ChemicalBook > CAS DataBase List > Phenoxyacetic acid

Phenoxyacetic acid

Product Name
Phenoxyacetic acid
CAS No.
122-59-8
Chemical Name
Phenoxyacetic acid
Synonyms
Phenylium;phenoxyacetic;O-PHENYLGLYCOLIC ACID;PHENYLOXYL ACETIC ACID;2-cyclohexyloxyacetate;PHENYLIUM(R);PHENYLIUM(TM);AKOS BBS-00003724;phenoxyacetc acid;Phenxoyacetic acid
CBNumber
CB3485839
Molecular Formula
C8H8O3
Formula Weight
152.15
MOL File
122-59-8.mol
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Phenoxyacetic acid Property

Melting point:
98-100 °C (lit.)
Boiling point:
285 °C
Density 
1.2143 (rough estimate)
refractive index 
1.4447 (estimate)
FEMA 
2872 | PHENOXYACETIC ACID
Flash point:
165 °C
storage temp. 
Store below +30°C.
solubility 
ethanol: soluble10%, clear, colorless
form 
Granular Powder, Granules, or Prills
pka
3.17(at 25℃)
color 
White
Odor
at 1.00 % in propylene glycol. sour sweet
Odor Type
honey
Water Solubility 
0.1-0.5 g/100 mL at 17 ºC
Merck 
14,7254
JECFA Number
1026
BRN 
907949
Stability:
Stable. Substances to be avoided include strong bases, strong oxidizing agents. Combustible.
InChIKey
LCPDWSOZIOUXRV-UHFFFAOYSA-N
LogP
1.34
CAS DataBase Reference
122-59-8(CAS DataBase Reference)
NIST Chemistry Reference
Acetic acid, phenoxy-(122-59-8)
EPA Substance Registry System
Phenoxyacetic acid (122-59-8)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36-37/39
RIDADR 
UN 3345 6.1/ PGIII
WGK Germany 
3
RTECS 
AJ2230000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29189090
Toxicity
LD50 orally in Rabbit: 1500 mg/kg LD50 dermal Rabbit > 5000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
158518
Product name
Phenoxyacetic acid
Purity
98%
Packaging
500g
Price
$81
Updated
2024/03/01
Sigma-Aldrich
Product number
8.00667
Product name
Phenoxyacetic acid
Purity
for synthesis
Packaging
500g
Price
$112
Updated
2022/05/15
Sigma-Aldrich
Product number
34366
Product name
Phenoxyacetic acid
Purity
PESTANAL?, analytical standard
Packaging
100MG
Price
$43.9
Updated
2022/05/15
TCI Chemical
Product number
P0107
Product name
Phenoxyacetic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
P0107
Product name
Phenoxyacetic Acid
Purity
>98.0%(GC)(T)
Packaging
500g
Price
$53
Updated
2024/03/01
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Phenoxyacetic acid Chemical Properties,Usage,Production

Chemical Properties

Phenoxyacetic acid has a sour, sweet odor and a honey-like taste.

Occurrence

Reported found in cocoa beans

Uses

Phenoxyacetic acid is a flavoring ingredient.?Its photodegradation using titanium dioxide as photocatalyst has been studied. Selective separation of penicillin V from phenoxyacetic acid using liquid membranes consisting of 1,2-dichloroethane and Amberlite LA-2 as carrier has been studied.

Uses

Fungicide; keratin exfoliative (to relieve and to soften calluses, corns, and other hard skin surfaces; applied as plasters, pads or in liquids).

Definition

ChEBI: Phenoxyacetic acid is a monocarboxylic acid that is the O-phenyl derivative of glycolic acid. A metabolite of 2-phenoxyethanol, it is used in the manufacture of pharmaceuticals, pesticides, fungicides and dyes. It has a role as a human xenobiotic metabolite, an Aspergillus metabolite, a plant growth retardant and an allergen. It is a monocarboxylic acid and an aromatic ether. It is functionally related to a glycolic acid. It is a conjugate acid of a phenoxyacetate.

Synthesis Reference(s)

Synthetic Communications, 16, p. 479, 1986 DOI: 10.1080/00397918608057726

General Description

Light tan powder or white solid.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

Phenoxyacetic acid reacts exothermically with all bases, both organic (for example, the amines) and inorganic.

Health Hazard

ACUTE/CHRONIC HAZARDS: Phenoxyacetic acid is a mild skin irritant.

Fire Hazard

Flash point data for Phenoxyacetic acid are not available; however Phenoxyacetic acid is probably combustible.

Synthesis

A Schlenk tube was charged with aryl iodides (1) (1.0 mmol), glycolic acid (228 mg, 3.0 mmol), CuI (19.0 mg, 0.1 mmol), Cs2CO3 (1.95 g, 6.0 mmol), and DMSO/H2O (2 mL/1 mL). The mixture was stirred for 24 h at 120 ℃ under Ar. The reaction mixture was allowed to cool to room temperature, poured into 5 mL of water, and then acidified to pH = 1 with 2 N HCl solution. The aqueous phase was extracted twice with EtOAc, and the combined organic layer was washed with H2O and brine, dried over anhydrous MgSO4, and concentrated under vacuum. Purification of the crude product by column chromatography (dichloromethane/methanol) afforded the desired product Phenoxyacetic acid, white solid, yield 133 mg, 88%. 

Purification Methods

Crystallise the acid from water or aqueous EtOH. [Beilstein 6 IV 634.]

Phenoxyacetic acid Preparation Products And Raw materials

Raw materials

Chloroacetic acid Phenol

Preparation Products

Allyl phenoxyacetate 4-(Hydroxymethyl)phenoxyacetic acid ?4-Chlorophenoxyacetic acid sodium salt 4-Chlorophenoxyacetic acid 2,4-Dichlorophenoxyacetic acid Benzofuran 2,4-Dichlorophenoxybutyric acid
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View Lastest Price from Phenoxyacetic acid manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Phenoxyacetic acid 122-59-8
Price
US $65.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-06-06
Hebei Weibang Biotechnology Co., Ltd
Product
Phenoxyacetic acid 122-59-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-22
Ningxia Jinhua Chemical Co.,Ltd
Product
Phenoxyacetic Acid 122-59-8
Price
US $6180.00/T
Min. Order
1T
Purity
99%
Supply Ability
1000 tons/Year
Release date
2021-06-24

122-59-8, Phenoxyacetic acidRelated Search:

Glycolic acid Ethyl phenylacetate Ethyl 2-(Chlorosulfonyl)acetate Fluroxypyr PHENYL VALERATE Ethylbenzene Diphenyl ether Folic acid Stearic acid Phenyl salicylate Citric acid Hyaluronic acid 4-Hydroxyphenylacetic acid 2-Hydroxyphenylacetic acid Triclopyr 4-Chlorophenoxyacetic acid PHENYL RESIN Ascoric Acid Phenoxyacetic

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