ChemicalBook > CAS DataBase List > CAY10603

CAY10603

Product Name
CAY10603
CAS No.
1045792-66-2
Chemical Name
CAY10603
Synonyms
Isox;187257;BML-281;CAY10603;HDAC6 Inhibitor;CAY10603 CAY10603;HDAC6 inhibitor ISOX;CAY10603; CAY-10603; CAY 10603.;Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem;tert-butyl 4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenylcarbamate
CBNumber
CB42590439
Molecular Formula
C22H30N4O6
Formula Weight
446.5
MOL File
1045792-66-2.mol
More
Less

CAY10603 Property

Density 
1.231±0.06 g/cm3(Predicted)
storage temp. 
+2C to +8C
solubility 
≥22.35 mg/mL in DMSO; insoluble in EtOH; ≥24.85 mg/mL in H2O
form 
Beige to light brown solid
pka
9.47±0.20(Predicted)
color 
White to light yellow
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
13146
Product name
CAY10603
Purity
≥95%
Packaging
1mg
Price
$48
Updated
2024/03/01
Cayman Chemical
Product number
13146
Product name
CAY10603
Purity
≥95%
Packaging
5mg
Price
$176
Updated
2024/03/01
Cayman Chemical
Product number
13146
Product name
CAY10603
Purity
≥95%
Packaging
10mg
Price
$324
Updated
2024/03/01
Cayman Chemical
Product number
13146
Product name
CAY10603
Purity
≥95%
Packaging
25mg
Price
$578
Updated
2024/03/01
TRC
Product number
H999763
Product name
HDAC6Inhibitor
Packaging
500μg
Price
$55
Updated
2021/12/16
More
Less

CAY10603 Chemical Properties,Usage,Production

Description

Histone deacetylase 6 (HDAC6) is a class II HDAC that represses transcription by removing acetyl groups from histones. In addition, HDAC6 deacetylases tubulin, which is important in regulating microtubule stability and function. CAY10603 is a potent and selective inhibitor of HDAC6 (IC50 = 0.002 nM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively). Also, CAY10603 prevents the growth of several pancreatic cancer cell lines (IC50 = 0.1-1 μM). The HDAC6 inhibitor is more active in inhibiting cell growth than the broad spectrum HDAC inhibitor suberoylanilide hydroxamic acid (SAHA).

Uses

HDAC6 Inhibitor is an inhibitor of HDAC6.

Definition

ChEBI: N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl ester is a carbamate ester.

General Description

A cell-permeable, active site Zn2+-targeting phenylisoxazolo-hydroxamate that acts a potent and highly selective HDAC6 inhibitor (IC50 = 0.002, 0.42, 90.7, 252, 271 and 6851 nM against HDAC-6, -3, -10, -2, -1 and -8, respectively). Shown to be more potent than SAHA in inhibiting the proliferation of a panel of pancreatic cancer cell lines (IC50<1.0 μM).

CAY10603 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

CAY10603 Suppliers

China 69 India 1 The Netherlands 1 United States 15 Global 86
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Axon Medchem LLC
Tel
--
Fax
--
Email
info@axonmedchem.com
Country
United States
ProdList
763
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Exlcusive Chemistry Ltd
Tel
--
Fax
--
Country
United States
ProdList
446
Advantage
71
Selleck Chemicals LLC
Tel
--
Fax
--
Email
info@selleckchem.com
Country
United States
ProdList
824
Advantage
60
Santa Cruz Biotechnology, Inc.
Tel
--
Fax
--
Email
scbt@scbt.com
Country
United States
ProdList
3597
Advantage
60

1045792-66-2, CAY10603Related Search:

CarbaMic acid, N-(4-broMo-2-nitrophenyl)-, 1,1-diMethylethyl ester tert-butyl (4-chloro-3-fluoro-2-iodophenyl)carbamate tert-butyl (4-(phenylsulfonyl)benzyl)carbamate Sodium Butyrate Suberohydroxamic acid 1H-Benz[de]isoquinoline-2(3H)-butanamide SCRIPTAID SPLITOMICIN Sodium 4-phenylbutyrate BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE APICIDIN OXAMFLATIN HC TOXIN M344 Parthenolide ACY-1215 Imatinib Nexturastat A

  • CAY10603
  • Isox
  • tert-butyl 4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenylcarbamate
  • HDAC6 Inhibitor
  • N-[4-[3-[[[7-(Hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]carbamic acid 1,1-dimethylethyl ester
  • Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem
  • CAY10603; CAY-10603; CAY 10603.
  • 187257
  • HDAC6 inhibitor ISOX
  • tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxoheptyl]carbamoyl]-1,2-oxazol-5-yl]phenyl]carbamate
  • BML-281
  • Carbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester
  • BML 281,inhibit,Histone deacetylases,BML281,CAY-10603,Inhibitor,CAY10603,CAY 10603,HDAC
  • CAY10603 CAY10603
  • 1045792-66-2
  • Inhibitors