platyphylline
- Product Name
- platyphylline
- CAS No.
- 480-78-4
- Chemical Name
- platyphylline
- Synonyms
- Platifillin;Platiphyllin;Platiphillin;Platyphyllin;platyphylline;Einecs 207-558-6;66641-38-1 (Hydrochloride);PLATYPHYLLINI HYDROTARTRAS;12-Hydroxy-1,2-dihydrosenecionan-11,16-dione;(1R)-1,2-Dihydro-12-hydroxysenecionan-11,16-dione
- CBNumber
- CB3914285
- Molecular Formula
- C18H27NO5
- Formula Weight
- 337.41
- MOL File
- 480-78-4.mol
platyphylline Property
- Melting point:
- 129°
- alpha
- D20 -56.4° (c = 0.7 in chloroform)
- Boiling point:
- 539.6±50.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- pka
- 12.83±0.40(Predicted)
Safety
- RIDADR
- 1544
- HazardClass
- 6.1(b)
- PackingGroup
- III
N-Bromosuccinimide Price
- Product number
- 059765
- Product name
- 12-Hydroxy-1,2-dihydrosenecionan-11,16-dione
- Packaging
- 500mg
- Price
- $199
- Updated
- 2021/12/16
- Product number
- API0016155
- Product name
- PLATYPHYLLINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $232.05
- Updated
- 2021/12/16
- Product number
- 059765
- Product name
- 12-Hydroxy-1,2-dihydrosenecionan-11,16-dione
- Packaging
- 1g
- Price
- $306
- Updated
- 2021/12/16
- Product number
- 059765
- Product name
- 12-Hydroxy-1,2-dihydrosenecionan-11,16-dione
- Packaging
- 5g
- Price
- $1071
- Updated
- 2021/12/16
- Product number
- CFN00403
- Product name
- Platyphylline
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $468
- Updated
- 2021/12/16
platyphylline Chemical Properties,Usage,Production
Description
A hepatotoxic alkaloid, the base has been isolated from Senecio adnatus D.C., S. hygrophilus Dyer & Sm. and S. piatyphyllus D.C. The alkaloid is only sparingly soluble in petroleum ether or hot H20, more so in Me2CO, EtOH, C6H6 or Et20 and readily soluble in CHCI3. It is laevorotatory with [α]D - 45.09° (CHCI3). The perchlorate occurs as colourless prisms from H20, m.p. 222-3°C (dec.); the picrolonate, dark yellow needles, m.p. 205-6°C (dec.); aurichloride, m.p. 200-loC (dec.) and the methiodide, m.p. 216-7°C; [α]D - 31.27° (EtOH). The alkaloid contains one hydroxyl group but no methoxyl or methylimino groups. On hydrolysis it furnishes platynecine, CSH1S0 2N, m.p. 148°C; [α]D - 56.8° (CHCI3) and platynecic acid, ClOH140 4 , m.p. l54-5°C which is identical with senecic acid lactone.
Uses
12-Hydroxy-1,2-dihydrosenecionan-11,16-dione is a pyrrolizidine alkaloid which can be found in various Senecio species. It can be useful in the generation and characterization of monoclonal antibodies against the pyrrolizidine alkaloid retrorsine .
Definition
ChEBI: Platyphylline is a macrolide.
References
Orekhov, Tiedebel., Ber., 68,653 (1935)
Orekhov, Konovalova, Tiedebel., ibid, 68, 1886 (1935)
Orekhov, Tiedebel., J. Gen. Chern. USSR, 8,273 (1938)
de Waal., Onderstepoort J., 15,251 (1940)
Koekemoer, Warren., J. Chern. Soc., 63 (1955)
platyphylline Preparation Products And Raw materials
Raw materials
Preparation Products
platyphylline Suppliers
- Tel
- 888-539-0666
- Fax
- 888-539-0666
- info@emmx.com
- Country
- United States
- ProdList
- 8449
- Advantage
- 60
- Tel
- +1-781-999-5354
- support@targetmol.com
- Country
- United States
- ProdList
- 19973
- Advantage
- 58