ChemicalBook > CAS DataBase List > 4-CHLORO-2-METHYLQUINOLINE

4-CHLORO-2-METHYLQUINOLINE

Product Name: 4-CHLORO-2-METHYLQUINOLINE
CAS No.: 4295-06-1
Chemical Name: 4-CHLORO-2-METHYLQUINOLINE
Synonyms: AKOS BBS-00000956;4-CHLOROQUINALDINE;TIMTEC-BB SBB005362;Quinaldine, 4-chloro-;4-Chloroquinaldine 99%;4-CHLORO-2-METHYLQUINOLINE;2-Methyl-4-chloroquinoline;4-Chloro-2-methylquinoline>Quinoline, 4-chloro-2-methyl-;JR-8354, 4-Chloroquinaldine, 97%
CBNumber: CB4286158
Molecular Formula: C10H8ClN
Formula Weight: 177.63
MOL File: 4295-06-1.mol

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4-CHLORO-2-METHYLQUINOLINE Property

Melting point:: 39 °C
Boiling point:: 269-270 °C (lit.)
Density: 0.881 g/mL at 25 °C (lit.)
refractive index: n20/D 1.622(lit.)
Flash point:: >230 °F
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder to lump to clear liquid
pka: 4.40±0.50(Predicted)
color: White or Colorless to Yellow
Water Solubility: Slightly soluble in water.
BRN: 3522
InChI: InChI=1S/C10H8ClN/c1-7-6-9(11)8-4-2-3-5-10(8)12-7/h2-6H,1H3
InChIKey: HQAIROMRVBVWSK-UHFFFAOYSA-N
SMILES: N1C2C(=CC=CC=2)C(Cl)=CC=1C
CAS DataBase Reference: 4295-06-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 150231
Product name: 4-Chloroquinaldine
Purity: 99%
Packaging: 5g
Price: $118
Updated: 2023/01/07

Sigma-Aldrich

Product number: 150231
Product name: 4-Chloroquinaldine
Purity: 99%
Packaging: 25g
Price: $565
Updated: 2023/01/07

TCI Chemical

Product number: C2901
Product name: 4-Chloro-2-methylquinoline
Purity: >98.0%(GC)
Packaging: 5g
Price: $162
Updated: 2025/07/31

TRC

Product number: C895623
Product name: 4-Chloroquinaldine
Packaging: 250mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC75575
Product name: 4-Chloro-2-methylquinoline
Packaging: 1g
Price: $65
Updated: 2021/12/16

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4-CHLORO-2-METHYLQUINOLINE Chemical Properties,Usage,Production

Chemical Properties

Melting point 42-43℃, boiling point 269-270℃, 83℃ (93Pa), relative density 0.881, refractive index 1.6224. Slightly soluble in water.

Uses

4-Chloroquinaldine is used in the preparation of 4-phenyl-hydrazinoquinaldine

Synthesis

607-67-0

4295-06-1

General procedure: 4-hydroxy-2-methylquinoline (5a-c) was added to POCl3 and the reaction mixture was heated to reflux for 12 hours. Upon completion of the reaction, the excess POCl3 was removed by distillation under reduced pressure. the residue was washed once and twice each with CHCl3 and toluene sequentially. The solid obtained was dissolved in CH2Cl2 and triethylamine was added dropwise until the pH of the aqueous wash solution was greater than 10. Finally, the reaction mixture was filtered to afford the target products 2-methyl-4-chloroquinoline (6a-c).

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 138, p. 1114 - 1125
[2] Patent: US2008/171765, 2008, A1. Location in patent: Page/Page column 19-20
[3] Australian Journal of Chemistry, 2003, vol. 56, # 1, p. 39 - 44
[4] Letters in Drug Design and Discovery, 2018, vol. 15, # 9, p. 937 - 944
[5] Patent: WO2018/178277, 2018, A1. Location in patent: Paragraph 00114

4-CHLORO-2-METHYLQUINOLINE Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Diphenyl ether Phosphorus oxitrichloride Methyl acetoacetate Ethyl crotonate 4-Hydroxy-2-methylquinoline Phosphorus pentachloride Aniline Hydrochloric acid Dichloromethane Phosphorus pentoxide PETROLEUM ETHER

Preparation Products

4-AMINO-2-METHYLQUINOLINE

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4295-06-1, 4-CHLORO-2-METHYLQUINOLINERelated Search:

6-(BROMOMETHYL)-4-CHLORO-2-(TRIFLUOROMETHYL)-QUINOLINE 2-METHYL-4,6,8-TRICHLOROQUINOLINE 4-CHLORO-6-METHYL-2-(TRIFLUOROMETHYL)QUINOLINE 6-Methoxy-4-chloro-2-methylquinoline 4-CHLOROQUINALDINE HCL 4-CHLORO-2-METHYLQUINOLINE 2-METHYL-4,7,8-TRICHLOROQUINOLINE 6-BROMO-4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE 2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE 4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE 4-CHLORO-2-PHENYLQUINOLINE, 99 8-CHLORO-5-METHYLQUINOLINE 5-Chloroquinaldine 2-Chloro-4-methylquinoline, 2-Chlorolepidine 2-CHLORO-6-METHYLQUINOLINE CARBOXALDEHYDE ethyl 4-chloro-2-methylquinoline-6-carboxylate 6,7-DICHLOROQUINALDINE 7-CHLORO-3-METHYLQUINOLINE-8-CARBOXYLICACID

JR-8354, 4-Chloroquinaldine, 97%

TIMTEC-BB SBB005362

AKOS BBS-00000956

4-CHLOROQUINALDINE

4-CHLORO-2-METHYLQUINOLINE

Quinaldine, 4-chloro-

Quinoline, 4-chloro-2-methyl-

2-Methyl-4-chloroquinoline

4-Chloroquinaldine 99%

4-Chloro-2-methylquinoline&gt

4-CHLORO-2-METHYLQUINOLINE ISO 9001：2015 REACH

4295-06-1

Building Blocks

Quinaldines

Halogenated Heterocycles

Heterocyclic Building Blocks

Quinolines, Isoquinolines & Quinoxalines

QuinaldinesHeterocyclic Building Blocks

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Quinaldines

Quinolines

Halides

Quinolines, Isoquinolines & Quinoxalines