ChemicalBook > CAS DataBase List > Desoxycorticosterone

Desoxycorticosterone

Product Name
Desoxycorticosterone
CAS No.
64-85-7
Chemical Name
Desoxycorticosterone
Synonyms
DOC;CORTEXONE;Corthormon;Deoxycortone;Desoxycorton;DOC【steroid】;DESOXYCORTONE;'REICHSTEIN Q';DEOXYCORTICOSTERONE;DESOXYCORTICOSTERONE
CBNumber
CB4314147
Molecular Formula
C21H30O3
Formula Weight
330.46
MOL File
64-85-7.mol
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Desoxycorticosterone Property

Melting point:
138-144 °C
alpha 
184 º (c=1, C2H5OH)
Boiling point:
407.89°C (rough estimate)
Density 
1.0998 (rough estimate)
refractive index 
1.5192 (estimate)
Flash point:
9℃
storage temp. 
-20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
12.98±0.10(Predicted)
form 
Solid
color 
White to Pale Yellow
optical activity
+17822 (c 1.5, ethanol)
Water Solubility 
slightly soluble
Merck 
13,2917
BRN 
2062123
LogP
2.880
CAS DataBase Reference
64-85-7(CAS DataBase Reference)
NIST Chemistry Reference
Deoxycorticosterone(64-85-7)
EPA Substance Registry System
Deoxycorticosterone (64-85-7)
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Safety

Hazard Codes 
Xn,T,F
Risk Statements 
40-48-39/23/24/25-23/24/25-11
Safety Statements 
22-24/25-45-36/37-16-7
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
HG0350000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H351Suspected of causing cancer

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D6875
Product name
21-Hydroxyprogesterone
Purity
≥97% (HPLC)
Packaging
1g
Price
$386
Updated
2024/03/01
Sigma-Aldrich
Product number
D-105
Product name
11-Deoxycorticosterone solution
Purity
100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$128
Updated
2024/03/01
Cayman Chemical
Product number
22916
Product name
11-deoxy Corticosterone
Purity
≥95%
Packaging
25mg
Price
$55
Updated
2024/03/01
Cayman Chemical
Product number
22916
Product name
11-deoxy Corticosterone
Purity
≥95%
Packaging
50mg
Price
$101
Updated
2024/03/01
Sigma-Aldrich
Product number
D6875
Product name
21-Hydroxyprogesterone
Purity
≥97% (HPLC)
Packaging
500mg
Price
$221
Updated
2024/03/01
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Desoxycorticosterone Chemical Properties,Usage,Production

Chemical Properties

white to creamy-white crystalline powder

Uses

A mineralocorticoid that occurs in adrenal cortex. It acts as a precursor to Aldosterone (A514700).

Uses

Antiinflammatory;Corticoide

Definition

ChEBI: A mineralocorticoid that is progesterone substituted at position 21 by a hydroxy group.

General Description

11-Deoxycorticosterone is a steroid hormone produced in the adrenal glands that acts as a precursor for the hormone aldosterone. Levels of 11-deoxycorticosterone are measured by LC-MS/MS to aid in diagnosing disorders of steroid synthesis, such as 11-hydroxylase deficiency and glucocorticoid responsive hyperaldosteronism. This Certified Spiking Solution? is suitable for use as starting material inlinearity standards, calibrators, and controls for numerous LC-MS/MS applications in endocrinology, clinical chemistry, and neonatal screening.

Hazard

Toxic.

Mechanism of action

Desoxycorticosterone causes an increase in reabsorption of sodium ions and excretion of potassium ions from the renal tubules, which leads to increased tissue hydrophilicity. This facilitates an elevated volume of plasma and increased arterial pressure. Muscle tonicity and work capability are increased. It is used for an insufficiency of function of the adrenal cortex, myasthenia, asthenia, adynamia, and overall muscle weakness.

Synthesis

Desoxycorticosterone, 21-hydroxypregn-4-en-3,20-dione acetate (27.2.6), is synthesized in a number of ways, the easiest of which being iodination of progesterone at C21 in the methyl group, and subsequent reaction of the resulting iodo-derivative 27.2.5 with potassium acetate, which leads to formation of the desired desoxycorticosterone in the form of the acetate (27.2.6) .

Purification Methods

Crystallise 11-deoxycorticosterone from diethyl ether. [Schindler et al. Helv Chim Acta 24 360 1941, Steiger & Reichstein Helv Chim Acta 20 1164 1937.]

Desoxycorticosterone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Desoxycorticosterone manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Desoxycorticosterone 64-85-7
Price
US $0.00-0.00/mg
Min. Order
1mg
Purity
98%
Supply Ability
10g/month
Release date
2023-02-17

64-85-7, DesoxycorticosteroneRelated Search:

Chenodeoxycholic acid CORTICOSTERONE Ursodeoxycholic acid Doxifluridine D-METHAMPHETAMINE REICHSTEIN'S SUBSTANCE S 21-ACETATE 4-PREGNEN-6-BETA, 17,21-TRIOL-3,11,20-TRIONE Hydrocortisone Hydrocortisone acetate Cortisone acetate Flurandrenolide CORTISONE 11-DEHYDROCORTICOSTERONE Hydrocortisone 21-hemisuccinate (-)-2-[METHYLAMINO]-1-PHENYLPROPANE Hydrocortisone sodium succinate desoxycorticosterone-21-acetat DESOXYCORTICOSTERONE PROPIONATE

  • Corthormon
  • Corticosterone, 11-deoxy-
  • Deoxycortone
  • Pregn-4-en-21-ol-3,20-dione
  • Pregn-4-ene-3,20-dione, 21-hydroxy-
  • Progesterone, 21-hydroxy-
  • deoxycorticosterone crystalline
  • Desoxycorton
  • 21-HYDROXYPROGESTERON VETRANAL, 250 MG
  • 17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
  • HYDROXYPROGESTERONE, 21-(RG)
  • Reichstein Q, 11-Deoxycorticosterone, 11-Desoxycorticosterone, 21-Hydroxy-4-pregnene-3,20-dione, 4-Pregnen-21-ol-3,20-dione, Cortexone, Desoxycortone, DOC, Kendalls desoxy compound B
  • Deoxycorticosterone Propionate
  • DOC【steroid】
  • DesoxycorticosteroneDeoxycorticosterone
  • 21-Hydroxy-3,20-dioxopregn -4-ene
  • 21-Hydroxy-4-pregnane-3,20-dione
  • CORTEXONE
  • DELTA4-PREGNEN-21-OL-3,20-DIONE
  • DEOXYCORTICOSTERONE
  • DESOXYCORTICOSTERONE
  • DESOXYCORTONE
  • DOC
  • HYDROXYPROGESTERONE, 21-
  • KENDALL'S DESOXY COMPOUND B
  • 4-PREGNENE-21-OL-3,20-DIONE
  • 4-PREGNEN-21-OL-3,20-DIONE
  • 11-DESOXYCORTICOSTERONE
  • 11-DEOXYCORTICOSTERONE
  • 21-HYDROXY-4-PREGNENE-3,20-DIONE
  • 21-hydroxypregn-4-ene-3,20-dione
  • 21-HYDROXYPROGESTERONE
  • 'REICHSTEIN Q'
  • REICHSTEIN'S COMPOUND ''Q''
  • REICHSTEIN'S SUBSTANCE Q
  • (8S,10R,13S,17S)-17-(2-Hydroxy-acetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
  • 11-Dehydroxycorticosterone
  • 21-Hydroxypregn-4-en-3,20-dione
  • 21-hydroxy-progesteron
  • Desoxycorticosterone Solution, 100ppm
  • 11-Deoxycorticosterone solution
  • Corticosterone Impurity 5
  • 11-Deoxycorticosterone-2,3,4-13C3 solution 100 mug/mL in methanol, >=99 atom % 13C, >=98% (CP)
  • Desoxycorticosterone USP/EP/BP
  • 21-hydroxyprogesteroneQ: What is 21-hydroxyprogesterone Q: What is the CAS Number of 21-hydroxyprogesterone Q: What is the storage condition of 21-hydroxyprogesterone
  • 2H6]-Deoxycorticosterone
  • 2H4]-11-Deoxycorticosterone
  • 64-85-7
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