2-BROMO-3-FORMYLPYRIDINE
Uses- Product Name
- 2-BROMO-3-FORMYLPYRIDINE
- CAS No.
- 128071-75-0
- Chemical Name
- 2-BROMO-3-FORMYLPYRIDINE
- Synonyms
- 2-BROMONICOTINALDEHYDE;CAS:128071-75-0;2-Bromopyridine-3-ca;2-BROMO-3-FORMYLPYRIDINE;2-Bromonicotinaldehyde 97%;2-Bromonicotinaldehyde >2-broMopyridin-3-carbaldehyde;-Bromopyridine-3-carbaldehyde;2-bromopyridine-3-formaldehyde;2-Bromo-3-pyridinecarbaldehyde
- CBNumber
- CB3710744
- Molecular Formula
- C6H4BrNO
- Formula Weight
- 186.01
- MOL File
- 128071-75-0.mol
2-BROMO-3-FORMYLPYRIDINE Property
- Melting point:
- 73 °C
- Boiling point:
- 100 °C / 3mmHg
- Density
- 1.683±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- -1.01±0.10(Predicted)
- color
- White to Orange to Green
- InChI
- InChI=1S/C6H4BrNO/c7-6-5(4-9)2-1-3-8-6/h1-4H
- InChIKey
- GNFWMEFWZWXLIN-UHFFFAOYSA-N
- SMILES
- C1(Br)=NC=CC=C1C=O
- CAS DataBase Reference
- 128071-75-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 632147
- Product name
- 2-Bromo-3-pyridinecarboxaldehyde
- Purity
- 96%
- Packaging
- 1g
- Price
- $26.8
- Updated
- 2025/07/31
- Product number
- 632147
- Product name
- 2-Bromo-3-pyridinecarboxaldehyde
- Purity
- 96%
- Packaging
- 5g
- Price
- $37.62
- Updated
- 2025/07/31
- Product number
- B2625
- Product name
- 2-Bromonicotinaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $32
- Updated
- 2025/07/31
- Product number
- B2625
- Product name
- 2-Bromonicotinaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $106
- Updated
- 2025/07/31
- Product number
- B677835
- Product name
- 2-Bromonicotinaldehyde
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
2-BROMO-3-FORMYLPYRIDINE Chemical Properties,Usage,Production
Uses
2-Bromo-3-pyridinecarboxaldehyde is a pyridine heterocyclic compound mainly used in laboratory organic synthesis processes.
Chemical Properties
Yellow solid
Synthesis
109-04-6
68-12-2
128071-75-0
To a cooled solution of diisopropylamine (20.4 g, 28.0 mL, 0.202 mol) in anhydrous THF (400 mL) at -78 °C was slowly added n-BuLi (0.192 mol, 58.0 mL, 3.3 M hexane solution). The reaction mixture was stirred at -78 °C for 1 h, followed by the dropwise addition of anhydrous THF (150 mL) solution of 2-bromopyridine (25.3 g, 0.160 mol) over 20 min. After keeping the reaction at -78 °C for 90 min, an anhydrous THF (25 mL) solution of DMF (35.0 g, 0.480 mol) cooled to -78 °C was quickly added. Stirring was continued at -78 °C for 80 min, and upon completion of the reaction, the reaction was quenched with NaH2PO4 (27.6 g, 0.230 mol, dissolved in H2O (120 mL)), slowly warmed to room temperature, and diluted with MeOt-Bu (500 mL). The organic phase was separated, washed with brine (2100 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was ground with pentane and after decantation, the remaining solid was recrystallized from hexane to give 16.7 g of 2-bromo-3-pyridinecarboxaldehyde as a pale yellow solid in 56% yield, melting point 67-69 °C. 1H NMR (400 MHz, CDCl3) δ: 10.35 (s, 1H), 8.57 (dd, J=4.7,2.1 Hz, 1H), 8.17 (dd, J= 7.6,2.1Hz, 1H), 7.44 (dd, J=7.6,4.7,0.6Hz, 1H).13C NMR (101MHz, CDCl3) δ: 190.4,154.0,144.9,137.5,130.1,123.0. Calculated values for elemental analyses (C6H4BrNO): C, 38.74; H. 2.17; N, 7.53; Br, 42.96. Measured values: C, 38.58; H, 2.08; N, 7.57; Br, 42.69.
References
[1] Tetrahedron Letters, 2008, vol. 49, # 17, p. 2839 - 2843
[2] Chemical Communications, 2011, vol. 47, # 23, p. 6635 - 6637
[3] Organic Letters, 2007, vol. 9, # 5, p. 891 - 894
[4] Tetrahedron Letters, 2017, vol. 58, # 20, p. 1989 - 1991
[5] Synthesis (Germany), 2018, vol. 50, # 1, p. 155 - 169
2-BROMO-3-FORMYLPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
2-BROMO-3-FORMYLPYRIDINE Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
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View Lastest Price from 2-BROMO-3-FORMYLPYRIDINE manufacturers
- Product
- 2-BROMO-3-FORMYLPYRIDINE 128071-75-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-03
- Product
- 2-BROMO-3-FORMYLPYRIDINE 128071-75-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- 2-BROMO-3-FORMYLPYRIDINE 128071-75-0
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08