ChemicalBook > CAS DataBase List > Tetraethylene glycol di-p-tosylate

Tetraethylene glycol di-p-tosylate

Product Name: Tetraethylene glycol di-p-tosylate
CAS No.: 37860-51-8
Chemical Name: Tetraethylene glycol di-p-tosylate
Synonyms: ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(4-Methylbenzenesulfonate);TETRAETHYLENE GLYCOL BIS(P-TOLUENESULFONATE);Tos-PEG5-Tos;Bis-Tos-PEG4;TSO-PEG4-OTS;CAS_37860-51-8;PROTAC Linker 16;TosO-(CH2CH2O)4-Tos;TETRAETHYLENE GLYCOL DITOSYLATE;TETRAETHYLENE GLYCOL DI-P-TOSYLATE
CBNumber: CB3727438
Molecular Formula: C22H30O9S2
Formula Weight: 502.6
MOL File: 37860-51-8.mol

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Tetraethylene glycol di-p-tosylate Property

Melting point:: 65-69 °C
Boiling point:: 635.0±55.0 °C(Predicted)
Density: 1.242 g/mL at 25 °C (lit.)
refractive index: n20/D 1.53(lit.)
Flash point:: >230 °F
storage temp.: Sealed in dry,Room Temperature
form: clear liquid
color: colorless to yellow
BRN: 1610992
InChI: InChI=1S/C22H30O9S2/c1-19-3-7-21(8-4-19)32(23,24)30-17-15-28-13-11-27-12-14-29-16-18-31-33(25,26)22-9-5-20(2)6-10-22/h3-10H,11-18H2,1-2H3
InChIKey: SLAONPBUWDUSSO-UHFFFAOYSA-N
SMILES: O(CCOCCOS(C1=CC=C(C)C=C1)(=O)=O)CCOCCOS(C1=CC=C(C)C=C1)(=O)=O
EPA Substance Registry System: Ethanol, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-, bis(4-methylbenzenesulfonate) (37860-51-8)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2909498090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 341703
Product name: Tetraethylene glycol di(p-toluenesulfonate)
Purity: 97%
Packaging: 10g
Price: $115
Updated: 2025/07/31

Sigma-Aldrich

Product number: 341703
Product name: Tetraethylene glycol di(p-toluenesulfonate)
Purity: 97%
Packaging: 50g
Price: $354.2
Updated: 2025/07/31

TCI Chemical

Product number: T1493
Product name: Tetraethylene Glycol Bis(p-toluenesulfonate)
Purity: >98.0%(T)
Packaging: 25g
Price: $148
Updated: 2025/07/31

AK Scientific

Product number: Y4943
Product name: Tetraethylene Glycol Bis(p-toluenesulfonate)
Packaging: 1g
Price: $27
Updated: 2021/12/16

Activate Scientific

Product number: AS41984
Product name: ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate)
Purity: 97+%
Packaging: 5G
Price: $43
Updated: 2021/12/16

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Tetraethylene glycol di-p-tosylate Chemical Properties,Usage,Production

Description

Tos-PEG5-Tos is a PEG linker containing two tosyl groups. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Uses

Tetraethylene glycol di(p-toluenesulfonate), also known as Tetraethylene glycol di-p-tosylate, was used in the preparation of donor-spacer-acceptor podand system, dual channel fluorosensor for Li⁺, Mg²⁺ and Ca²⁺.

Synthesis

112-60-7

98-59-9

37860-51-8

77544-60-6

20.0 g of tetraethylene glycol triacetonitrile and 10.2 g of triethylamine were added to a reaction flask, 300 mL of acetonitrile was added to dissolve the mixture, and the mixture was cooled to 0-5°C in an ice bath. 19.0 g of p-toluenesulfonyl chloride was dissolved in 100 mL of acetonitrile and slowly added dropwise to the reaction mixture, the dropwise addition time was controlled at 1 hour. After the dropwise addition was completed, the temperature of the reaction mixture was raised to 20-25 °C and the reaction was continued for 12 hours. After completion of the reaction, the solvent was removed by rotary evaporation. The crude product was separated by column chromatography using gradient elution with hexane:ethyl acetate (v/v=4:1) and hexane:ethyl acetate (v/v=1.5:1). In the eluate of hexane:ethyl acetate (v/v=4:1), 12.9 g of oily product (tetraethylene glycol di-p-toluenesulfonate) was obtained in 35.9% yield. In the eluate of hexane:ethyl acetate (v/v=1.5:1), 5.4 g of oily product (tetraethyleneglycol mono-p-toluenesulfonate) was obtained in 10.4% yield.

IC 50

PEGs

storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year;

References

[1] Organic Letters, 2002, vol. 4, # 14, p. 2329 - 2332
[2] Journal of Organic Chemistry USSR (English Translation), 1990, vol. 26, # 11, p. 2094 - 2100
[3] Zhurnal Organicheskoi Khimii, 1990, vol. 26, # 11, p. 2425 - 2433
[4] Patent: CN105541736, 2016, A. Location in patent: Paragraph 0044; 0052
[5] Journal of the Chemical Society, Perkin Transactions 2, 2001, # 9, p. 1573 - 1584

Tetraethylene glycol di-p-tosylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Tetraethylene glycol di-p-tosylate manufacturers

XIAMEN SINOPEG BIOTECH CO., LTD.

Product: 1,11-Bis(tosyloxy)-3,6,9-trioxaundecane 37860-51-8
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
Release date: 2025-09-10

Xian confluore Biological Technology Co., Ltd.

Product: Tos-PEG5-Tos 37860-51-8
Price: US $0.00/g
Min. Order: 500g
Purity: >98.00%
Supply Ability: 500g
Release date: 2024-03-27

37860-51-8, Tetraethylene glycol di-p-tosylateRelated Search:

Tetraethylene glycol p-toluenesulfonate m-PEG5-Tos TETRAETHYL METHYLENEDIPHOSPHONATE Tetraethylene glycol dimethacrylate TETRAETHYLENEGLYCOL MONOMETHYL ETHER Tetraethyleneglycol monooctyl ether Tos-PEG13-Tos Tos-PEG10-CH2CH2COOtBu Tos-PEG21-Tos Tos-PEG6-t-Butyl ester Tos-PEG3-CH2CO2tBu Tos-PEG13-t-butyl ester Tos-PEG5-CH2CO2t-butyl ester Tos-PEG9-t-butyl ester Tos-PEG7-t-butyl ester Tos-PEG4-t-butyl ester (2-{2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-acetic acid tert-butyl ester Tos-PEG7-CH2CO2t-butyl ester

BIS[2-(2-TOSYLOXYETHOXY)ETHYL] ETHER

BIS[2-[2-(P-TOLUENESULFONYLOXY)ETHOXY]ETHYL] ETHER

TETRAETHYLENE GLYCOL BIS(P-TOLUENESULFONATE)

TETRAETHYLENE GLYCOL DI-P-TOSYLATE

TETRAETHYLENE GLYCOL DITOSYLATE

Tetraethylene glycol di(p-toluenesulfonate)

DRAFT CHECKER, AIRFLOW DETECTION POWDER

1,11-Bis(tosyloxy)-3,6,9-trioxaundecane

2,2'-[Oxybis(ethyleneoxy)]diethanol bis(p-toluenesulfonate)

Bis(4-methylbenzenesulfonic acid)[oxybis(ethyleneoxyethylene)] ester

Bis(4-methylbenzenesulfonic acid)3,6,9-trioxa-1,11-undecanediyl ester

Bis(p-toluenesulfonic acid)oxybisethylenebisoxybisethylene ester

2,2'-(Ethylenedioxy)triethyl ditosylate

Bis[2-[2-(p-toluenesulfonyloxy)ethoxy]ethyl] Ether Bis[2-(2-tosyloxyethoxy)ethyl] Ether Tetraethylene Glycol Di-p-tosylate

2,2'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))bis(ethane-2,1-diyl) bis(4-Methylbenzenesulfonate)

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(4-Methylbenzenesulfonate)

Tos-PEG5-Tos

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane...

Tetraethylene Glycol Bis(<i>p</i>-toluenesulfonate)

PROTAC Linker 16

CAS_37860-51-8

Bis-Tos-PEG4

Ethanol, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-, 1,1'-bis(4-methylbenzenesulfonate)

Tetraethyleneglycol-di-p-toluenesulphonate

2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate

TosO-(CH2CH2O)4-Tos

etraethylene glycol di(p-toluenesulfonate)

Tos-PEG4-Tos/Ethanol, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-, 1,1'-bis(4-methylbenzenesulfonate)

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate) , Bis-Tos-PEG4

Tetraethylene glycol di(<i>p</i>-toluenesulfonate)

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfote)

TSO-PEG4-OTS

37860-51-8

C22H30O9S

C22H30O9S2

CH3C6H4SO3CH2CH2OCH2CH22O

Organic Building Blocks

Sulfur Compounds

Tosylates

Building Blocks