Desoxycorticosterone Property

Melting point:

138-144 °C

alpha 

184 º (c=1, C2H5OH)

Boiling point:

407.89°C (rough estimate)

Density 

1.0998 (rough estimate)

refractive index 

1.5192 (estimate)

Flash point:

9℃

storage temp. 

-20°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

12.98±0.10(Predicted)

form 

Solid

color 

White to Pale Yellow

optical activity

+17822 (c 1.5, ethanol)

Water Solubility 

slightly soluble

Merck 

13,2917

BRN 

2062123

LogP

2.880

CAS DataBase Reference

64-85-7(CAS DataBase Reference)

NIST Chemistry Reference

Deoxycorticosterone(64-85-7)

EPA Substance Registry System

Deoxycorticosterone (64-85-7)

Safety

Hazard Codes 

Xn,T,F

Risk Statements 

40-48-39/23/24/25-23/24/25-11

Safety Statements 

22-24/25-45-36/37-16-7

RIDADR 

UN 2811 6.1/PG 2

WGK Germany 

3

RTECS 

HG0350000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H351Suspected of causing cancer

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

Desoxycorticosterone Chemical Properties,Usage,Production

Chemical Properties

white to creamy-white crystalline powder

Uses

A mineralocorticoid that occurs in adrenal cortex. It acts as a precursor to Aldosterone (A514700).

Uses

Antiinflammatory;Corticoide

Definition

ChEBI: A mineralocorticoid that is progesterone substituted at position 21 by a hydroxy group.

General Description

11-Deoxycorticosterone is a steroid hormone produced in the adrenal glands that acts as a precursor for the hormone aldosterone. Levels of 11-deoxycorticosterone are measured by LC-MS/MS to aid in diagnosing disorders of steroid synthesis, such as 11-hydroxylase deficiency and glucocorticoid responsive hyperaldosteronism. This Certified Spiking Solution^? is suitable for use as starting material inlinearity standards, calibrators, and controls for numerous LC-MS/MS applications in endocrinology, clinical chemistry, and neonatal screening.

Hazard

Toxic.

Mechanism of action

Desoxycorticosterone causes an increase in reabsorption of sodium ions and excretion of potassium ions from the renal tubules, which leads to increased tissue hydrophilicity. This facilitates an elevated volume of plasma and increased arterial pressure. Muscle tonicity and work capability are increased. It is used for an insufficiency of function of the adrenal cortex, myasthenia, asthenia, adynamia, and overall muscle weakness.

Synthesis

Desoxycorticosterone, 21-hydroxypregn-4-en-3,20-dione acetate (27.2.6), is synthesized in a number of ways, the easiest of which being iodination of progesterone at C21 in the methyl group, and subsequent reaction of the resulting iodo-derivative 27.2.5 with potassium acetate, which leads to formation of the desired desoxycorticosterone in the form of the acetate (27.2.6) .

Purification Methods

Crystallise 11-deoxycorticosterone from diethyl ether. [Schindler et al. Helv Chim Acta 24 360 1941, Steiger & Reichstein Helv Chim Acta 20 1164 1937.]