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ChemicalBook > CAS DataBase List > 2-BROMO-3-FORMYLPYRIDINE

2-BROMO-3-FORMYLPYRIDINE

Uses
Product Name
2-BROMO-3-FORMYLPYRIDINE
CAS No.
128071-75-0
Chemical Name
2-BROMO-3-FORMYLPYRIDINE
Synonyms
2-BROMONICOTINALDEHYDE;CAS:128071-75-0;2-Bromopyridine-3-ca;2-BROMO-3-FORMYLPYRIDINE;2-Bromonicotinaldehyde 97%;2-Bromonicotinaldehyde >2-broMopyridin-3-carbaldehyde;-Bromopyridine-3-carbaldehyde;2-bromopyridine-3-formaldehyde;2-Bromo-3-pyridinecarbaldehyde
CBNumber
CB3710744
Molecular Formula
C6H4BrNO
Formula Weight
186.01
MOL File
128071-75-0.mol
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2-BROMO-3-FORMYLPYRIDINE Property

Melting point:
73 °C
Boiling point:
100 °C / 3mmHg
Density 
1.683±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
-1.01±0.10(Predicted)
color 
White to Orange to Green
InChI
InChI=1S/C6H4BrNO/c7-6-5(4-9)2-1-3-8-6/h1-4H
InChIKey
GNFWMEFWZWXLIN-UHFFFAOYSA-N
SMILES
C1(Br)=NC=CC=C1C=O
CAS DataBase Reference
128071-75-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36-43
Safety Statements 
26-36/37
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
632147
Product name
2-Bromo-3-pyridinecarboxaldehyde
Purity
96%
Packaging
1g
Price
$26.8
Updated
2025/07/31
Sigma-Aldrich
Product number
632147
Product name
2-Bromo-3-pyridinecarboxaldehyde
Purity
96%
Packaging
5g
Price
$37.62
Updated
2025/07/31
TCI Chemical
Product number
B2625
Product name
2-Bromonicotinaldehyde
Purity
>98.0%(GC)
Packaging
1g
Price
$32
Updated
2025/07/31
TCI Chemical
Product number
B2625
Product name
2-Bromonicotinaldehyde
Purity
>98.0%(GC)
Packaging
5g
Price
$106
Updated
2025/07/31
TRC
Product number
B677835
Product name
2-Bromonicotinaldehyde
Packaging
10mg
Price
$45
Updated
2021/12/16
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2-BROMO-3-FORMYLPYRIDINE Chemical Properties,Usage,Production

Uses

2-Bromo-3-pyridinecarboxaldehyde is a pyridine heterocyclic compound mainly used in laboratory organic synthesis processes.

Chemical Properties

Yellow solid

Synthesis

109-04-6

68-12-2

128071-75-0

To a cooled solution of diisopropylamine (20.4 g, 28.0 mL, 0.202 mol) in anhydrous THF (400 mL) at -78 °C was slowly added n-BuLi (0.192 mol, 58.0 mL, 3.3 M hexane solution). The reaction mixture was stirred at -78 °C for 1 h, followed by the dropwise addition of anhydrous THF (150 mL) solution of 2-bromopyridine (25.3 g, 0.160 mol) over 20 min. After keeping the reaction at -78 °C for 90 min, an anhydrous THF (25 mL) solution of DMF (35.0 g, 0.480 mol) cooled to -78 °C was quickly added. Stirring was continued at -78 °C for 80 min, and upon completion of the reaction, the reaction was quenched with NaH2PO4 (27.6 g, 0.230 mol, dissolved in H2O (120 mL)), slowly warmed to room temperature, and diluted with MeOt-Bu (500 mL). The organic phase was separated, washed with brine (2100 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was ground with pentane and after decantation, the remaining solid was recrystallized from hexane to give 16.7 g of 2-bromo-3-pyridinecarboxaldehyde as a pale yellow solid in 56% yield, melting point 67-69 °C. 1H NMR (400 MHz, CDCl3) δ: 10.35 (s, 1H), 8.57 (dd, J=4.7,2.1 Hz, 1H), 8.17 (dd, J= 7.6,2.1Hz, 1H), 7.44 (dd, J=7.6,4.7,0.6Hz, 1H).13C NMR (101MHz, CDCl3) δ: 190.4,154.0,144.9,137.5,130.1,123.0. Calculated values for elemental analyses (C6H4BrNO): C, 38.74; H. 2.17; N, 7.53; Br, 42.96. Measured values: C, 38.58; H, 2.08; N, 7.57; Br, 42.69.

References

[1] Tetrahedron Letters, 2008, vol. 49, # 17, p. 2839 - 2843
[2] Chemical Communications, 2011, vol. 47, # 23, p. 6635 - 6637
[3] Organic Letters, 2007, vol. 9, # 5, p. 891 - 894
[4] Tetrahedron Letters, 2017, vol. 58, # 20, p. 1989 - 1991
[5] Synthesis (Germany), 2018, vol. 50, # 1, p. 155 - 169

2-BROMO-3-FORMYLPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-BROMO-3-FORMYLPYRIDINE manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-BROMO-3-FORMYLPYRIDINE 128071-75-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-06-03
Henan Aochuang Chemical Co.,Ltd.
Product
2-BROMO-3-FORMYLPYRIDINE 128071-75-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Henan Fengda Chemical Co., Ltd
Product
2-BROMO-3-FORMYLPYRIDINE 128071-75-0
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08

128071-75-0, 2-BROMO-3-FORMYLPYRIDINERelated Search:


  • 2-BROMONICOTINALDEHYDE
  • 2-BROMO-PYRIDINE-3-CARBALDEHYDE
  • 2-BROMOPYRIDINE-3-CARBOXALDEHYDE
  • 2-BROMO-3-FORMYLPYRIDINE
  • 2-BROMO-3-PYRIDINECARBOXALDEHYDE
  • 2-Bromo-3-pyridinecarboxaldehyde ,96%
  • 2-Bromopyridine-3-carboxaldehyde 97%
  • 2-Bromopyridine-3-carboxaldehyde, 2-Bromo-3-formylpyridine
  • 2-Bromo-3-pyridinecarboxaldehyde,2-Bromo-3-formylpyridine
  • 2-Bromonicotinaldehyde 97%
  • 2-bromonicotinaldehyde(SALTDATA: FREE)
  • 2-broMopyridin-3-carbaldehyde
  • 2-Bromo-3-pyridinecarboxaldehyde 96%
  • 2-Bromopyridine-3-ca
  • 2-Bromonicotinaldehyde &gt
  • 3-Pyridinecarboxaldehyde, 2-bromo-
  • 2-BROMO-3-FORMYLPYRIDINE ISO 9001:2015 REACH
  • -Bromopyridine-3-carbaldehyde
  • 2-bromopyridine-3-formaldehyde
  • 2-Bromo-3-pyridinecarbaldehyde
  • CAS:128071-75-0
  • 128071-75-0
  • Halogenated Heterocycles
  • Bromopyridines
  • Halopyridines
  • Pyridines
  • Heterocyclic Building Blocks
  • Building Blocks
  • Heterocycle-Pyridine series
  • Heterocycles
  • Halogenated
  • Organohalides
  • Bromopyridines
  • Halopyridines
  • pharmacetical
  • Aldehydes
  • Pyridines
  • Pyridine
  • Pyridines derivates