ChemicalBook > CAS DataBase List > Triethyl orthoformate

Triethyl orthoformate

Product Name
Triethyl orthoformate
CAS No.
122-51-0
Chemical Name
Triethyl orthoformate
Synonyms
TRIETHOXYMETHANE;TEOF;ETHYL ORTHOFORMATE;orthoformate;ORTHOFORMIC ACID TRIETHYL ESTER;ETHONE;iethyl orthoforMate;1,1';TEOE;AETHON
CBNumber
CB4126252
Molecular Formula
C7H16O3
Formula Weight
148.2
MOL File
122-51-0.mol
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Triethyl orthoformate Property

Melting point:
-76 °C (lit.)
Boiling point:
146 °C (lit.)
Density 
0.891 g/mL at 25 °C (lit.)
vapor density 
5.11 (vs air)
vapor pressure 
2.9 mm Hg ( 20 °C)
refractive index 
n20/D 1.391(lit.)
Flash point:
86 °F
storage temp. 
Flammables area
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
Liquid
color 
Clear colorless
Water Solubility 
1.35 g/L
Sensitive 
Moisture Sensitive
Merck 
14,6884
BRN 
605384
Stability:
Moisture Sensitive
InChIKey
GKASDNZWUGIAMG-UHFFFAOYSA-N
LogP
1.2 at 20℃
CAS DataBase Reference
122-51-0(CAS DataBase Reference)
NIST Chemistry Reference
Ethyl orthoformate(122-51-0)
EPA Substance Registry System
Ethyl orthoformate (122-51-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
10-36-36/38
Safety Statements 
16-26-37/39-36-45-36/39
RIDADR 
UN 2524 3/PG 3
WGK Germany 
1
RTECS 
RM6475000
F 
21
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29159080
Toxicity
LD50 orally in rats: 7.06 g/kg (Smyth)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T60453
Product name
Triethyl orthoformate
Purity
reagent grade, 98%
Packaging
18L
Price
$1040
Updated
2024/03/01
Sigma-Aldrich
Product number
304050
Product name
Triethyl orthoformate
Purity
anhydrous, 98%
Packaging
2l
Price
$262.2
Updated
2024/03/01
Sigma-Aldrich
Product number
304050
Product name
Triethyl orthoformate
Purity
anhydrous, 98%
Packaging
1l
Price
$297
Updated
2024/03/01
TCI Chemical
Product number
O0066
Product name
Triethyl Orthoformate
Purity
>98.0%(GC)
Packaging
25mL
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
O0066
Product name
Triethyl Orthoformate
Purity
>98.0%(GC)
Packaging
500mL
Price
$46
Updated
2024/03/01
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Triethyl orthoformate Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid; pungent odor. Highly flammable. Slightly soluble in water; soluble in alcohol, ether; decomposes in water.

Uses

Triethyl orthoformate is used in Bodroux-Chichibabin aldehyde synthesis to prepare an aldehyde with one carbon higher by reacting with Grignard reagent. It is also used in the electrophilic formylation of activated aromatic species such as phenol.

Application

Sweet, somewhat camphoraceous-herbaceous odor with a Fimecdle-like note. Triethyl orthoformate has been suggested for use in industrial fragrances for masking, etc. and may find some application in that field. It tends to lift the odor of the conventional components of a pine fragrance and increase the radiation, an effect often desirable for masking purposes.

General Description

Triethyl orthoformate is a clear, colorless liquid with a pungent odor. Less dense than water. Flash point 86°F. Vapors heavier than air. May irritate skin and eyes. Used to make other chemicals.

Reactivity Profile

Triethyl orthoformate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Health Hazard

Triethyl orthoformate may cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Triethyl orthoformate will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Flammability and Explosibility

Flammable

Safety Profile

Moderately toxic by ingestion. Mddly toxic by inhalation, skin contact, and subcutaneous routes. A skin and eye irritant. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidzing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.

Purification Methods

Fractionate triethyl orthoformate first at atmospheric pressure, then in a vacuum. If impure, then shake it with aqueous 2% NaOH, dry it with solid KOH and distil it from sodium through a 20cm Vigreux column (p 11). Alternatively, wash it with H2O, dry it over anhydrous K2CO3, filter and fractionate it through a Widmer column. [Sah & Ma J Am Chem Soc 54 2964 1932, Ohme & Schmitz Justus Liebigs Ann Chem 716 207 1968, Beilstein 2 IV 25.] IRRITANT and FLAMMABLE.

Triethyl orthoformate Preparation Products And Raw materials

Raw materials

Ethanol Sodium Chloroform Sodium ethoxide Sodium ethylate solution,in ethyl alcohol Benzoyl chloride

Preparation Products

5-CARBETHOXYURACIL Ethyl 2-hydroxy-4-methyl-5-pyrimidinecarboxylate 2-AMINO-6-CHLORO-3,5-DICYANOPYRIDINE ETHYL 2-HYDROXY-4-PHENYLPYRIMIDINE-5-CARBOXYLATE 4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER Chloromethyltriethoxysilane 4(3H)-Pyrimidinone, 5-methyl-2-(methylthio)- 1-CHLORO-4-ISOCYANOBENZENE 3-(1,3,4-OXADIAZOL-2-YL)PYRIDINE 1-CYCLOHEXYLURACIL METHYL 5-AMINOISOXAZOLE-4-CARBOXYLATE 2,4-DIAMINOPYRIMIDINE-5-CARBOXYLIC ACID 2-AMINO-3,5-DICYANOPYRIDINE Ethyl 4-amino-2-(ethylthio)-5-pyrimidinecarboxylate 2,4-DIAMINOPYRIMIDINE-5-CARBONITRILE 4-Methylpyrimidine 3-(2-FLUOROBENZYL)THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE 4-Chloro-7-(trifluoromethyl)quinoline 3-Aminopyrazole-4-carboxylic acid ETHYL 2-(ETHYLTHIO)-4-HYDROXYPYRIMIDINE-5-CARBOXYLATE 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE 4,5-Dicyanoimidazole ETHYL(Z)-2-CYANO-3-ETHOXY-2-PROPENOATE Ethoxylated 1-Cyclohexyl-1,2,3,4-tetrahydro-2,4-dioxopyrimidine-5-carbonitrile ,97% ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 4-AMINO-2-(ETHYLTHIO)-5-(HYDROXYMETHYL)PYRIMIDINE ETHYL 4-CHLORO-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLATE N-FORMYLGLYCINE ETHYL ESTER 1-(4-METHYL-2-(METHYLTHIO)PYRIMIDIN-5-YL)ETHANONE 4-HYDROXY-5,7-BIS-TRIFLUOROMETHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 2-HYDROXY-4-METHYLPYRIMIDINE-5-CARBOXYLIC ACID 4-Acetylphenylboronic acid 2-Formylfuran-5-boronic acid Diethoxymethyl acetate Estazolam 5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE 2-HYDROXY-4-PHENYLPYRIMIDINE-5-CARBOXYLIC ACID 5-AMINO-1-PHENYLPYRAZOLE-4-CARBONITRILE
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View Lastest Price from Triethyl orthoformate manufacturers

Ningxia Jinhua Chemical Co.,Ltd
Product
Triethyl Orthoformate 122-51-0
Price
US $0.00/Kg/Drum
Min. Order
180KG
Purity
99.4
Supply Ability
1000kg
Release date
2021-05-17
Hebei Weibang Biotechnology Co., Ltd
Product
Triethyl Orthoformate 122-51-0
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-10-31
Hebei Chuanghai Biotechnology Co,.LTD
Product
Triethyl orthoformate 122-51-0
Price
US $15.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-22

122-51-0, Triethyl orthoformateRelated Search:

Ethyl acetate Benzocaine Ethyl formate Ethanol Triethyl phosphate 2-Ethoxyethanol Ethylparaben Trinexapac-ethyl ISOXADIFEN-ETHYL Urethane Triethylamine Diethyl azodicarboxylate 2,2,2-Trichloroethyl chloroformate Diethyl phthalate Triisopropyl orthoformate Trimethoxymethane Trimethyl orthoacetate Trimethyl orthobenzoate

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