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3-Bromo-5-iodo-pyridine

Product Name
3-Bromo-5-iodo-pyridine
CAS No.
233770-01-9
Chemical Name
3-Bromo-5-iodo-pyridine
Synonyms
Zinc00336771;5-BROMO-3-IODOPYRIDINE;3-BROMO-5-IODO-PYRIDINE;Pyridine, 3-bromo-5-iodo-;3-Bromo-5-iodopyridine >C5H3BrIN 3-BROMO-5-IODOPYRIDINE;3-BroMo-5-iodopyridine;3-Bromo-5-iodo-pyridine ISO 9001：2015 REACH
CBNumber
CB3409686
Molecular Formula
C5H3BrIN
Formula Weight
283.89
MOL File
233770-01-9.mol
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3-Bromo-5-iodo-pyridine Property

Melting point:
127-131 °C
Boiling point:
266.5±25.0 °C(Predicted)
Density 
2.347±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
0.85±0.20(Predicted)
form 
Solid
color 
Off-white
Water Solubility 
Slightly soluble in water.
Sensitive 
Light Sensitive
InChI
InChI=1S/C5H3BrIN/c6-4-1-5(7)3-8-2-4/h1-3H
InChIKey
AOOZLVWDZUPEHT-UHFFFAOYSA-N
SMILES
C1=NC=C(I)C=C1Br
CAS DataBase Reference
233770-01-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-41-22
Safety Statements 
26-36/37/39
WGK Germany 
3
Hazard Note 
Harmful
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
691453
Product name
3-Bromo-5-iodopyridine
Purity
95%
Packaging
1g
Price
$63.2
Updated
2025/07/31
Sigma-Aldrich
Product number
691453
Product name
3-Bromo-5-iodopyridine
Purity
95%
Packaging
250mg
Price
$94.4
Updated
2022/05/15
TCI Chemical
Product number
B4346
Product name
3-Bromo-5-iodopyridine
Purity
>98.0%(GC)
Packaging
1g
Price
$100
Updated
2025/07/31
TCI Chemical
Product number
B4346
Product name
3-Bromo-5-iodopyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$346
Updated
2025/07/31
TRC
Product number
B693623
Product name
3-Bromo-5-iodopyridine
Packaging
250mg
Price
$55
Updated
2021/12/16
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3-Bromo-5-iodo-pyridine Chemical Properties,Usage,Production

Chemical Properties

Off-white Cryst

Uses

Reactant in the synthesis chiral 4, 4?-Bipyridines. 3-bromo-5-(trifluoromethyl)pyridine is prepared from 3-Bromo-5-iodopyridine.

Synthesis

625-92-3

233770-01-9

General procedure for the synthesis of 3-bromo-5-iodopyridine from 3,5-dibromopyridine: 3,5-dibromopyridine (0.52 g, 2.19 mmol) was dissolved in anhydrous tetrahydrofuran (4 mL) at -10 °C, keeping the internal temperature below -5 °C. Subsequently, tetrahydrofuran solution of 2M isopropylmagnesium chloride (0.25 g, 2.11 mmol) and anhydrous tetrahydrofuran solution of iodine (0.62 g, 2.11 mmol) were added sequentially and slowly and stirred for about 5 minutes. After completion of the reaction, the reaction mixture was diluted with ethyl acetate and saturated aqueous sodium bisulfite. The organic layer was separated, dried over magnesium sulfate, filtered and concentrated to afford 3-bromo-5-iodopyridine (4.85 g, 98% yield), which can be used directly for further purification. The product characterization data were as follows: 1H NMR (400 MHz, CDCl3) δ 7.54-7.51 (m, 1H), 8.26 (s, 1H), 8.42 (s, 1H); MS (ES): m/z = 284 [M + H]+.

References

[1] Patent: WO2005/94822, 2005, A1. Location in patent: Page/Page column 35
[2] Chemistry - A European Journal, 2010, vol. 16, # 41, p. 12425 - 12433
[3] European Journal of Organic Chemistry, 2002, # 2, p. 327 - 330
[4] Patent: US2006/4018, 2006, A1. Location in patent: Page/Page column 12; 27
[5] Recueil des Travaux Chimiques des Pays-Bas, 1955, vol. 74, p. 1062,1068

3-Bromo-5-iodo-pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Bromo-5-iodo-pyridine Suppliers

Americas 1 China 172 Europe 2 France 2 Germany 5 India 6 Japan 1 Switzerland 1 The Netherlands 1 United Kingdom 5 United States 23 Global 219
Specs
Tel
--
Fax
--
Email
info@specs.net
Country
The Netherlands
ProdList
6833
Advantage
70
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View Lastest Price from 3-Bromo-5-iodo-pyridine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
3-Bromo-5-iodo-pyridine 233770-01-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%min
Supply Ability
500KGS
Release date
2025-07-17
Honest Joy Holdings Limited
Product
3-Bromo-5-iodopyridine 233770-01-9
Price
US $0.00/KG
Min. Order
1KG
Purity
97.5%
Supply Ability
100 tons
Release date
2022-01-26
Dideu Industries Group Limited
Product
3-Bromo-5-iodo-pyridine 233770-01-9
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-01

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