEM AL BO 0841

TIMTEC-BB SBB003524

AKOS BBS-00007710

3-PYRIDINECARBOXYLIC ACID, 5-BROMO-

3-BROMO-5-PYRIDINE CARBOXYLIC ACID

3-BROMO PYRIDINE-5-CARBOXYLIC ACID

5-BROMO-3-PYRIDINECARBOXYLIC ACID

5-BROMONICOTINC ACID

5-BROMONICOTINIC ACID

5-BROMOPYRIDINE-3-CARBOXYLIC ACID

5-bromo-3-pyridinecarboxylicaci

5-bromo-nicotinicaci

AURORA KA-3027

IFLAB-BB F3095-3197

5-BromonicotinicAcid98%

5-Bromo-3-pyridinecarboxylic

5-Bromonicotic acid

5-BROMOPYRIDINE-3-CARBOXYLIC ACID / 5-BROMONICOTINIC ACID

5-Bromonicotinic acid, 5-Bromopyridine-3-carboxylic acid

3-Carboxy-5-bromopyridine

5-BROMO NICOTINIC ACID 5-BROMO NICOTINIC ACID

Nicotinic acid, 5-bromo-

5- broMinenicotinic acid

5 - broMine niacin

Nicergoline impurity D

5-Bromopyridine-3-carboxylic acid, 3-Bromo-5-carboxypyridine

5-Bromopyridine-3-carboxylic acid 98%

CAS:20826-04-4

Nicergoline Impurity 4(Nicergoline EP Impurity D)

5-Bromonicotinic Acid &gt

Nicergoline impurity D CRS

Nicergoline EP Impurity D (5-Bromonicotinic acid)

Nicergoline Impurity 4

5-Bromonicotinic acid USP/EP/BP

DF97

5-Bromopyridin-3-carboxylic acid

20826-04-4

Bromopyridines

Halopyridines

Building Blocks

Heterocyclic Building Blocks

Halogenated Heterocycles

Pyridines

Pyridines, Pyrimidines, Purines and Pteredines

pharmacetical

Heterocycles

alkyl bromide|carboxylic acid

Bromopyridines

Halopyridines

Carboxylic Acids

Pyridine series

Carboxylic Acids

Organic acids

Pyridines derivates

PROTECTED AMINO ACID & PEPTIDES

blocks

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