ChemicalBook > CAS DataBase List > PF 04995274

PF 04995274

Product Name
PF 04995274
CAS No.
1331782-27-4
Chemical Name
PF 04995274
Synonyms
PF 04995274;PF04995274;PF 04995274;PF-04995274 >=98% (HPLC);4-[[4-[[4-[(3R)-oxolan-3-yl]oxy-1,2-benzoxazol-3-yl]oxymethyl]piperidin-1-yl]methyl]oxan-4-ol;(R)-4-((4-(((4-((Tetrahydrofuran-3-yl)oxy)benzo[d]isoxazol-3-yl)oxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol;2H-Pyran-4-ol, tetrahydro-4-[[4-[[[4-[[(3R)-tetrahydro-3-furanyl]oxy]-1,2-benzisoxazol-3-yl]oxy]methyl]-1-piperidinyl]methyl]-;Inhibitor,5-HT4,5-hydroxytryptamine Receptor,behavior,Alzheimer′s disease,PF-04995274,inhibit,PF04995274,Serotonin Receptor,5-HT Receptor,Stress-induced,PF 04995274,depressive-like
CBNumber
CB42668576
Molecular Formula
C23H32N2O6
Formula Weight
432.51
MOL File
1331782-27-4.mol
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PF 04995274 Property

storage temp. 
Store at -20°C
solubility 
DMSO:20.0(Max Conc. mg/mL);46.2(Max Conc. mM)
form 
A crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28776
Product name
PF-04995274
Packaging
5mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
28776
Product name
PF-04995274
Packaging
25mg
Price
$412
Updated
2024/03/01
Cayman Chemical
Product number
28776
Product name
PF-04995274
Packaging
1mg
Price
$34
Updated
2024/03/01
Cayman Chemical
Product number
28776
Product name
PF-04995274
Packaging
10mg
Price
$183
Updated
2024/03/01
ChemScene
Product number
CS-0007316
Product name
PF-04995274
Purity
99.42%
Packaging
25mg
Price
$250
Updated
2021/12/16
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PF 04995274 Chemical Properties,Usage,Production

Description

PF-04995274 is a partial agonist of the serotonin (5-HT) receptor subtypes 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E (Kis = 0.36, 0.46, 0.15, and 0.32 nM, respectively, in a radioligand binding assay). It increases cAMP levels in HEK293 cells expressing 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (EC50s = 0.47, 0.36, 0.37, and 0.26 nM, respectively, for the human recombinant receptors). PF-04995274 decreases scopolamine-induced increases in the distance traveled in the Morris water maze in rats when administered at a dose of 0.032 mg/kg.

PF 04995274 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF 04995274 Suppliers

China 33 United States 3 USA 1 Global 37
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1331782-27-4, PF 04995274Related Search:

PF-06282999 PF 4618433 PF-06650833 PF-6260933 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- PF-01247324 PNU 100480 PF 05175157 PF-06882961 PF-5190457 PF-05212384 [(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate PF-04691502 PF 477736 PF-06700841-TsOH PF 573228 PF-3084014 PF 3644022

  • PF 04995274
  • 4-[[4-[[4-[(3R)-oxolan-3-yl]oxy-1,2-benzoxazol-3-yl]oxymethyl]piperidin-1-yl]methyl]oxan-4-ol
  • PF04995274;PF 04995274
  • 2H-Pyran-4-ol, tetrahydro-4-[[4-[[[4-[[(3R)-tetrahydro-3-furanyl]oxy]-1,2-benzisoxazol-3-yl]oxy]methyl]-1-piperidinyl]methyl]-
  • PF-04995274 >=98% (HPLC)
  • Inhibitor,5-HT4,5-hydroxytryptamine Receptor,behavior,Alzheimer′s disease,PF-04995274,inhibit,PF04995274,Serotonin Receptor,5-HT Receptor,Stress-induced,PF 04995274,depressive-like
  • (R)-4-((4-(((4-((Tetrahydrofuran-3-yl)oxy)benzo[d]isoxazol-3-yl)oxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol
  • 1331782-27-4