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CHELERYTHRINE CHLORIDE

Product Name
CHELERYTHRINE CHLORIDE
CAS No.
3895-92-9
Chemical Name
CHELERYTHRINE CHLORIDE
Synonyms
1,2-diMethoxy-12-Methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-iuM chloride;TODDALIN;CHELERYTHRIN CL;Chelerythrine Cl;TODDALIN CHLORIDE;CHELERYTHRIN CHLORIDE;Chelerythrine cloride;Chelerythrine chloride;CHELERYTHRINE CHLORIDE(P);Chelerythrine chloride-RM
CBNumber
CB3760820
Molecular Formula
C21H18ClNO4
Formula Weight
383.82
MOL File
3895-92-9.mol
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CHELERYTHRINE CHLORIDE Property

Melting point:
195-205 °C
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO: ≥10 mg/mL
form 
powder
color 
yellow to orange
Water Solubility 
water: 1mg/mL
DMSO: 10mg/mL
Stability:
Hygroscopic
InChIKey
WEEFNMFMNMASJY-UHFFFAOYSA-M
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38-36/37
Safety Statements 
26-36-36/37
RIDADR 
UN 1544PSN1 6.1 / PGII
WGK Germany 
3
RTECS 
FL9200000
HS Code 
29349990
Toxicity
mouse,LD50,intravenous,18500ug/kg (18.5mg/kg),Planta Medica. Vol. 43, Pg. 161, 1981.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0002288
Product name
Chelerythrine chloride
Purity
CRS, European Pharmacopoeia (EP) Reference Standard
Packaging
Y0002288
Price
$152
Updated
2024/03/01
Sigma-Aldrich
Product number
C2932
Product name
Chelerythrine chloride
Purity
≥95% (TLC), powder
Packaging
1mg
Price
$66.8
Updated
2024/03/01
Sigma-Aldrich
Product number
220285
Product name
Chelerythrine Chloride
Purity
Naturally-occurring alkaloid.
Packaging
5mg
Price
$187
Updated
2024/03/01
Alfa Aesar
Product number
J62906
Product name
Chelerythrine chloride, 99+%
Packaging
5mg
Price
$130.65
Updated
2024/03/01
Alfa Aesar
Product number
J62906
Product name
Chelerythrine chloride, 99+%
Packaging
10mg
Price
$200.65
Updated
2024/03/01
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CHELERYTHRINE CHLORIDE Chemical Properties,Usage,Production

Description

Chelerythrine is a potent, cell permeable inhibitor of protein kinase C (IC50 = 660 nM) that does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase, or calcium/calmodulin-dependent protein kinase. Chelerythrine also inhibits Bcl-xL function (IC50 = 1.5 μM) by displacing Bax binding, inducing apoptosis in several cancer cell lines. Chelerythrine can also have PKC-independent effects, activate p38 MAP kinase and JUNK signaling pathways, and induce apoptosis in cancer cells both in vitro and in vivo.

Chemical Properties

yellow to orange solid

Uses

Chelerythrine Chloride is a cell permeable protein kinase C (PKC) inhibitor.

General Description

Naturally occurring alkaloid. Cell-permeable, selective inhibitor of protein kinase C (IC50 = 660 nM). Acts on the catalytic domain irrespective of the attachment of the regulatory domain. Material is a competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells.

Biochem/physiol Actions

Cell permeable: yes

storage

-20°C (desiccate)

References

1. j. m. herbert, j. m. augereau, j. gleye and j. p. maffrand, biochem biophys res commun 1990, 172, 993-999. 2. w. d. jarvis, a. j. turner, l. f. povirk, r. s. traylor and s. grant, cancer res 1994, 54, 1707-1714. 3. j. vrba, p. dolezel, j. vicar, m. modriansky and j. ulrichova, toxicol in vitro 2008, 22, 1008-1017. 4. m. vogler, k. weber, d. dinsdale, i. schmitz, k. schulze-osthoff, m. j. dyer and g. m. cohen, cell death differ 2009, 16, 1030-1039. 5. r. yu, s. mandlekar, t. h. tan and a. n. kong, j biol chem 2000, 275, 9612-9619. 6. s. yamamoto, k. seta, c. morisco, s. f. vatner and j. sadoshima, j mol cell cardiol 2001, 33, 1829-1848.

CHELERYTHRINE CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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CHELERYTHRINE CHLORIDE Suppliers

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View Lastest Price from CHELERYTHRINE CHLORIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
CHELERYTHRINE CHLORIDE 3895-92-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-08-15
Career Henan Chemical Co
Product
CHELERYTHRINE CHLORIDE 3895-92-9
Price
US $1.00/kg
Min. Order
1 mg
Purity
99%
Supply Ability
100KG
Release date
2018-12-25

3895-92-9, CHELERYTHRINE CHLORIDERelated Search:

GF109203X GO 6976 D-ERYTHRO-SPHINGOSINE GANGLIOSIDE GD1A DISODIUM SALT BISINDOLYLMALEIMIDE II BISINDOLYLMALEIMIDE VII 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether Chloromethane Chrysene Chelerythrine 2,3-Dihydroxynaphthalene 8-Isoquinolinol 7-Hydroxyisoquinoline Phenanthridine CHELERYTHRINE CHLORIDE 7,8-BENZOQUINOLINE 7-METHOXY-ISOQUINOLINE 8-Methoxyisoquinoline

  • TODDALIN
  • TODDALIN CHLORIDE
  • 3)benzodioxolo(5,6-c)phenanthridinium,1,2-dimethoxy-12-methyl-(chloride
  • chelerythrinehydrochloride
  • 1,2-DIMETHOXY-12,[1,3]-BENZODIOXOLO[5,6-C]PHENANTHRIDINIUM CHLORIDE
  • 1,2-DIMETHOXY-12-METHYL[1,3]BENZODIOXOLO[5,6-C]PHENANTHRIDINIUM CHLORIDE
  • CHELERYTHRIN CHLORIDE
  • CHELERYTHRIN CL
  • Chelerythrine cloride
  • [1,3]Benzodioxolo[5,6-c]phenanthridinium, 1,2-dimethoxy-12-methyl-, chloride (1:1)
  • CHELERYTHRINE CHLORIDE(RG)
  • Chelerythrine Chloride - CAS 3895-92-9 - Calbiochem
  • Chelerythrine chloride,98%
  • Chelerythrine chloride1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride
  • Chelerythrine chloride
  • 1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride
  • [1,3]Benzodioxolo[5,6-c]phenanthridiniuM, 1,2-diMethoxy-12-Methyl-, chloride
  • CHELERYTHRINE CHLORIDE(P)
  • 1,2-diMethoxy-12-Methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-iuM chloride
  • Chelerythrine Cl
  • 17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyclo[11.8.0.02,1.0,.01,1]henicosa-1(13),2,4(8),9,11,14,16,18,20-nonaen-21-ium chloride
  • CHELERYTHRINE CHLORIDE(RG) 5mg
  • Chelerythrine chloride-RM
  • Chelerythrine chloride 100 μg/ml Acetonitrile
  • Chelerythrine chloride, Cell-permeable protein kinase C inhibitor
  • Chelerythrine chloride, 10 mM in DMSO
  • 3895-92-9
  • 16732-75-2
  • C21H18ClNO4
  • C12H18NO4
  • C21H18NO4Cl
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Kinase/Phosphatase Biology
  • Protein Kinase C (PKC)
  • Serine/Threonine Kinase Inhibitors
  • antibiotic
  • Herb extract
  • Alkaloids
  • Protein Kinase